Phenolphthalein
- CAS No.
- 77-09-8
- Chemical Name:
- Phenolphthalein
- Synonyms
- PHENOLPHTALEIN;Fenolftalein;phenolphtaleine;PHENOLPHTHALEIN INDICATOR SOLUTION;3,3-bis(4-hydroxyphenyl)isobenzofuran-1(3H)-one;colax;phthalin;alpha-di(p-hydroxyphenyl)phthalide;2-[Bis(4-hydroxyphenyl)methyl]benzoic acid;.alpha, alpha.-Di(p-hydroxyphenyl)phthalide
- CBNumber:
- CB4141228
- Molecular Formula:
- C20H14O4
- Molecular Weight:
- 318.32
- MOL File:
- 77-09-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/11/15 19:19:13
| Melting point | 261-263 °C (lit.) |
|---|---|
| Boiling point | 417.49°C (rough estimate) |
| Density | 1.27 g/cm3 at 32 °C |
| refractive index | 1.5400 (estimate) |
| Flash point | 24 °C |
| storage temp. | no restrictions. |
| solubility | Soluble in alcohol. Slightly soluble in ether. Slightly soluble in dimethyl sulfoxide and insoluble in benzene or hexane. |
| form | Solid |
| pka | 9.4(at 25℃) |
| Colour Index | 764 |
| color | White to yellow-white |
| PH Range | 8.0(colorless)-10(Red) |
| PH | 7.8～10.0 |
| Odor | Odorless |
| Water Solubility | <0.1 g/100 mL |
| λmax | 552nm, 553nm, 374nm, 205nm, 229nm, 276nm |
| Merck | 14,7243 |
| BRN | 284423 |
| Stability | Stable. Incompatible with strong oxidizing agents, alkalies. |
| Major Application | Display device, sensors, semiconductors, fuel cells, photoreceptors, electronic packaging, authentication system for secure documents, inks, correction fluid, paints, detection of defects in films, floor coatings, textiles, corrosion testing, explosive, concrete, toys, detecting lipase activity of crop seeds, soaps, method for prevention of drugmisuse, cosmetics, diapers, detecting viable cells, carbohydrates, antimalarial, treating amyloid-associated diseases |
| LogP | 2.410 |
| CAS DataBase Reference | 77-09-8(CAS DataBase Reference) |
| IARC | 2B (Vol. 76) 2000 |
| NIST Chemistry Reference | Phenolphthalein(77-09-8) |
| EPA Substance Registry System | 3,3-Bis(4-hydroxyphenyl)phthalide (77-09-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H341-H350-H361f | |||||||||
| Precautionary statements | P202-P264-P280-P302+P352-P308+P313-P332+P313 | |||||||||
| Hazard Codes | Xn,T,F,Xi | |||||||||
| Risk Statements | 40-22-10-36/38-23/25-11-36/37/38-68-62-45-39/23/24/25-23/24/25 | |||||||||
| Safety Statements | 45-36/37-33-24-16-7-36-26-53 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | SM8380000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29322910 | |||||||||
| NFPA 704 |
|
Phenolphthalein price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 319236 | Phenolphthalein solution 0.5?wt. % in ethanol: water (1:1) | 77-09-8 | 100ML | ₹2447.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 105945 | Phenolphthalein ACS reagent | 77-09-8 | 100G | ₹6646.55 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 319236 | Phenolphthalein solution 0.5?wt. % in ethanol: water (1:1) | 77-09-8 | 6X100ML | ₹12262.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 105945 | Phenolphthalein ACS reagent | 77-09-8 | 500G | ₹19907.18 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 105945 | Phenolphthalein ACS reagent | 77-09-8 | 2.5KG | ₹24843.38 | 2022-06-14 | Buy |
Phenolphthalein Chemical Properties,Uses,Production
Chemical Properties
white to light yellow crystal powde
Uses
Phenolphthalein can be used as an inhibitor and pH indicator. It also induces centrosome amplification and tubulin depolymerization in vitro.
Definition
phenolphthalein: A dye used as anacid-base indicator. It is colourlessbelow pH 8 and red above pH 9.6. Itis used in titrations involving weakacids and strong bases. It is also usedas a laxative.
World Health Organization (WHO)
Phenolphthalein has been widely used as a laxative since its cathartic activity was first described in 1902. Because it undergoes enterohepatic circulation it is eliminated slowly and it has been associated with adverse effects, notably skin reactions, potassium loss and atonia. This has led to the withdrawal of phenolphthalein from pharmaceutical preparations in several countries. Elsewhere, it remains available, often in over-the-counter preparations.
General Description
Phenolphthalein solution is a synthetic indicator. It is colorless in acidic and neutral conditions. Phenolphthalein gives pink color when added to a base, therefore it is considered as a base indicator.
Safety Profile
Confirmed carcinogen. US Food and Drug Administration recommends removal from laxative formulations. Moderately toxic by intraperitoneal route. Human systemic effects: changes in urine composition, gastritis, nausea or vomiting. Used in medicine as a laxative; in chemistry as an indicator. When heated to decomposition it emits acrid smoke and irritating fumes
Carcinogenicity
Phenolphthalein is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
Purification Methods
Dissolve it in EtOH (7mL/g), then dilute it with eight volumes of cold water, filter and heat on a water-bath to remove most of the alcohol and the phenolphthalein that precipitates is filtered off and dried in vacuo.[Beilstein 18 II 119, 18 III/1V 1945, 18/4 V 188.]
Phenolphthalein Preparation Products And Raw materials
Raw materials
Preparation Products
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4535 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3753 | 58 | Inquiry |
| Merck Ltd | +91-2262109800 +91-2262109000 | Maharashtra, India | 272 | 58 | Inquiry |
| Heni Chemical Industries (Heni Drugs Pvt Ltd) | +91-2261192711 +91-8879618643 | Maharashtra, India | 25 | 58 | Inquiry |
| RYZE CHEMIE | +91-9702966440 +91-9702966440 | Maharashtra, India | 335 | 58 | Inquiry |
| Titan Biotech Limited | 09711169006 | Delhi, India | 196 | 58 | Inquiry |
| Techno Pharmchem | 91-9818265860 | Delhi, India | 173 | 58 | Inquiry |
| Oster Chemical & Pharmaceutical Works Pvt. Ltd. | 91-33-23508577 | Kolkata, India | 101 | 58 | Inquiry |
| Belami Fine Chemicals Pvt. Ltd. | 91-22-22051092 | Maharashtra, India | 89 | 58 | Inquiry |
| Mala International | 08068442326Ext 398 | Mumbai, India | 165 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| GLR Innovations | 58 |
| JSK Chemicals | 58 |
| Merck Ltd | 58 |
| Heni Chemical Industries (Heni Drugs Pvt Ltd) | 58 |
| RYZE CHEMIE | 58 |
| Titan Biotech Limited | 58 |
| Techno Pharmchem | 58 |
| Oster Chemical & Pharmaceutical Works Pvt. Ltd. | 58 |
| Belami Fine Chemicals Pvt. Ltd. | 58 |
| Mala International | 58 |
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