Ibutilide fumarate
- CAS No.
- 122647-32-9
- Chemical Name:
- Ibutilide fumarate
- Synonyms
- D00648;Corvert (tn);Corvert Fumarate;Ibutilide fumarate;IBUTILIDE FUMRTATE;Ibutibide Fumarate;Ibulitide fumarate;Ibutilide 1/2Fumarate;Ibutilide hemifumarate;IbutilideHemifumarate>
- CBNumber:
- CB2511478
- Molecular Formula:
- (C20H36N2O3S)2.C4H4O4
- Molecular Weight:
- 885.24
- MOL File:
- 122647-32-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/1/27 9:38:02
| Melting point | 112-117?C |
|---|---|
| RTECS | PB0475700 |
| storage temp. | 2-8°C |
| solubility | H2O: >20mg/mL |
| form | solid |
| color | off-white to tan |
| Water Solubility | H2O: >20mg/mL |
| λmax | 267nm(EtOH)(lit.) |
| Merck | 14,4883 |
| CAS DataBase Reference | 122647-32-9(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H361d | |||||||||
| Precautionary statements | P202-P264-P270-P280-P301+P312-P308+P313 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 1 | |||||||||
| HS Code | 2935904000 | |||||||||
| Toxicity | rat,LD,oral,> 500mg/kg (500mg/kg),Teratology, The International Journal of Abnormal Development. Vol. 49, Pg. 406, 1994. | |||||||||
| NFPA 704 |
|
Ibutilide fumarate price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | I9910 | Ibutilide hemifumarate salt ≥98% (HPLC) | 122647-32-9 | 10MG | ₹14115.8 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | I9910 | Ibutilide hemifumarate salt ≥98% (HPLC) | 122647-32-9 | 50MG | ₹53616.23 | 2022-06-14 | Buy |
| TCI Chemicals (India) | I0946 | Ibutilide Hemifumarate | 122647-32-9 | 100MG | ₹10200 | 2022-05-26 | Buy |
Ibutilide fumarate Chemical Properties,Uses,Production
Description
Covert was launched in the US and UK for treatment of atrial fibrillation and flutter and can be synthesized in three steps from N-phenyl rnethanesulfonamide. While ibutilide has an asymmetric center, it has been determined that the racemate is equipotent with either enantiomer. The antiarrhythmic action is derived from the compounds ability to prolong the action potential duration and lengthen the refractory period of myocardial tissue. Class Ⅲ antiarrhythrnic agents accomplish this by blocking outward potassium channels, however, ibutilide elicits the same effect by activation of slow inward sodium channels. Recent evidence indicates that it also is a potent blocker of the rapidly acting delayed rectifier potassium current (lkr)and may block the ATP-inhibited potassium channel.
Chemical Properties
White to Off-White Solid
Uses
A methanesulfonanilide antiarrhythmic agent; prologns myocardial action potential duration, predominantly by activation of slow inward sodium current. Antiarrhythmic (class III).
Clinical Use
Ibutilide (Corvert) is a structural analog of sotalol and
produces cardiac electrophysiological effects similar to
those of the antiarrhythmic agents in class III.
Ibutilide is approved for the chemical cardioversion of
recent-onset atrial fibrillation and atrial flutter. Ibutilide
appears to be more effective in terminating atrial flutter
than atrial fibrillation. It can also lower the defibrillation threshold for atrial fibrillation resistant to chemical
cardioversion.
Side effects
The major adverse effect associated with the use of ibutilide is the risk of torsades de pointes due to QT prolongation. Other reported adverse cardiovascular events (all 2%) include hypotension and hypertension, bradycardia and tachycardia, and varying degrees of A-V block. The incidence of noncardiac adverse events with the exception of nausea does not differ from that of placebo.
Drug interactions
Ibutilide has significant drug interactions.
Precautions
Contraindications to the use of ibutilide include baseline prolongation of the QT interval, use of other QTprolonging drugs, history of torsades de pointes, hypersensitivity to ibutilide, uncorrected hypokalemia or hypomagnesemia, and pregnancy or breast-feeding.
Ibutilide fumarate Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4535 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3887 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6100 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6768 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6514 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6739 | 58 | Inquiry |
| Jigs Chemical Limited | +91 80 4290 2764 | Ahmedabad, India | 235 | 58 | Inquiry |
| Sai Life Sciences Ltd. | 08048372046Ext 374 | Hyderabad, India | 9 | 58 | Inquiry |
| Cip Global (India) | +91 22 2875 5200 | Mumbai, India | 81 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| GLR Innovations | 58 |
| Clearsynth Labs | 58 |
| A.J Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| SynZeal Research Pvt Ltd | 58 |
| Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |
| Jigs Chemical Limited | 58 |
| Sai Life Sciences Ltd. | 58 |
| Cip Global (India) | 58 |
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