Dydrogesterone
- CAS No.
- 152-62-5
- Chemical Name:
- Dydrogesterone
- Synonyms
- (9beta,10alpha)-pregna-4,6-diene-3,20-dione;gynorest;duphaston;Dydrogesteron;DH 33;prodel;Duvaro;Retron;terolut;retrone
- CBNumber:
- CB5275115
- Molecular Formula:
- C21H28O2
- Molecular Weight:
- 312.45
- MOL File:
- 152-62-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/13 12:20:35
| Melting point | 168-173°C |
|---|---|
| alpha | D25 -484.5° (chloroform) |
| Boiling point | 392.36°C (rough estimate) |
| Density | 1.0697 (rough estimate) |
| refractive index | 1.4900 (estimate) |
| storage temp. | 2-8°C |
| solubility | Practically insoluble in water, soluble in acetone, sparingly soluble in ethanol (96 per cent). |
| form | Solid |
| color | White to Light Yellow |
| InChI | InChI=1/C21H28O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4-5,12,16-19H,6-11H2,1-3H3/t16-,17+,18-,19+,20+,21+/s3 |
| InChIKey | JGMOKGBVKVMRFX-HQZYFCCVSA-N |
| SMILES | C[C@@]12CCC(=O)C=C1C=C[C@@]1([H])[C@]3([H])CC[C@H](C(=O)C)[C@@]3(C)CC[C@@]21[H] |&1:1,10,12,16,20,24,r| |
| CAS DataBase Reference | 152-62-5(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H372-H410 |
| Precautionary statements | P260-P264-P270-P314-P501-P273-P391-P501 |
| RIDADR | UN 3077 9 / PGIII |
| Toxicity | LD50 oral in rat: > 4600mg/kg |
Dydrogesterone Chemical Properties,Uses,Production
Description
Dydrogesterone is a synthetic progestogen that has no estrogenic, androgenic, glucocorticoid, or anabolic effects, although it is an agonist of progesterone receptors (EC50 = 12.3 nM) and an antagonist of androgen, mineralocorticoid, and glucocorticoid receptors (IC50s = 28.6, 82.7, and 363 nM, respectively). Dydrogesterone protects against sound stress-induced abortion in mice when administered at a dose of 1.25 mg per animal prior to the stressor on day five of pregnancy. Formulations containing dydrogesterone have been used in hormone replacement therapy, in the treatment of menstrual disorders, and to prevent miscarriage.
Chemical Properties
Light Yellow Solid
Uses
A synthetic progestin largely used in hormone therapy, on the central nervous system by studying two markers of the neuroendocrine function: the neurosteroid allopregnanolone and the opioid .beta.-endorphin. Progestogen.
Application
Dydrogesterone is a synthetic progestin. Dydrogesterone alone or in combination with estrogen to endothelial cells results in neutral effects on NO synthesis and on the activity and expression of eNOS.
Side effects
Depression, feeling dizzy, vomiting, liver problems (jaundice (yellow eyes), weakness, stomach pain, generalized discomfort), allergic skin reactions (rashes, itching, redness), weight gain.
Synthesis
Dissolving progesterone, and carrying out photochemical reaction to obtain 9 beta, 10 alpha-pregn-4-ene-3, 20-diketone; mixing the 9 beta, 10 alpha-pregn-4-ene-3, 20-dione, an organic solvent and a benzoquinone oxidant, and carrying out dehydrogenation oxidation reaction to obtain dydrogesterone.
Dydrogesterone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SIMSON PHARMA LIMITED | +91-8291074273 | Shanghai, India | 228 | 58 | Inquiry |
| La Chandra Pharmalab Pvt. Ltd. | +91-9099028738 +91-9099028738 | Gujarat, India | 8 | 58 | Inquiry |
| Horster Biotek Pvt Ltd | +91-7359657360 +91-9898127219 | Gujarat, India | 58 | 58 | Inquiry |
| Prachem Laboratories | +91-7948993109 +91-7383072020 | Gujarat, India | 44 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Emcure Pharmaceuticals Pvt Ltd | +91-2035070000 +91-2040240000 | Maharashtra, India | 5 | 58 | Inquiry |
| AKASH PHARMA EXPORTS | +91-9388123451 +91-9846039283 | Kerela, India | 470 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
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