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Clindamycin palmitate hydrochloride

Clindamycin palmitate hydrochloride Structure
CAS No.
25507-04-4
Chemical Name:
Clindamycin palmitate hydrochloride
Synonyms
Clindmycin;Cleocin Pediatric;Clindamycin Impurity 85;CLINDAMYCIN PALMITATE HCL;Clindamycin 2-Palmitate HCl;ClindaMycin PalMitate HCl USP;Clindamycin Hydrochloride Palmitate;Clindamycin palmitate hydrochloride;clindamycin2’-palmitatehydrochloride;Clindamycin Palmitate Hydrochloride (USP)
CBNumber:
CB3666368
Molecular Formula:
C34H64Cl2N2O6S
Molecular Weight:
699.85
MOL File:
25507-04-4.mol
Modify Date:
2023/12/19 16:21:16

Clindamycin palmitate hydrochloride Properties

Melting point 141-143°C
storage temp. -20°C Freezer, Under Inert Atmosphere
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
color White to Off-White
InChIKey GTNDZRUWKHDICY-ZLNNALEKSA-N

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H319
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P
HS Code  2941906000
NFPA 704
0
2 0

Clindamycin palmitate hydrochloride Chemical Properties,Uses,Production

Description

Clindamycin palmitate is a water-soluble prodrug form of the antibiotic clindamycin . It undergoes rapid hydrolysis in vivo to release active clindamycin. Formulations containing clindamycin palmitate have been used in the treatment of various bacterial infections.

Chemical Properties

White Solid

Uses

antibacterial (tuberculostatic)

General Description

Clindamycin palmitate hydrochloride (Cleocin Pediatric) isthe hydrochloride salt of the palmitic acid ester ofcleomycin. The ester bond is to the 2-hydroxyl group of thelincosamine sugar. The ester serves as a tasteless prodrugform of the antibiotic, which hydrolyzes to clindamycin inthe plasma. The salt form confers water solubility to theester, which is available as granules for reconstitution intoan oral solution for pediatric use. Although absorption of thepalmitate is slower than that of the free base, there is littledifference in overall bioavailability of the two preparations.Reconstituted solutions of the palmitate hydrochloride arestable for 2 weeks at room temperature. Such solutionsshould not be refrigerated because thickening occurs thatmakes the preparation difficult to pour.

Global( 190)Suppliers
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Mylan Laboratories Ltd +91-4023550543 +91-4030866666 Telangana, India 150 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
LUPIN LTD +91 124 4885000 / +91 124 3325000 New Delhi, India 191 58 Inquiry
AUROBINDO PHARMA LTD +91 (40) 6672 1200 New Delhi, India 209 58 Inquiry
Hebei Mojin Biotechnology Co., Ltd +8613288715578 China 12456 58 Inquiry
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Hefei TNJ Chemical Industry Co.,Ltd. +86-0551-65418679 +86-18949832763 China 2989 55 Inquiry
Hebei Guanlang Biotechnology Co., Ltd. +86-19930503282 China 8826 58 Inquiry
Clindmycin clindamycin2’-palmitatehydrochloride Methyl7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-alpha-D-galacto-octopyranoside2-hexadecanoatemonohydrochloride Clindamycin palmitate hydrochloride Clindamycin Palmitate Hydrochloride (500 mg) Clindamycin Palmitate Hydrochloride (500 mg)G0D334586ug/mg(an) ClindaMycin PalMitate HCl USP methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio- 2-hexadecanoate-L-threo-α-D-galacto-octopyranoside,monohydrochloride Clindamycin Hydrochloride Palmitate Clindamycin 2-Palmitate HCl CLINDAMYCIN PALMITATE HCL Methyl 7-Chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl] carbonyl]amino]-1-thio-L-threo-α-D-galactooctopyranoside 2-Hexadecanoate Monohydrochloride hexadecanoic acid [6-[2-chloro-1-[[(1-methyl-4-propyl-2-pyrrolidinyl)-oxomethyl]amino]propyl]-4,5-dihydroxy-2-(methylthio)-3-oxanyl] ester Cleocin Pediatric Clindamycin Palmitate Hydrochloride (USP) Clindmycin palmitate hydrochloride USP/EP/BP Clindamycin palmitate hydrochloride USP/EP/BP Clindamycin Palmitate Hydrochloride (1137005) Clindamycin Impurity 85 25507-04-4 C34H63CIN2O6SHCL C18H33ClN2O5SHClC18H34Cl2 C34H64Cl2N2O6S C34H64Cl2N2O5S Inhibitors PHENYPASTEBAMIN