Phenethyl caffeate
- CAS No.
- 104594-70-9
- Chemical Name:
- Phenethyl caffeate
- Synonyms
- CAFFEIC ACID PHENETHYL ESTER;CAFFEIC ACID PHENYLETHYL ESTER;PHENETHYL CAFFEATE;Phenylethy caffeate;PHENYLETHYL CAFFEATE;PhenethylCaffeate>Caffeic acid pheneth;2-Phenyethyl caffeate;CAPE,PhenethylCaffeate;Caffeic acid phenethyl
- CBNumber:
- CB2438898
- Molecular Formula:
- C17H16O4
- Molecular Weight:
- 284.31
- MOL File:
- 104594-70-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/11/17 16:00:36
| Melting point | 127-129℃ |
|---|---|
| Boiling point | 498.6±45.0 °C(Predicted) |
| Density | 1.266±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in ethyl acetate at 50mg/ml. Soluble in DMSO and ethanol. |
| pka | 8.46±0.20(Predicted) |
| form | White to off-white solid |
| color | off-white |
| λmax | 323nm(lit.) |
| Sensitive | Light Sensitive |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| InChIKey | SWUARLUWKZWEBQ-VQHVLOKHSA-N |
| LogP | 3.734 (est) |
| CAS DataBase Reference | 104594-70-9(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38-38-37-36 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UD3334375 | |||||||||
| HS Code | 29182900 | |||||||||
| NFPA 704 |
|
Phenethyl caffeate price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C8221 | Caffeic acid phenethyl ester ≥97% (HPLC), powder | 104594-70-9 | 1G | ₹63759.25 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 211200 | CAPE - CAS 104594-70-9 - Calbiochem A cell-permeable active component of propolis from honeybee hives. | 104594-70-9 | 25MG | ₹13100 | 2022-06-14 | Buy |
| TCI Chemicals (India) | P2088 | Phenethyl Caffeate | 104594-70-9 | 25MG | ₹2000 | 2022-05-26 | Buy |
| ALFA India | ALF-J61386-MD | Phenylethyl 3,4-dihydroxycinnamate, 98+% | 104594-70-9 | 250mg | ₹7018 | 2022-05-26 | Buy |
| TCI Chemicals (India) | P2088 | Phenethyl Caffeate | 104594-70-9 | 250MG | ₹9600 | 2022-05-26 | Buy |
Phenethyl caffeate Chemical Properties,Uses,Production
Description
Phenylethyl caffeate is one of the allergens of propolis (bee glue); also contained in poplar-bud secretions.
Chemical Properties
Off-White Solid
Uses
Cytotoxic agent against cancer cell lines. Inhibitor of ornithine decarboxylase and protein tyrosine kinase. Found to be a specific inhibitor of the nuclear transcription factor, NF-kB. It has also been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation.
Biological Activity
Antioxidant, antimitogenic, anticarcinogenic, anti-inflammatory and antiviral. Specifically inhibits NF- κ B activation and inhibits the growth of transformed cells. Also suppresses lipid peroxidation and inhibits ornithine decarboxylase, protein tyrosine kinase and lipoxygenase activities.
Contact allergens
Capee is one of the allergens of propolis (bee glue). It is also contained in poplar bud secretions.
Anticancer Research
Caffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester (CAPE) is a natural phenolcompound and an active component of propolis from honeybee hives. Torkiet al. (2017)investigated the effect of phosphatidylinositol 3-kinase/AKT/mammaliantarget of rapamycin (PI3K/Akt/mTOR) signaling pathway dual inhibitor, NVP-BEZ235,and CAPE on TNBC cell line (MDA-MB-231), stimulated withtransforming growth factor (TGF)-β1 for 14 days. CAPE in combination with NVP-BEZ235synergistically inhibited cell growth and reduced CXCR4 expression.Also, treatment of MDA-MB-231 cells with CAPE and NVP-BEZ235 time-dependentlyinhibited the expression of p-Forkhead Box O3a (FOXO3a). In a nutshell,these results indicate that tumour metastasis and progression in TNBC cellscan be effectively reduced through the concurrent use of NVP-BEZ235 and CAPE(Torki et al. 2017).
Phenethyl caffeate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6100 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6768 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6905 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6739 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6754 | 58 | Inquiry |
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | China | 8813 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12840 | 58 | Inquiry |
| Hubei Langyou International Trading Co., Ltd | +86-18874586545 +86-18874586545 | China | 196 | 58 | Inquiry |
| Wuhan senwayer century chemical Co.,Ltd | +undefined-27-86652399 +undefined13627115097 | China | 902 | 58 | Inquiry |