Methyl 3-mercaptopropionate
- CAS No.
- 2935-90-2
- Chemical Name:
- Methyl 3-mercaptopropionate
- Synonyms
- METHYL 3-MERCAPTOPROPANOATE;Methyl mercaptopropionate;Methyl 3-sulfanylpropanoate;3-MERCAPTOPROPIONIC ACID METHYL ESTER;Mercaptomethyl;Methyl 3-thiopropanoate;Methyl 3-mercaptopro;Zavegepant Impurity 61;Methyl 3-Mercaptopropion;METHYL 3-MERCAPTOPROPIONATE
- CBNumber:
- CB3262607
- Molecular Formula:
- C4H8O2S
- Molecular Weight:
- 120.17
- MOL File:
- 2935-90-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/9/3 18:36:42
| Melting point | 38 °C(Solv: ethyl ether (60-29-7); ligroine (8032-32-4)) |
|---|---|
| Boiling point | 54-55 °C/14 mmHg (lit.) |
| Density | 1.085 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 140 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Chloroform, Ethyl Acetate |
| pka | 9.17±0.25(Predicted) |
| form | Liquid |
| color | Clear colorless |
| Water Solubility | Soluble in water. |
| BRN | 1742952 |
| LogP | 0.870 (est) |
| CAS DataBase Reference | 2935-90-2(CAS DataBase Reference) |
| NIST Chemistry Reference | Propanoic acid, 3-mercapto-, methyl ester(2935-90-2) |
| EPA Substance Registry System | Propanoic acid, 3-mercapto-, methyl ester (2935-90-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301+H331-H312-H410 | |||||||||
| Precautionary statements | P261-P273-P280-P301+P310-P302+P352+P312-P304+P340+P311 | |||||||||
| Hazard Codes | T,Xi | |||||||||
| Risk Statements | 22-23-36/37/38 | |||||||||
| Safety Statements | 45-37/39-26 | |||||||||
| RIDADR | UN 1993 3/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UA2465980 | |||||||||
| F | 13 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29309090 | |||||||||
| NFPA 704 |
|
Methyl 3-mercaptopropionate price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 108987 | Methyl 3-mercaptopropionate 98% | 2935-90-2 | 5G | ₹4189.28 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 108987 | Methyl 3-mercaptopropionate 98% | 2935-90-2 | 100G | ₹5282.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 108987 | Methyl 3-mercaptopropionate 98% | 2935-90-2 | 500G | ₹16118.43 | 2022-06-14 | Buy |
| ALFA India | ALF-B20718-22 | Methyl 3-mercaptopropionate, 98% | 2935-90-2 | 100g | ₹5205 | 2022-05-26 | Buy |
| TCI Chemicals (India) | M1434 | Methyl 3-Mercaptopropionate min. 98.0 % | 2935-90-2 | 25G | ₹2100 | 2022-05-26 | Buy |
Methyl 3-mercaptopropionate Chemical Properties,Uses,Production
Chemical Properties
CLEAR COLORLESS LIQUID
Uses
Methyl 3-Mercaptopropionate is used in the synthesis of thioisoindolinones.
Application
Methyl 3-mercaptopropionate is an important chemical raw material. It is an intermediate for preparing isothiazolinone and a raw material for preparing fine chemical 4-chloro-7-methylthiophene [3,2-D ] pyrimidine. The methyl 3-mercaptopropionate is a raw material for synthesizing a simvastatin side DMB-S-MMP3- [ (2, 2-dimethyl-1-oxobutyl) sulfur ] methyl propionate serving as a blood fat-reducing drug by an enzyme method. Simvastatin is listed in the essential drug list of the World Health Organization and belongs to one of the essential drugs of the basic medical system.
Synthesis
The traditional synthetic method of the Methyl 3-mercaptopropionate comprises the steps of adding 2% -5% of concentrated sulfuric acid as a catalyst in an inert atmosphere, refluxing (65-70 ℃) for a reaction for 15 hours, evaporating reaction liquid to remove methanol after the reaction is finished, and then deacidifying; during the deacidification process, a large amount of deionized water is added for water washing, and when the pH of the water washing solution is close to neutrality, the Methyl 3-mercaptopropionate product is obtained by reduced pressure distillation. Another method for preparing Methyl 3-mercaptopropionate is by using a reactive distillation technology. Mix the reactant 3-mercaptopropionic acid and methanol, then perform pre-reaction through a fixed bed reactor filled with a catalyst to obtain a crude product of the methyl 3-mercaptopropionate. The crude product is pumped to the middle part of the reaction rectifying tower by a feeding pump and is input; fresh methanol and a water-carrying agent are input from the lower part of the reaction rectifying tower, a catalyst is arranged at the lower part of the reaction rectifying tower, and unreacted 3-mercaptopropionic acid in the crude product continuously reacts with methanol in a catalyst bed layer of the reaction rectifying tower; after the reaction is finished, excess methanol, water carrying agent and water are extracted from the upper part of the reaction rectifying tower, and the product Methyl 3-mercaptopropionate is extracted from the bottom of the tower.
Methyl 3-mercaptopropionate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Qingdao RENAS Polymer Material Co., Ltd. | +86-0532-86867058 +86-18562606086 | China | 286 | 58 | Inquiry |
| Shaoxing Fangxiao Chemical Co., LTD | +86-13456999252 +86-13868192239 | China | 50 | 58 | Inquiry |
| Qingdao Zhongke Huatai Industrail Co., Ltd. | +86-532-86898076 +86-15153292017 | China | 25 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12446 | 58 | Inquiry |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | China | 5866 | 58 | Inquiry |
| Chongqing Zhihe Biopharmaceutical Co., Ltd. | +8618580541567 | China | 303 | 58 | Inquiry |
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