Desogestrel
- CAS No.
- 54024-22-5
- Chemical Name:
- Desogestrel
- Synonyms
- Desogestrel for system suitability CRS;Desogen;Desogestrel CRS;org2969;Cyclosa;Dicromil;DESTODENE;Cerazette;DESOGESTREL;DESOGESTRAL
- CBNumber:
- CB2359630
- Molecular Formula:
- C22H30O
- Molecular Weight:
- 310.47
- MOL File:
- 54024-22-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/3/13 16:52:01
| Melting point | 109-110°C |
|---|---|
| alpha | D20 +55° (chloroform) |
| Boiling point | 390.62°C (rough estimate) |
| Density | 1.0169 (rough estimate) |
| refractive index | 1.5100 (estimate) |
| storage temp. | -20°C Freezer |
| solubility | Practically insoluble in water, very soluble in methanol, freely soluble in anhydrous ethanol and in methylene chloride. |
| pka | 13.07±0.40(Predicted) |
| color | White to Almost white |
| Merck | 14,2926 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H360FD-H410 |
| Precautionary statements | P202-P273-P280-P308+P313-P391-P405 |
| Safety Statements | 24/25 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| RTECS | JF7975000 |
| HS Code | 29372390 |
Desogestrel price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR1830 | Desogestrel Pharmaceutical Secondary Standard; Certified Reference Material | 54024-22-5 | 100MG | ₹18954.58 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 32809 | Desogestrel VETRANAL?, analytical standard | 54024-22-5 | 25MG | ₹15717.9 | 2022-06-14 | Buy |
| TCI Chemicals (India) | D4163 | Desogestrel | 54024-22-5 | 100MG | ₹10900 | 2022-05-26 | Buy |
Desogestrel Chemical Properties,Uses,Production
Description
Desogestrel is a synthetic progestogen. It inhibits ovulation and prevents fertilization in rabbits and mice. Desogestrel inhibits rhodamine 123 efflux, a measure of P-glycoprotein activity, ex vivo in human lymphocytes and CD8+ T cells in a dose-dependent manner. Formulations containing desogestrel have been used as oral contraceptives and for the treatment of polycystic ovary syndrome.
Chemical Properties
White Solid
Uses
A progestogen with low androgenic potency
General Description
Desogestrel, (17α)-13-ethyl-11-methylene-18,19-dinorpregn-4-en-20-yn-17-ol, is a 19-nortestosterone analog with good progestin activity. Likethe other progestins, it is orally active and used in combinationwith an estrogen in oral contraceptives. Desogestrel is aprodrug that must be oxidized to the 3-one in vivo to haveprogestational action. CYPs 2C9 and 2C19 have been implicatedin the initial hydroxylation of desogestrel at C3.
Clinical Use
Desogestrel also is a prodrug and is rapidly metabolized in the intestinal mucosa and on first pass through the liver to its active metabolite, etonogestrel (3-ketodesogestrel). Following oral administration, the relative bioavailability for desogestrel is approximately 84%. Desogestrel also exhibits high selectivity for the progesterone receptor and low and rogenic activity, and it does not diminish the beneficial effects of estrogen on the lipid profile.
Desogestrel Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Gonane Pharma | +91-9819380043 +91-9819380043 | NaviMumbai, India | 192 | 58 | Inquiry |
| PANCHSHEEL ORGANICS LTD | +91-9821053955 +91-9324201019 | Mumbai, India | 82 | 58 | Inquiry |
| Swati Spentose Pvt Ltd | +91-2261505232 +91-2261505232 | Maharashtra, India | 44 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| AKASH PHARMA EXPORTS | +91-9388123451 +91-9846039283 | Kerela, India | 470 | 58 | Inquiry |
| Symbiotec Pharma Lab Pvt Ltd | +91-7316676406 +91-7316676405 | Madhya Pradesh, India | 71 | 58 | Inquiry |
| Chemsynth Drugs & Pharmaceuticals Pvt Ltd. | 91-11-43005480 | Delhi, India | 71 | 58 | Inquiry |
| Athos Chemicals | 91-9998858909 | Gujarat, India | 315 | 58 | Inquiry |
| Ralington Pharma. | 91-79-48911722 | Gujarat, India | 311 | 58 | Inquiry |
| Lalchand Bhimraj Group | 91-44-25354424 | Tamil Nadu, India | 50 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Gonane Pharma | 58 |
| PANCHSHEEL ORGANICS LTD | 58 |
| Swati Spentose Pvt Ltd | 58 |
| Ralington Pharma | 58 |
| AKASH PHARMA EXPORTS | 58 |
| Symbiotec Pharma Lab Pvt Ltd | 58 |
| Chemsynth Drugs & Pharmaceuticals Pvt Ltd. | 58 |
| Athos Chemicals | 58 |
| Ralington Pharma. | 58 |
| Lalchand Bhimraj Group | 58 |
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