Piperonyl aldehyde
- CAS No.
- 120-57-0
- Chemical Name:
- Piperonyl aldehyde
- Synonyms
- PIPERONAL;HELIOTROPINE;HELIOTROPIN;Benzo[d][1,3]dioxole-5-carbaldehyde;Heliotroprin;3,4-(METHYLENEDIOXY)BENZALDEHYDE;Piperonaldehyde;1,3-Benzodioxole-5-carbaldehyde;3,4-(methylenedioxy)-benzaldehyd;2H-1,3-BENZODIOXOLE-5-CARBALDEHYDE
- CBNumber:
- CB3246225
- Molecular Formula:
- C8H6O3
- Molecular Weight:
- 150.13
- MOL File:
- 120-57-0.mol
- Modify Date:
- 2024/3/21 18:02:16
| Melting point | 35-39 °C(lit.) |
|---|---|
| Boiling point | 264 °C(lit.) |
| Density | 1.2645 (rough estimate) |
| vapor pressure | 1 mm Hg ( 87 °C) |
| refractive index | 1.4500 (estimate) |
| FEMA | 2911 | PIPERONAL |
| Flash point | >230 °F |
| storage temp. | Dark Room |
| solubility | methanol: 0.1 g/mL, clear |
| form | A crystalline solid |
| Odor | at 100.00 %. heliotrope flower sweet powdery coconut vanilla |
| Odor Type | floral |
| Water Solubility | Slightly soluble |
| Sensitive | Air & Light Sensitive |
| Merck | 13,7556 |
| JECFA Number | 896 |
| BRN | 131691 |
| Stability | Stable, but air and light sensitive. Combustible. Incompatible with strong oxidizing agents, bases. |
| LogP | 1.2 at 35℃ |
| CAS DataBase Reference | 120-57-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Piperonal(120-57-0) |
| EPA Substance Registry System | Piperonal (120-57-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H317 | |||||||||
| Precautionary statements | P261-P272-P280-P302+P352-P333+P313-P362+P364 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 38-52/53 | |||||||||
| Safety Statements | 61-24/25 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | TO1575000 | |||||||||
| F | 8-10-23 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29329300 | |||||||||
| Toxicity | LD50 orally in rats: 2700 mg/kg (Hagan) | |||||||||
| NFPA 704 |
|
Piperonyl aldehyde Chemical Properties,Uses,Production
Chemical Properties
white crystalline solid
Occurrence
Reported found in the essential oils of Robinia pseudo-acacia and Eryngium poterium; in the oils of Spirea ulmaria and of leaves of Doryphora sassafras; also reported found in Tahitian and Bourbon vanilla, camphor wood oil, violet flowers concrete and absolute, burley tobacco, rabbiteye blueberry, melon, pepper, cooked chicken, sherry and dill.
Uses
Piperonal is an impurity of Tadalafil (T004500). Tadalafil impurity A.
Definition
ChEBI: An arenecarbaldehyde that is 1,3-benzodioxole substituted by a formyl substituent at position 5. It has been isolated from Piper nigrum.
General Description
Colorless lustrous crystals.
Air & Water Reactions
Slightly water soluble .
Reactivity Profile
Piperonyl aldehyde is an aldehyde. Aldehydes are frequently involved in self-condensation or polymerization reactions. These reactions are exothermic; they are often catalyzed by acid. Aldehydes are readily oxidized to give carboxylic acids. Flammable and/or toxic gases are generated by the combination of aldehydes with azo, diazo compounds, dithiocarbamates, nitrides, and strong reducing agents. Aldehydes can react with air to give first peroxo acids, and ultimately carboxylic acids. These autoxidation reactions are activated by light, catalyzed by salts of transition metals, and are autocatalytic (catalyzed by the products of the reaction). The addition of stabilizers (antioxidants) to shipments of aldehydes retards autoxidation. Piperonyl aldehyde is sensitive to light. Piperonyl aldehyde may react with oxidizing materials.
Fire Hazard
Flash point data for Piperonyl aldehyde are not available. Piperonyl aldehyde is probably combustible.
Safety Profile
Moderately toxic by ingestion and intraperitoneal routes. Can cause central nervous system depression. A human skin irritant. Mutation data reported. Combustible when exposed to heat or flame; can react with oxidizing materials. See also ALDEHYDES.
Metabolism
In the animal body heliotropin undergoes the expected metabolic reaction involving oxidation to the corresponding acid (Williams, 1959).
Purification Methods
Crystallise piperonal from aqueous 70% EtOH or EtOH/water. [Beilstein 19/4 V 225.]
Piperonyl aldehyde Preparation Products And Raw materials
Raw materials
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