Cromolyn Disodium Salt
- CAS No.
- 15826-37-6
- Chemical Name:
- Cromolyn Disodium Salt
- Synonyms
- SODIUM CROMOGLYCATE;CROMOLYN SODIUM;SODIUM CROMOGLICATE;Cromoglycate;Cromoglycate Sodium;DISODIUM CROMOGLYCATE;DSCG;intal;Allergocrom;SODIUM CHROMOGLICATE
- CBNumber:
- CB3413920
- Molecular Formula:
- C23H17NaO11
- Molecular Weight:
- 492.37
- MOL File:
- 15826-37-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:06
| Melting point | 241-2420C (dec) |
|---|---|
| storage temp. | 2-8°C |
| solubility | Soluble in water, practically insoluble in ethanol (96 per cent). |
| form | Solid |
| color | White to Off-White |
| Water Solubility | Soluble in water to 100mg/ml |
| Merck | 14,2590 |
| Stability | Hygroscopyc |
| InChIKey | VLARUOGDXDTHEH-UHFFFAOYSA-L |
| CAS DataBase Reference | 15826-37-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | 3249 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | DJ2380000 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29329990 | |||||||||
| Toxicity | LD50 in mice, rats (mg/kg): >8000 orally (Cox) | |||||||||
| NFPA 704 |
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Cromolyn Disodium Salt price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C0399 | Cromolyn sodium salt ≥95% | 15826-37-6 | 1G | ₹6408.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR2727 | Cromolyn Sodium Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 1?g | 15826-37-6 | 1G | ₹22764.98 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C0399 | Cromolyn sodium salt ≥95% | 15826-37-6 | 5G | ₹23923.25 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C0399 | Cromolyn sodium salt ≥95% | 15826-37-6 | 25G | ₹93073.35 | 2022-06-14 | Buy |
| TCI Chemicals (India) | C2521 | Cromolyn Disodium Salt | 15826-37-6 | 5G | ₹9200 | 2022-05-26 | Buy |
Cromolyn Disodium Salt Chemical Properties,Uses,Production
Chemical Properties
White Crystalline Powder
Uses
Chromone complex which blocks mast cell degranulation
Definition
ChEBI: An organic sodium salt that is the disodium salt of cromoglycic acid.
Indications
Cromolyn sodium (Intal) is chemically related drugs called chromones that is used for the prophylaxis of mild or moderate asthma. It is administered by inhalation and has very good safety profiles, making them particularly useful in treating children.
General Description
Cromolyn sodium, disodium 1,3-bis(2-carboxychromon-5-yloxy)-2-hydroxypropane (Intal), isa hygroscopic, white, hydrated crystalline powder that is solublein water (1:10). It is tasteless at first but leaves a veryslightly bitter aftertaste. The pK of cromolyn is 2. It is availableas a solution for a nebulizer, an aerosol spray, a nasal solution,an ophthalmic solution, and an oral concentrate.
Nebulized and aerosol cromolyn has been used for prophylacticmanagement of bronchial asthma and prevention ofexercise-induced bronchospasm. Cromolyn nasal solution isused for the prevention and treatment of allergic rhinitis, andoral concentrate is used to treat the histaminic symptomsof mastocytosis (diarrhea, flushing, headaches, vomiting, urticaria,abdominal pain, nausea, and itching). Topical cromolyn(eye drops) is used to treat allergic conjunctivitis andkeratitis. In the treatment of asthma, cromolyn efficacy is manifestedby decreased severity of clinical symptoms, or need for concomitant therapy, or both. Long-term use is justified if thedrug significantly reduces the severity of asthma symptoms;permits a significant reduction in, or elimination of, steroiddosage; or improves management of those who have intolerableside effects to sympathomimetic agents or methylxanthines.For cromolyn to be effective, it must be administered atleast 30 minutes prior to antigen challenge and administered atregular intervals (see dosing information that follows). Wheninhaled, the powder does produce irritation in some patients.Also, overuse of cromolyn can result in tolerance.
Mechanism of action
The precise mechanism or mechanisms whereby cromolyn sodium and nedocromil sodium exert their antiasthmatic activities is unknown. Early work suggested that these agents act by “stabilizing” mast cells, preventing mediator release. However, several other compounds exhibit greater potency for stabilization of mast cells yet possess no clinical efficacy in asthma.This suggests that the therapeutic activity of cromolyn sodium and nedocromil sodium in asthma is related to one or more other pharmacological mechanisms. Postulates include inhibitory effects on irritant receptors, nerves, plasma exudation, and inflammatory cells in general.
Pharmacokinetics
Cromolyn sodium is a bischromone that contains the fundamental benzopyrone moiety of khellin. The two chromone rings are necessary for activity and must be coplanar, with a linking chain of no longer than six carbons. If one changes the linking chain to positions 8 and 8′, coplanarity cannot be maintained, and the compound loses all activity. Cromolyn sodium is poorly absorbed from the lungs (~8%), insignificantly from the eye (~0.07%), and by approximately 1% from the GI tract. What little that finds its way into systemic circulation is eliminated intact in the urine and the bile. For the treatment of asthma, cromolyn sodium is available as a solution for both intranasal and inhalation administration. There also is an oral concentrate (100 mg/5 mL), which is administered as a 200-mg dose given four times a day.
Clinical Use
Cromolyn sodium is used almost exclusively for the prophylactic treatment of mild to moderate asthma and should not be used for the control of acute bronchospasm. This agent is effective in about 60 to 70% of children and adolescents with asthma. Unfortunately, there is no reliable means to predict which patients will respond.It is less effective in older patients and in patients with severe asthma. It may take up to 4 to 6 weeks of treatment for cromolyn sodium to be effective in chronic asthma, but it is effective after a single dose in exercise-induced asthma. With respect to clinical efficacy, cromolyn sodium and nedocromil sodium do not differ in a substantial way.
Side effects
Cromolyn sodium is the least toxic of available therapies for asthma. Adverse reactions are rare and generally minor. Those occurring in fewer than 1 in 10,000 patients include transient bronchospasm, cough or wheezing, dryness of throat, laryngeal edema, swollen parotid gland, angioedema, joint swelling and pain, dizziness, dysuria, nausea, headache, nasal congestion, rash, and urticaria.
Cromolyn Disodium Salt Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| JIVICHEM SYNTHESIS PVT LTD | +91-7028392790 +91-7028392790 | Maharashtra, India | 337 | 58 | Inquiry |
| S.V ENTERPRISES | +919322701159 | Mumbai, India | 150 | 58 | Inquiry |
| FDC Limited | +912226782653 | Mumbai, India | 30 | 58 | Inquiry |
| Integrin Life Sciences. Pvt. Ltd. | +91-4040265469 +91-9849990870 | Hyderabad, India | 90 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Mesha Pharma Private Limited | 08048372569Ext 806 | Mumbai, India | 133 | 58 | Inquiry |
| Lara Drugs Private Limited | 08048372269Ext 569 | Hyderabad, India | 6 | 58 | Inquiry |
| Kebee Pharmachemie Pvt., Ltd. | 91-22-28328669 | Maharashtra, India | 65 | 58 | Inquiry |
| Newedge Overseas | 91-79-40307106 | Gujarat, India | 109 | 58 | Inquiry |
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