Amrinone
- CAS No.
- 60719-84-8
- Chemical Name:
- Amrinone
- Synonyms
- inocor;AMRINONE;win40680;Cartonic;Vesistol;Wincoram;Imrinone;awd08-250;Amirinone;INAMRINONE
- CBNumber:
- CB3774164
- Molecular Formula:
- C10H9N3O
- Molecular Weight:
- 187.2
- MOL File:
- 60719-84-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/8 9:02:54
| Melting point | 294-297°C (dec.) |
|---|---|
| Boiling point | 321.94°C (rough estimate) |
| Density | 1.2025 (rough estimate) |
| refractive index | 1.4830 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | DMF: 0.3 mg/ml; DMSO: 0.5 mg/ml |
| form | Crystals |
| pka | 12.05±0.10(Predicted) |
| color | Crystals from DMF |
| Water Solubility | Insoluble in water or chloroform. Slightly soluble in acetic acid or DMF. Soluble in DMSO |
| CAS DataBase Reference | 60719-84-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P301+P330+P331+P310 | |||||||||
| Hazard Codes | T,Xn | |||||||||
| Risk Statements | 25-36/37/38-20/21/22 | |||||||||
| Safety Statements | 28-45-36-26 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DW2500000 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29333999 | |||||||||
| Toxicity | LD50 orl-rat: 102 mg/kg NDADD8 1,259,83 | |||||||||
| NFPA 704 |
|
Amrinone Chemical Properties,Uses,Production
Description
Amrinone is a positive inotropic agent useful in the management of severe congestive heart failure. It is effective even in unresponsive, fully digitalized patients.
Chemical Properties
Crystalline Solid
Uses
Amrinone is used for short-term treatment of cardiac insufficiency that does not respond to treatment of other drugs.
General Description
During normal heart function, cAMP performsimportant roles in regulating intracellular calcium levels.That is, certain calcium channels and storage sites forcalcium must be activated by cAMP-dependant protein kinases.Because cAMP plays an indirect role in the contractilityprocess, agents that inhibit its degradation will providemore calcium for cardiac contraction. One phosphodiesteraseenzyme that is involved in the hydrolysis of myocardiumcAMP is F-III. Amrinone, 5-amino (3,4 -dipyridin)-6 1 (H)-one (Inocor), possesses positive isotropic effects as aresult of its ability to inhibit this phosphodiesterase. In 1999,the USP Nomenclature Committee and the United StatesAdopted Names (USAN) Council approved changing thenonproprietary name and the current official monograph titleof amrinone to inamrinone. This change in nomenclature wasa result of amrinone being confused with amiodarone becauseof the similarity of the names. This was reported to cause confusionbetween the products that led to medication errors,some of which resulted in serious injury or death.
Safety Profile
Poison by ingestion andintravenous routes. Human systemic effects by ingestion:cardiac arrhythmias, liver function, thrombocytopenia. Anexperimental teratogen. Other experimental reproductiveeffects. When heated to decomposition it emits toxicfumes o
Amrinone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Indogulf Group | 91-22-23455220 | Maharashtra, India | 249 | 58 | Inquiry |
| Swapnroop Drugs & Pharmaceuticals | +91 (240) 664-1875 | New Delhi, India | 91 | 50 | Inquiry |
| Shivam Pharma Chemicals | 91-22-26403900 | Maharashtra, India | 656 | 58 | Inquiry |
| Maas Pharma Chemicals | +91-9958666224 | Delhi, India | 1607 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Excel International | 08048957044 | Mumbai, India | 36 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21669 | 55 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29898 | 58 | Inquiry |
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