PLUMBAGIN
- CAS No.
- 481-42-5
- Chemical Name:
- PLUMBAGIN
- Synonyms
- plumagin;plumbapin;PLUMBAGAN;PLUMBAGIN;Plumbaein;plumbagone;NSC 236613;NSC 688284;Plumbagine;Ophioxylin
- CBNumber:
- CB4144779
- Molecular Formula:
- C11H8O3
- Molecular Weight:
- 188.18
- MOL File:
- 481-42-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/1 18:08:31
| Melting point | 76-78 °C(lit.) |
|---|---|
| Boiling point | 283.17°C (rough estimate) |
| Density | 1.354 |
| refractive index | 1.6310 (estimate) |
| storage temp. | -20°C |
| solubility | very faint turbidity in hot Methanol |
| pka | 6.70±0.20(Predicted) |
| form | Crystals or Crystalline Powder |
| color | Orange |
| Merck | 7538 |
| Stability | Hygroscopic |
| LogP | 2.450 (est) |
| EPA Substance Registry System | 1,4-Naphthalenedione, 5-hydroxy-2-methyl- (481-42-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P310-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25-34-36/37/38 | |||||||||
| Safety Statements | 22-26-36/37/39-45-37/39-28A | |||||||||
| RIDADR | UN 2923 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | QL8500000 | |||||||||
| Hazard Note | Toxic | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29146990 | |||||||||
| Toxicity | LD50 i.p. in mice: ~0.015 g/kg (Debray) | |||||||||
| NFPA 704 |
|
PLUMBAGIN price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | P7262 | Plumbagin from Plumbago indica | 481-42-5 | 100MG | ₹2662.95 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P7262 | Plumbagin from Plumbago indica | 481-42-5 | 250MG | ₹5163.53 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P7262 | Plumbagin from Plumbago indica | 481-42-5 | 1G | ₹14234.88 | 2022-06-14 | Buy |
| TCI Chemicals (India) | P1139 | Plumbagin | 481-42-5 | 1G | ₹10000 | 2022-05-26 | Buy |
| ottokemi | P 4813 | Plumbagin, from plumbago indica | 481-42-5 | 100mg | ₹2304 | 2022-05-26 | Buy |
PLUMBAGIN Chemical Properties,Uses,Production
Description
Plumbagin is a natural 1,4-naphthoquinone first isolated from plants of the genus Plumbago. It has diverse effects in cells and animals. Plumbagin causes the generation of reactive oxygen species and induces apoptosis in cancer cells. It activates signaling through Nrf2 and the antioxidant response element, inducing the expression of Nrf2 target genes, including NQO1 and heme oxygenase-1 in cultured neuronal cells. Plumbagin also inhibits NADPH oxidase 4 in a time- and dose-
Chemical Properties
ORANGE CRYSTALLINE POWDER OR CRYSTALS
Uses
Plumbagin from Plumbago indica has been used:
- as a reactive oxygen species agent (ROS) to induce cytotoxicity in mouse embryonic fibroblasts
- as an oxidative stress inducer to generate superoxide anion in Saccharomyces cerevisiae
- as a reference standard in thin layer chromatography and in spectrophotometric analysis for quantification of plumbagin in Plumbago auriculate samples
Definition
ChEBI: A hydroxy-1,4-naphthoquinone that is 1,4-naphthoquinone in which the hydrogens at positions 2 and 5 are substituted by methyl and hydroxy groups, respectively.
General Description
Plumbagin is a bioactive naphthoquinone present majorly in Plumbago indica L. It is a quinoid and is also derived from the roots of Plumbago zeylanica?roots.
Purification Methods
It crystallises in yellow needles from aqueous EtOH. It is soluble in organic solvents, it is steam volatile and it sublimes on heating in a vacuum. [Fieser & Dunn J Am Chem Soc 58 572 1936, Beilstein 8 III 2576, 8 IV 2376.]
PLUMBAGIN Preparation Products And Raw materials
Raw materials
1,4-Diamino-2,3-dihydroanthraquinone
N-Bromosuccinimide
Tin tetrachloride
1,5-Dihydroxy naphthalene
Acetyl chloride
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Global( 224)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| Biosyn Research Chemicals | +91-91-9346022300 +91-9346022300 | Telangana, India | 465 | 58 | Inquiry |
| Otto Chemie Pvt Ltd | +91-2222070099 +91-2266382599 | Maharashtra, India | 429 | 58 | Inquiry |
| CHEMAZON LABORATORIES | +91 9848551964 | Hyderabad, India | 1320 | 58 | Inquiry |
| AVIGYABIOSCIENCES PRIVATE LIMITED | +91-9849533087 +91-9849533087 | Telangana, India | 156 | 58 | Inquiry |
| Biosyn Research Chemicals | +91 9346022300/+91 9399339999 | Telangana, India | 1340 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| GLR Innovations | 58 |
| Biosyn Research Chemicals | 58 |
| Otto Chemie Pvt Ltd | 58 |
| CHEMAZON LABORATORIES | 58 |
| AVIGYABIOSCIENCES PRIVATE LIMITED | 58 |
| Biosyn Research Chemicals | 58 |
| A.J Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| Otto Chemie Pvt. Ltd. | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
481-42-5(PLUMBAGIN)Related Search:
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plumbagone
1,4-Dihydro-1,4-dioxo-5-hydroxy-2-methylnaphthalene
Plumbagin (natural)
PLUMBAGIN PRACTICAL GRADE
Plumbagin, 99+%
PLUMBAGIN(RG)
1,4-NAPHTHALENEDIONE,5-HYDROXY-2-METHYL
PLANT STEROLS KIT
plumbapin
Plumbagin from Plumbago indica
Plumbagin,95%
Plumbagin ,97%
NSC 236613
NSC 688284
Plumbagine
5-hydroxy-2-methyl-4-naphthalenedione
5-hydroxy-2-methyl-4-naphthoquinone
2-Methyl-5-hydroxy-1,4-naphthalenedione
1,4-Dihydro-1,4-dioxo-5-hydroxy-2-methylnaphthalene, 5-Hydroxy-2-methyl-1,4-naphthoquinone
5-Hydroxy-2-methylnaphthalene-1,4-dione
1,4-Dihydro-1,4-dioxo-5-hydroxy-2-methylnaphthalene, 5-Hydroxy-2-methyl-1,4-naphthoquinone, Plumbagin
Ophioxylin
PLUMBAGIN FROM FROM PLUMBAGO INDICA
5-HYDROXY-2-METHYL-1,4-NAPHTHOQUINONE
5-HYDROXY-2-METHYL-1,4-NAPTHOQUINONE
PLUMBAGAN
PLUMBAGIN
SPECS AP-782/41885488
RARECHEM BW GA 0426
2-methyl-5-hydroxy-1,4-naphthoquinone
2-methyljuglone
5-hydroxy-2-methyl-1,4-naphthalenedione
5-hydroxy-2-methyl-1,4-dihydronaphthalene-1,4-dione
Plumbagin>
Plumbaein
5-Hydroxy-2-methyl-1,4-naphthochinon
Plumbagin (2-Methyljuglone)
5-Hydroxy-2-methylnaphthalene-1,4-dione(Plumbagin)
plumagin
481-42-5
C11H8O3
Cancer Research
Chemopreventive Agents
BioChemical
Anti-proliferative Agents
Inhibitors
Anthraquinones, Hydroquinones and Quinones
chem-chemical