1-(3,6-DIBROMO-9H-CARBAZOL-9-YL)-3-(DIMETHYLAMINO)PROPAN-2-OL
- CAS No.
- 253449-04-6
- Chemical Name:
- 1-(3,6-DIBROMO-9H-CARBAZOL-9-YL)-3-(DIMETHYLAMINO)PROPAN-2-OL
- Synonyms
- WISKOSTATIN;Wiskostatin, 10 mM in DMSO;Wiskostatin, N-WASP inhibitor;Wiskostatin - CAS 253449-04-6 - Calbiochem;1-(3,6-dibromocarbazol-9-yl)-3-(dimethylamino)propan-2-ol;3,6-Dibromo-α-[(dimethylamino)methyl]-9H-cabazole-9-ethanol;3,6-Dibromo-α-[(dimethylamino)methyl]-9H-carbazole-9-ethanol;1-(3,6-DIBROMO-9H-CARBAZOL-9-YL)-3-(DIMETHYLAMINO)PROPAN-2-OL;9H-Carbazole-9-ethanol, 3,6-dibromo-α-[(dimethylamino)methyl]-;1-(3,6-Dibromo-9H-carbazol-9-yl)-3-(dimethylamino)propan-2-ol 97%
- CBNumber:
- CB4347723
- Molecular Formula:
- C17H18Br2N2O
- Molecular Weight:
- 426.15
- MOL File:
- 253449-04-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/1/27 9:38:02
| Melting point | 153-155 |
|---|---|
| Boiling point | 320.2±22.0 °C(Predicted) |
| Density | 1.62±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble10mg/mL, clear |
| pka | 14.40±0.20(Predicted) |
| form | White solid |
| color | white to beige |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
1-(3,6-DIBROMO-9H-CARBAZOL-9-YL)-3-(DIMETHYLAMINO)PROPAN-2-OL price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | W2270 | Wiskostatin | 253449-04-6 | 5MG | ₹15458.1 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W2270 | Wiskostatin | 253449-04-6 | 25MG | ₹62081.38 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 681525 | Wiskostatin - CAS 253449-04-6 - Calbiochem A cell-permeable N-alkylated carbazole derivative that selectively blocks actin filament assembly. | 253449-04-6 | 1MG | ₹17660.01 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 681525 | Wiskostatin - CAS 253449-04-6 - Calbiochem A cell-permeable N-alkylated carbazole derivative that selectively blocks actin filament assembly. | 253449-04-6 | 5MG | ₹55560 | 2022-06-14 | Buy |
1-(3,6-DIBROMO-9H-CARBAZOL-9-YL)-3-(DIMETHYLAMINO)PROPAN-2-OL Chemical Properties,Uses,Production
Uses
Wiskostatin has been used:
- as a small-molecule inhibitor of Wiskott-Aldrich syndrome protein (WASP) in human osteosarcoma U2OS cells and mouse-tail fibroblast cell lines
- as a neural (N)-WASP inhibitor in cultured neurons and in the human embryonic kidney (HEK293) cells expressing HA-Parkin
- as a neural (N)-WASP inhibitor in dorsal root ganglion (DRG) cells to investigate vascular endothelial growth factor (VEGF) effect on the actin related protein 2/3 complex (Arp 2/3)
General Description
Wiskostatin is a dibrominated carbazole. The N-alkylated side chain has a chiral hydroxyl group and a terminal tertiary amine.
Biochem/physiol Actions
Wiskostatin is a selective inhibitor of N-WASP, a ubiquitously expressed member of the Wiskott-Aldrich Syndrome protein (WASp) family that regulates actin polymerization. Wiskostatin inhibits actin-dependent cellular functions, including migration, transmembrane transport and phagocytosis.
1-(3,6-DIBROMO-9H-CARBAZOL-9-YL)-3-(DIMETHYLAMINO)PROPAN-2-OL Preparation Products And Raw materials
Raw materials
Preparation Products
1-(3,6-DIBROMO-9H-CARBAZOL-9-YL)-3-(DIMETHYLAMINO)PROPAN-2-OL Suppliers
Global( 102)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 32159 | 58 | Inquiry |
| Aceschem Inc. | +1-817863-6948 +1-（817）863-6948 | United States | 19632 | 58 | Inquiry |
| Aladdin Scientific | United States | 57505 | 58 | Inquiry | |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +8617705817739 | China | 53881 | 58 | Inquiry |
| ABCR GmbH & CO. KG | 49 721 95061 0 | Germany | 6831 | 75 | Inquiry |
| United States Biological | 800.520.3011 or 781.639.5092 | United States | 6214 | 80 | Inquiry |
| Merck Millipore | 1-400-889-1988 400-889-1988 | China | 59839 | 58 | Inquiry |
| Shanghai Maclean Biochemical Technology Co., LTD | 021-50706066 15221275939 | China | 29784 | 58 | Inquiry |
| Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | China | 233051 | 58 | Inquiry |
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1-(3,6-DIBROMO-9H-CARBAZOL-9-YL)-3-(DIMETHYLAMINO)PROPAN-2-OL
9H-Carbazole-9-ethanol, 3,6-dibroMo-alpha-[(diMethylaMino)Methyl]-
WISKOSTATIN
3,6-Dibromo-9-[3-(dimethylamino)-2-hydroxyprop-1-yl]-9H-carbazole, 3-(3,6-Dibromo-9H-carbazol-9-yl)-N,N-dimethyl-2-hydroxypropylamine
1-(3,6-dibromocarbazol-9-yl)-3-(dimethylamino)propan-2-ol
3,6-Dibromo-α-[(dimethylamino)methyl]-9H-cabazole-9-ethanol
Wiskostatin - CAS 253449-04-6 - Calbiochem
1-(3,6-Dibromo-9H-carbazol-9-yl)-3-(dimethylamino)propan-2-ol 97%
9H-Carbazole-9-ethanol, 3,6-dibromo-α-[(dimethylamino)methyl]-
3,6-Dibromo-α-[(dimethylamino)methyl]-9H-carbazole-9-ethanol
Wiskostatin,neuronal,ATP,irreversible,Arp2/3 Complex,inhibit,N-WASP,selective,Inhibitor,Actin-related protein 2/3 complex,actin polymerization
Wiskostatin, N-WASP inhibitor
Wiskostatin, 10 mM in DMSO
253449-04-6
C17H18Br2N2O
Inhibitors