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Tianeptine

Tianeptine Structure
CAS No.
66981-73-5
Chemical Name:
Tianeptine
Synonyms
Tianeptine hemisulfate monohydrate;Tianeptineacid;Tianeptine powder;COAXIL;Tianepine;Tianeptina;Tianeotine;Brn 1232295;Tianeptinum;Thioneptine
CBNumber:
CB3217470
Molecular Formula:
C21H25ClN2O4S
Molecular Weight:
436.95
MOL File:
66981-73-5.mol
Modify Date:
2024/6/28 9:24:13
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Tianeptine Properties

Melting point 129-131°C
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility Freely soluble in water, in methanol and in methylene chloride.
form Solid
color White to Off-White
InChIKey JICJBGPOMZQUBB-UHFFFAOYSA-N
SMILES C(O)(=O)CCCCCCNC1C2=CC=C(Cl)C=C2S(=O)(=O)N(C)C2=CC=CC=C21
CAS DataBase Reference 66981-73-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

RIDADR  3249
HazardClass  6.1(b)
PackingGroup  III

Tianeptine Chemical Properties,Uses,Production

Description

Tianeptine, a tricyclic compound, is a selective facilitator of 5-HT (serotonin; sc-201146) uptake in vitro and in vivo. Additionally, Tianeptine is reported to act as a selective inhibitor of dopamine uptake and is similar to amineptine. Tianeptine does not have a noted effect on monoamine uptake.

Chemical Properties

White Solid

Uses

Tricyclic compound with psychostimulant, anti-ulcer and anti-emetic properties. Antidepressant

Uses

Tianeptine is used in the treatment of reactive and neurotic depression, as well as in the treatment of anxious states.

Biological Activity

Tianeptine was identified as an efficacious MOR full agonist, binding to the human MOR with a Ki of 383 ± 183 nM. Tianeptine was also found to act as a full agonist at the DOR, although it had much lower potency and was inactive at the KOR. The MOR was required for the acute and chronic antidepressant-like effects of tianeptine in mice. Although tianeptine also produced behavioural effects, including analgesia and reward, its effects were distinct from morphine in that it did not produce tolerance or withdrawal.

Tianeptine Preparation Products And Raw materials

Raw materials

Tianeptine sodium salt Ethyl heptanoate 7-Aminoheptanoic acid Nitromethane Sodium sulfate
Hexamethyleneimine Diethyl ether Esterified product Ethyl7-Aminoheptanoate Sodium hydroxide
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Preparation Products

Tianeptine Suppliers

Global( 324)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
VIVAN Life Sciences Pvt. Limited. +91(22) 2544 4584 / 2544 4585 New Delhi, India 138 50 Inquiry
Hebei Lingding Biotechnology Co., Ltd. +86-18031140164 +86-19933155420 China 458 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29900 58 Inquiry
Shanghai Longyu Biotechnology Co., Ltd. +8613917842738 China 2534 58 Inquiry
Hebei Miaoyin Technology Co.,Ltd +86-17367732028 +86-17367732028 China 3582 58 Inquiry
Hebei Mojin Biotechnology Co., Ltd +86 13288715578 +8613288715578 China 12460 58 Inquiry
Hebei Weimiao Import and Export Trade Co., Ltd. +undefined19948166995 China 73 58 Inquiry
Dorne Chemical Technology co. LTD +86-86-13583358881 +8618560316533 China 3148 58 Inquiry
Sigma Audley +86-18336680971 +86-18126314766 China 497 58 Inquiry
CONTIDE BIOTECH CO.,LTD +852-53358525 China 586 58 Inquiry
Supplier Advantage
VIVAN Life Sciences Pvt. Limited. 50
Hebei Lingding Biotechnology Co., Ltd. 58
career henan chemical co 58
Shanghai Longyu Biotechnology Co., Ltd. 58
Hebei Miaoyin Technology Co.,Ltd 58
Hebei Mojin Biotechnology Co., Ltd 58
Hebei Weimiao Import and Export Trade Co., Ltd. 58
Dorne Chemical Technology co. LTD 58
Sigma Audley 58
CONTIDE BIOTECH CO.,LTD 58

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7-[(3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)-amino]heptanoic acid s,s-dioxide 7-[(3-CHLORO-6,11-DIHYDRO-6-METHYL-DIBENZO[C,F][1,2]THIAZEPINE-11-YL)AMINO]HEPTANOIC ACID S,S DIOXIDE COAXIL 7-[(3-Chloro-6，11-dihydro-6-methyldibenzo[c，f][1，2]thiazepin-11-y1)amino]heptanoic acid S，S-dioxide 30123-17-2 (Mono-hydrochloride salt) Brn 1232295 Heptanoic acid, 7-((3-chloro-6,11-dihydro-6-methyldibenzo(E,F)(1,2)thiazapin-11-yl)amino)-, S,S-dioxide Tianeptina Tianeptina [inn-spanish] Tianeptinum Tianeptine-d4 Tianeotine Heptanoic acid,7-[(3-chloro-6,11-dihydro-6-Methyl-5,5-dioxidodibenzo[c,f][1,2]thiazepin-11-yl)aMino]- Tianeptine 7-[(3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)-amino]heptanoic acid S,S-dioxide 7-[(3-chloro-6-methyl-5,5-dioxo-11H-benzo[c][2,1]benzothiazepin-11-yl)amino]heptanoic acid Thiempirtine Sodium Tianeptine for system suitability CRS Raw Material Tianeptine Acid Tianeptine crystal Tianeptine(INN) Tianeptine USP/EP/BP tianeptine sodium tianeptine sulfate Tianeptine acid Tianeptineacid Tianeptine hemisulfate monohydrate Tianeptine powder Tianepine Tianeptine,Tianeptine Ethyl Ester α-Iodo-4-methylpropiophenone Thioneptine 66981-73-5 C21H25ClN2O4S Tianeptine API Tianeptine Intermediates Pharmaceuticals Heterocyclic Compounds Intermediates & Fine Chemicals Intermediate 66981-73-5