Vamidothion
- CAS No.
- 2275-23-2
- Chemical Name:
- Vamidothion
- Synonyms
- nph83;nph-83;KILVAL;10465rp;rp-9895;trucidor;ent26,613;vamidoate;Kilval[R];r.p.10,465
- CBNumber:
- CB2771555
- Molecular Formula:
- C8H18NO4PS2
- Molecular Weight:
- 287.34
- MOL File:
- 2275-23-2.mol
- Modify Date:
- 2023/4/23 13:52:06
| Melting point | 35.5°C |
|---|---|
| Boiling point | 72.8°C |
| Density | 1.240±0.06 g/cm3(Predicted) |
| vapor pressure | 9×10-6 Pa (est.) |
| Flash point | 2 °C |
| storage temp. | 0-6°C |
| Water Solubility | 4,000,000 mg l-1 |
| pka | 15.22±0.46(Predicted) |
| CAS DataBase Reference | 2275-23-2(CAS DataBase Reference) |
| NIST Chemistry Reference | Phosphorothioic acid, o,o-dimethyl s-[2-[[1-methyl-2-(methylamino)-2-oxoethyl]thio]ethyl] ester(2275-23-2) |
| EPA Substance Registry System | Vamidothion (2275-23-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H225-H302+H312+H332-H319 |
| Precautionary statements | P210-P280-P305+P351+P338 |
| Hazard Codes | T;N,N,T,Xn,F |
| Risk Statements | 21-25-50-36-20/21/22-11 |
| Safety Statements | 36/37-45-61-16 |
| RIDADR | UN 2811 |
| WGK Germany | 2 |
| RTECS | TF7900000 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Toxicity | LD50 oral in rabbit: 160mg/kg |
Vamidothion Chemical Properties,Uses,Production
Description
Vamidothion is a colorless crystalline substance,. It is readily soluble in water (4 kg/L) and most organic solvents except aliphatic hydrocarbons. Log Kow = 0.12. It decomposes in strong alkaline and acidic media.
Uses
Vamidothion is a phosphorothioic insecticide for apples and potatoes.
Definition
ChEBI: An organic thiophosphate that is N-methyl-2-[(2-sulfanylethyl)sulfanyl]propanamide in which the thiol group has been converted to the corresponding O,O-dimethyl thiophoshate. Formerly used as an inse ticide and acaricide, it is no longer approved for use within the European Union.
Pharmacology
Pyriproxyfen formulations demonstrate persistent efficacy. For example, a water-based 5.3% pyriproxyfen spot-on formulation applied to cats was reported to completely prevent the hatching of flea eggs for at least 46 days after treatment and continued to provide greater than 96% control until day 60 (57). Because pyriproxyfen is efficacious at very low concentrations, trace amounts of the chemical, when transferred from treated pets to their environments, are sufficient to inhibit the development of larvae.
Metabolic pathway
Vamidothion is mainly metabolised via oxidation to its sulfoxide; further oxidation to the corresponding sulfone has been observed in houseflies but occurs much less readily than with other thioether-containing organophosphates (e.g. phorate). The sulfoxide is then hydrolysed via P-S and C-S bond cleavage to give the thiol or hydroxyl derivatives and dimethyl phosphate and O,O-dimethyl phosphorothioate respectively. O-Demethylation apparently occurs as a major degradation process in plants but has not been observed in soil or in animals. N-Demethylation and hydrolysis to the corresponding carboxylic acid, such as occurs with dimethoate, does not apparently happen in the case of vamidothion.
Vamidothion Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | China | 10312 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | China | 52861 | 58 | Inquiry |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | China | 9003 | 58 | Inquiry |
| Hebei Guanlang Biotechnology Co., Ltd. | +8619930503259 | China | 18433 | 58 | Inquiry |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | China | 12272 | 58 | Inquiry |