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Cefpiramide acid

Cefpiramide acid Structure
CAS No.
70797-11-4
Chemical Name:
Cefpiramide acid
Synonyms
Cefpiramido;CEFPIRAMIDE;Cefpiramidum;cefpiramide acid;Suncefal：Sepatren;Cefpiramide (300 mg);Cefpiramide (1098118);Cefpiramide acid USP/EP/BP;Cefpiramidum|||Cefpiramido;7-aMino-3-(1-Methyl-1-pyrroleane oniuM acids)Methyl-2-oxacepheMs-2-Carboxylic Acid Hydrochloride
CBNumber:
CB5265046
Molecular Formula:
C25H24N8O7S2
Molecular Weight:
612.64
MOL File:
70797-11-4.mol
Modify Date:
2023/4/23 13:52:06
Request For Quotation

Cefpiramide acid Properties

Melting point 213-215° (dec)
Density 1.75±0.1 g/cm3(Predicted)
storage temp. -20°C Freezer, Under Inert Atmosphere
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 2.62±0.50(Predicted)
color White

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07,GHS08
Signal word  Danger
Hazard statements  H317-H360
Precautionary statements  P501-P261-P272-P201-P202-P280-P302+P352-P308+P313-P362+P364-P333+P313-P405
HS Code  2941906000

Cefpiramide acid Chemical Properties,Uses,Production

Uses

Antibacterial.

Definition

ChEBI: A third-generation cephalosporin antibiotic with [(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl and (R)-2-{[(4-hydroxy-6-methylpyridin-3-yl)carbonyl]amino}-2-(4-hydroxyphenyl)acetamido groups at positions 3 and 7, respectiv ly, of the cephem skeleton. It has a broad spectrum of antibacterial activity.

Antimicrobial activity

A semisynthetic parenteral cephalosporin. It exhibits a broad range of activity, which includes Ps. aeruginosa, though the overall activity is rather modest. It is moderately stable to most β-lactamases but less so than ceftazidime or cefpirome.
In volunteers given 0.5 or 1 g by intravenous bolus, the mean plasma concentration shortly after injection was around 150 or 300 mg/L, respectively. There was no accumulation when the same doses were repeated every 12 h for 11 doses. It is highly bound to plasma protein (c. 95%). The mean plasma half-life is around 5 h. Less than one-quarter of the dose appears in the urine over 24 h; the rest is excreted in bile and high concentrations are found in feces. Renal impairment has little effect on elimination in patients with normal liver function.
Diarrhea may be associated with marked suppression of gut flora resulting from biliary excretion of the drug. The molecule includes a C-3 methylthiotetrazole side chain and side effects associated with that substituent are to be expected.
It is available in Japan.

Cefpiramide acid Preparation Products And Raw materials

Raw materials

4-Methylmorpholine Phenyl glycine Potassium bicarbonate Sodium chloride CARBONYL SULFIDE
1,4-Dioxane 2,6-Lutidine Isobutyl chloroformate Magnesium sulfate
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Preparation Products

Cefpiramide acid Suppliers

Global( 154)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
Henan Tianfu Chemical Co.,Ltd. +86-0371-55170693 +86-19937530512 China 21669 55 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
ANHUI WITOP BIOTECH CO., LTD +8615255079626 China 23556 58 Inquiry
Shaanxi Dideu Medichem Co. Ltd +86-029-89586680 +86-18192503167 China 9030 58 Inquiry
AFINE CHEMICALS LIMITED +86-0571-85134551 China 15395 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Pharma Affiliates 58
Henan Tianfu Chemical Co.,Ltd. 55
CONIER CHEM AND PHARMA LIMITED 58
career henan chemical co 58
TargetMol Chemicals Inc. 58
ANHUI WITOP BIOTECH CO., LTD 58
Shaanxi Dideu Medichem Co. Ltd 58
AFINE CHEMICALS LIMITED 58

70797-11-4(Cefpiramide acid)Related Search:

Phenylhydrazine Stearic acid Citric acid PYRAZOPHOS Cefpiramide sodium
Glycine Folic acid ALTRENOGEST CHLOROPHOSPHONAZO III 4-Dimethylaminopyridine
2-Hydroxypyridine Ethyl 2-(Chlorosulfonyl)acetate PHENYL VALERATE 2-Aminopyridine 3-Aminopyridine
Cefapirin sodium Cefpirome Ascoric Acid
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(6R,7R)-7-[(2R)-2-(4-hydroxyphenyl)-2-[(6-Methyl-4-oxo-1,4-dihydropyridin-3-yl)forMaMido]acetaMido]-3-{[(1-Methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]Methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 7-aMino-3-(1-Methyl-1-pyrroleane oniuM acids)Methyl-2-oxacepheMs-2-Carboxylic Acid Hydrochloride Suncefal：Sepatren 7-[2-[(4-hydroxy-6-methylpyridine-3-carbonyl)-amino]-2-(4-hydroxy phenyl)-acetylamin]-3-(1-methyl-1h-tetrazole-5-thiomethyl)-8-keto-5-thiox-1-azole[4.2.0]octadiene-2-carboxylic acid CEFPIRAMIDE cefpiramide acid 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-[[(4-hydroxy-6-methyl-3-pyridinyl)carbonyl]amino](4-hydroxyphenyl)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, (6R,7R)- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[[[(4-hydroxy-6-methyl-3-pyridinyl)carbonyl]amino](4-hydroxyphenyl)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, [6R-[6α,7β(R*)]]- Cefpiramide (300 mg) sodium 7-[[2-(4-hydroxyphenyl)-2-[[(6-methyl-4-oxo-1H-pyridin-3-yl)-oxomethyl]amino]-1-oxoethyl]amino]-3-[[(1-methyl-5-tetrazolyl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Cefpiramido Cefpiramidum 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-2-[[(4-hydroxy-6-methyl-3-pyridinyl)carbonyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, (6R,7R)- Cefpiramide acid USP/EP/BP Cefpiramide (1098118) (6R,7R)-7-((R)-2-(4-hydroxy-6-methylnicotinamido)-2-(4-hydroxyphenyl)acetamido)-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Cefpiramidum|||Cefpiramido 70797-11-4 156-1-43 99-0-9 C25H24N8O7S2 Pharmaceutical intermediate Miscellaneous