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L-161,982

L-161,982 Structure
CAS No.
147776-06-5
Chemical Name:
L-161,982
Synonyms
L-161,982;L-161,982 >=98% (HPLC);colon,cancer,phosphorylation,prostaglandin,Prostaglandin Receptor,L161982,arthritis,inhibit,proliferation,L 161982,L-161982,Inhibitor;N-[2-[4-[[3-butyl-5-oxo-1-[2-(trifluoromethyl)phenyl]-1,2,4-triazol-4-yl]methyl]phenyl]phenyl]sulfonyl-3-methylthiophene-2-carboxamide;N-[[4'-[[3-Butyl-1,5-dihydro-5-oxo-1-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-4-yl]methyl][1,1'-biphenyl]- 2-yl]sulfonyl]-3-methyl-2-thiophenecarboxamide;2-Thiophenecarboxamide, N-[[4'-[[3-butyl-1,5-dihydro-5-oxo-1-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-4-yl]methyl][1,1'-biphenyl]-2-yl]sulfonyl]-3-methyl-
CBNumber:
CB31074878
Molecular Formula:
C32H29F3N4O4S2
Molecular Weight:
654.72
MOL File:
147776-06-5.mol
MSDS File:
SDS
Modify Date:
2023/9/4 15:50:00
Request For Quotation

L-161,982 Properties

Density 1.37±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: soluble15mg/mL, clear
pka 4.57±0.10(Predicted)
form powder
color white to beige

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338
WGK Germany  3

L-161,982 price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SML0690 L-161,982 ≥98% (HPLC) 147776-06-5 5MG ₹15869.45 2022-06-14 Buy
Sigma-Aldrich(India) SML0690 L-161,982 ≥98% (HPLC) 147776-06-5 25MG ₹63824.2 2022-06-14 Buy
Product number Packaging Price Buy
SML0690 5MG ₹15869.45 Buy
SML0690 25MG ₹63824.2 Buy

L-161,982 Chemical Properties,Uses,Production

Description

Prostaglandin E2 (PGE2) exerts its effects through four separate G coupled-protein receptors (EP1-4). L-161,982 is a potent and selective EP4 receptor antagonist. It demonstrates selective binding to human EP4 receptors with a Ki value of 0.024 μM compared to other receptors of the prostanoid family, EP1, EP2, EP3, DP, FP, and IP, with Ki values of 17, 23, 1.9, 5.1, 5.6, and 6.7 μM, respectively. L-161,982 at 10 mg/kg/day suppresses PGE2-stimulated bone formation in young rats and at 100 nM reverses the anti-inflammatory action of PGE2 in LPS-activated human macrophages. At 10 μM L-161982 blocks PGE2-induced cell proliferation in HCA-7 colon cancer cells.

Uses

L-161,982 is an EP4 receptor antagonist, which blocks prostaglandin E2-induced signal transduction and cell proliferation in HCA-7 colon cancer cells.

Biological Activity

EP 4 receptor antagonist that is selective over all other members of the prostanoid receptor family (K i values are 0.024, 0.71, 1.90, 5.10, 5.63, 6.74, 19 and 23 μ M for human EP 4 , TP, EP 3 , DP, FP, IP, EP 1 and EP 2 receptors respectively). Suppresses PGE 2 -induced bone formation in rats and prevents the nociceptive response induced by misoprostol in formalin-injected mice.

L-161,982 Preparation Products And Raw materials

Raw materials

Preparation Products

L-161,982 Suppliers

Global( 52)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Jilin Chinese Academy of Sciences-yanshen Technology +undefined18143011203 China 42057 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 52927 58 Inquiry
Jilin Chinese Academy of Sciences-yanshen Technology 18143011203 China 40857 58 Inquiry
DC Chemicals 021-58447131 13564518121 China 9412 58 Inquiry
Cayman Chemical Company (800) 364-9897 United States 6618 81 Inquiry
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 China 9708 58 Inquiry
Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969 China 4428 55 Inquiry
BOC Sciences USA 0 65 Inquiry
Service Chemical Inc. 888-895-6920 Germany 6373 71 Inquiry
Supplier Advantage
TargetMol Chemicals Inc. 58
Jilin Chinese Academy of Sciences-yanshen Technology 58
Aladdin Scientific 58
Jilin Chinese Academy of Sciences-yanshen Technology 58
DC Chemicals 58
Cayman Chemical Company 81
Shanghai EFE Biological Technology Co., Ltd. 58
Guangzhou Isun Pharmaceutical Co., Ltd 55
BOC Sciences 65
Service Chemical Inc. 71

L-161,982 Spectrum

L-161,982(147776-06-5)1HNMR

147776-06-5(L-161,982)Related Search:

CJ-21058 GW 627368X CJ-42794 Grapiprant PROSTAGLANDIN F1ALPHA
Latanoprost Misoprostol Acid ONO-AE3-208 13,14-DIHYDROPROSTAGLANDIN E1 Prostaglandin F2a
PROSTAGLANDIN D2 6(R)-(4-CARBOXYPHENYLTHIO)-5(S)-HYDROXY-7(E),9(E),11(Z),14(Z)-EICOSATETRAENOIC ACID 11BETA-PROSTAGL AND IN F2ALPHA LEUKOTRIENE B4 DIMETHYL AMIDE LEUKOTRIENE D4
CJ 033466 L-161,982 4,5-DIETHYL-2,4-DIHYDRO 1,2,4-TRIAZOL-3 ONE
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L-161,982 N-[[4'-[[3-Butyl-1,5-dihydro-5-oxo-1-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-4-yl]methyl][1,1'-biphenyl]- 2-yl]sulfonyl]-3-methyl-2-thiophenecarboxamide N-[2-[4-[[3-butyl-5-oxo-1-[2-(trifluoromethyl)phenyl]-1,2,4-triazol-4-yl]methyl]phenyl]phenyl]sulfonyl-3-methylthiophene-2-carboxamide 2-Thiophenecarboxamide, N-[[4'-[[3-butyl-1,5-dihydro-5-oxo-1-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-4-yl]methyl][1,1'-biphenyl]-2-yl]sulfonyl]-3-methyl- L-161,982 >=98% (HPLC) colon,cancer,phosphorylation,prostaglandin,Prostaglandin Receptor,L161982,arthritis,inhibit,proliferation,L 161982,L-161982,Inhibitor 147776-06-5 C32H29F3N4O4S2 Prostanoid receptor and related