Granisetron
- CAS No.
- 109889-09-0
- Chemical Name:
- Granisetron
- Synonyms
- BRL 43964;BRL 43694;GRANISETRON;GRANESETRON;Granisteron;Gramisetron;Granisetron USP/EP/BP;granisetron(base,HCl);GRANISETRON(FREE BASE);Granisetron Impurity 22
- CBNumber:
- CB2728852
- Molecular Formula:
- C18H24N4O
- Molecular Weight:
- 312.41
- MOL File:
- 109889-09-0.mol
- Modify Date:
- 2024/7/2 8:55:04
| Boiling point | 532.0±40.0 °C(Predicted) |
|---|---|
| Density | 1.33±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | 25℃: DMSO |
| form | Powder |
| pka | 12.34±0.20(Predicted) |
| color | White to off-white |
| InChI | InChI=1/C18H24N4O/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23)/t12-,13+,14-/i2D3 |
| InChIKey | MFWNKCLOYSRHCJ-JQHPXDLNNA-N |
| SMILES | C1(C(=O)N[C@H]2C[C@@]3([H])CCC[C@@]([H])(C2)N3C)C2C=CC=CC=2N(C([2H])([2H])[2H])N=1 |&1:4,6,11,r| |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H412-H302-H319 |
| Precautionary statements | P273-P501-P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P |
| HS Code | 2933399090 |
Granisetron Chemical Properties,Uses,Production
Uses
Granisetron is a selective 5HT-3 antagonist.
Indications
granisetron (Kytril) is potent antagonists of 5-HT3 receptors,which is found peripherally on vagal nerve terminals and centrally in the CTZ. During chemotherapy that induces vomiting, mucosal enterochromaffin cells in the GI tract release serotonin, which stimulates 5-HT3 receptors.
Definition
ChEBI: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 1-methyl-1H-indazole-3-carboxylic acid with the primary amino group of (3-endo)-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine. A sele tive 5-HT3 receptor antagonist, it is used (generally as the monohydrochloride salt) to manage nausea and vomiting caused by cancer chemotherapy and radiotherapy, and to prevent and treat postoperative nausea and vomiting.
Side effects
This causes vagal afferent discharge, inducing vomiting. In binding to 5-HT3 receptors, granisetron blocks serotonin stimulation, hence vomiting, after emetogenic stimuli such as cisplatin. Headache is the most frequently reported adverse effect of these medications.
Granisetron Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Jigs Chemical ltd | +919099003427 | Gujarat, India | 239 | 58 | Inquiry |
| Dr. Reddy's Laboratories Ltd | +91-4049002900 +91-4049002900 | Hyderabad, India | 165 | 58 | Inquiry |
| Mehta Pharmaceutical Industries | +91-8390068777 +91-8390068777 | Mumbai, India | 30 | 58 | Inquiry |
| SNECOFRi Pvt Ltd | +91-9032850129 +91-9032850129 | Telangana, India | 404 | 58 | Inquiry |
| Dayaram Pharma Chem | +91-9601766800 +91-9601766800 | Gujarat, India | 61 | 58 | Inquiry |
| Swati Spentose Pvt Ltd | +91-2261505232 +91-2261505232 | Maharashtra, India | 44 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Globela Industry Pvt Ltd | +91-2616158000 +91-9998199919 | Gujarat, India | 98 | 58 | Inquiry |
| Cipla Ltd | +912224826000 | Maharashtra, India | 133 | 58 | Inquiry |
| Niksan Pharmaceutical | +91-9537871777 +91-9537871777 | Gujarat, India | 39 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Jigs Chemical ltd | 58 |
| Dr. Reddy's Laboratories Ltd | 58 |
| Mehta Pharmaceutical Industries | 58 |
| SNECOFRi Pvt Ltd | 58 |
| Dayaram Pharma Chem | 58 |
| Swati Spentose Pvt Ltd | 58 |
| Ralington Pharma | 58 |
| Globela Industry Pvt Ltd | 58 |
| Cipla Ltd | 58 |
| Niksan Pharmaceutical | 58 |
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