KGN
- CAS No.
- 4727-31-5
- Chemical Name:
- KGN
- Synonyms
- KGN;CS-612;100822;Kartogenin;KGN USP/EP/BP;Kartogenin(KGN);4'-Phenylphthalanilic Acid;n-Biphenyl-4-yl-phthalamic acid;4′-Phenyl-phthalanilic acid (8CI);2-[(Biphenyl-4-yl)carbaMoyl]benzoic Acid
- CBNumber:
- CB52622751
- Molecular Formula:
- C20H15NO3
- Molecular Weight:
- 317.34
- MOL File:
- 4727-31-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/9/20 16:43:00
| Melting point | 272 °C |
|---|---|
| Boiling point | 464.4±38.0 °C(Predicted) |
| Density | 1.289±0.06 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | DMSO: >15mg/mL |
| form | powder |
| pka | 3.45±0.36(Predicted) |
| color | White |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| InChIKey | SLUINPGXGFUMLL-UHFFFAOYSA-N |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H319-H410 | |||||||||
| Precautionary statements | P273-P305+P351+P338-P501 | |||||||||
| Hazard Codes | Xn,N | |||||||||
| Risk Statements | 22-36-50/53 | |||||||||
| Safety Statements | 60-61 | |||||||||
| RIDADR | UN 3077 9 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2916310090 | |||||||||
| NFPA 704 |
|
KGN price More Price(2)
KGN Chemical Properties,Uses,Production
Description
Kartogenin potently induces differentiation of human mesenchymal stem cells into chondrocytes with an EC50 value of 100 nM. Kartogenin induces chondrogenesis by binding the actin-
Uses
Kartogenin is a potent, selective, and non-cytotoxic downstream RUNX1 and RUNX2 modulator. Kartogenin causes mesenchymal stem cells found in joints to differentiate into chondrocyte cells that can build cartilage where it has been destroyed.
Biochem/physiol Actions
Kartogenin induces the selective differentiation of multipotent mesenchymal stem cells (MSCs) into chondrocytes. Kartogenin binds to filamin A, and disrupts the specific interaction between filamin A and CBFβ (core-binding factor β subunit). Apparently, kartogenin induces chondrogenesis by regulating the nuclear localization of CBFβ.
KGN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32835 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29899 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | CHINA | 21149 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 23499 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
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