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Iopamidol

Iopamidol Structure
CAS No.
60166-93-0
Chemical Name:
Iopamidol
Synonyms
isovue;niopam;b-15000;lamide);sq13396;iopamiro;Jopamiro;Solutras;iopamido;iopamiron
CBNumber:
CB5384796
Molecular Formula:
C17H22I3N3O8
Molecular Weight:
777.09
MOL File:
60166-93-0.mol
Modify Date:
2024/7/2 8:55:11
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Iopamidol Properties

Melting point >3200C (dec)
alpha D20 -2.01° (c = 10 in water)
Boiling point 740.14°C (rough estimate)
Density 2.0203 (estimate)
storage temp. Keep in dark place,Sealed in dry,2-8°C
solubility Freely soluble in water, very slightly soluble in methanol, practically insoluble in ethanol (96 per cent) and in methylene chloride
pka pKa (25°) 10.70
form Solid
color White to off-white
Water Solubility 473.7g/L(25 ºC)
CAS DataBase Reference 60166-93-0(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338
HS Code  2924296000
Toxicity LD50 in mice, rats, rabbits, dogs (g/kg): 44.5, 28.2, 19.6, 34.7 i.v. (Felder); LD50 in mice (mg iodine/kg body wt): 21,800 i.v.; 20,000 i.p.; 1500 intracerebral (Felder, Pitre).

Iopamidol price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) PHR1985 Iopamidol Pharmaceutical Secondary Standard; Certified Reference Material 60166-93-0 500MG ₹22840.75 2022-06-14 Buy
Product number Packaging Price Buy
PHR1985 500MG ₹22840.75 Buy

Iopamidol Chemical Properties,Uses,Production

Chemical Properties

White Crystalline Powder

Uses

Iopamidol is an organic iodine compound and used as a nonionic radiocontrast medium. Diagnostic aid (radiopaque medium). Iopamidol blocks x-rays as they pass through the body, thereby allowing body structures not containing iodine to be visualized. The degree of opacity produced by iopamidol is directly proportional to the total amount of the iodinated contrast agent in the path of the x-rays. The visualization of body structures is dependent upon the distribution and elimination of iopamidol. (NCI05)

Definition

ChEBI: Iopamidol is a benzenedicarboxamide compound having N-substituted carbamoyl groups at the 1- and 3-positions, iodo substituents at the 2-, 4- and 6-positions and a (2S)-2-hydroxypropanamido group at the 5-position. It has a role as a radioopaque medium, an environmental contaminant and a xenobiotic. It is a benzenedicarboxamide, an organoiodine compound and a pentol.

General Description

Iopamidol is a low-osmolar, nonionicmonomer with 49% organically bound iodine. It is indicatedfor use in angiography, excretory urography, andnumerous CT procedures.

Side effects

Arm, back, or jaw pain; blurred vision; chest pain or discomfort; chest tightness or heaviness; confusion; dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position; fast or irregular heartbeat; feeling of warmth; hives; lightheadedness, dizziness, or fainting; nausea; redness of the face, neck, arms, and occasionally, upper chest; slow or irregular heartbeat; sudden sweating; trouble breathing; unusual tiredness or weakness

Toxicology

Serious skin reactions , including Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS), and acute generalized exanthematous pustulosis can occur with this medicine. Results from in vitro HEK293T cell-based assays indicate that iopamidol affects mitochondrial function Treatment with iopamidol induces ATP depletion, reduces the mitochondrial membrane potential, and elevates mitochondrial superoxide and reactive oxygen species accumulation.

Mode of action

Iopamidol is a Radiographic Contrast Agent. The mechanism of action of iopamidol is as a X-Ray Contrast Activity.

Iopamidol Preparation Products And Raw materials

Raw materials

Thionyl chloride 1,3-Propanediol, 2-(2,2-diethoxyethyl)-,monoacetate,(R)- 2-Amino-1,3,4-thiadiazole 5-Amino-2,4,6-triiodoisophthalic acid 5-amino-N1,N3-bis(1,3-dihydroxypropan-2-yl)isophthalamide
5-Amino-N,N'-bis[2-hydroxy-1-(hydroxymethyl) ethyl]-2,4,6-triiodobenzene-1,3-dicarboxamide (S)-5-[2-(acetyloxy)propanamido]-2,4,6-triiodo-1,3-di(chloroformyl)benzene 2-Amino-1,3-propanediol 5-Nitroisophthalic acid
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Preparation Products

Iopamidol Suppliers

Global( 186)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CNS CHEMICALS +91-9381957258 +91-9381957258 Telangana, India 354 58 Inquiry
Divis Laboratories Ltd +91-4066966413 +91-4066966413 Hyderabad, India 34 58 Inquiry
JR Corporation +91-9099076719 +91-7096568000 Gujarat, India 14 58 Inquiry
Humble Healthcare Limited +91-9720093000 +91-8006400378 Uttar Pradesh, India 141 58 Inquiry
cheminorlifesciences +91-9949586633 +91-9848182318 Telangana, India 3 58 Inquiry
Blue Jet Healthcare Ltd +91-02222071691 +91-9082861262 Mumbai, India 86 58 Inquiry
Medilink Pharmachem +91 (79) 3007-0133 New Delhi, India 424 50 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Supplier Advantage
CNS CHEMICALS 58
Divis Laboratories Ltd 58
JR Corporation 58
Humble Healthcare Limited 58
cheminorlifesciences 58
Blue Jet Healthcare Ltd 58
Medilink Pharmachem 50
Pharmaffiliates Analytics and Synthetics P. Ltd 58
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58

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Iopamidol Spectrum

Iopamidol(60166-93-0)1HNMR

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N,N'-Bis(2-hydroxy-1-(hydroxymethyl)ethyl)-5-((2-hydroxy-1-oxopropyl)amino)-2,4,6-triiodo-1,3-Benzenedicarboxamide N,N'-BIS(1,3-DIHYDROXYPROPAN-2-YL)-5-(2-HYDROXYPROPANOYLAMINO)-2,4,6-TRIIODO-BENZENE-1,3-DICARBOXAMIDE 1,3-benzenedicarboxamide,n,n’-bis(2-hydroxy-1-(hydroxymethyl)ethyl)-5-((2-hydr -2-propylamide) 6-triiodo-(s)-oxy-1-oxopropyl)amino)- b-15000 hthalamide iopamiro iopamiron isovue isovue-370 jopamiron200 l-(+)-n,n’-bis(2-hydroxy-1-hydroxymethylethyl)-2,4,6-triiodo-5-lactamideisop l-5alpha-hydroxypropionylamino-2,4,6-triiodoisophthalicaciddi(1,3-dihydroxy l-5alpha-idrossipropionilamino-2,4,6-triiodoisoftal-di(1,3-diidrossi-2-propi lamide) niopam niopam300 solutrast solutrast370 sq13396 Iopamidol (S)-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiodoisophthaldiamide Iomapidol Jopamiro N,NBis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[[(2S)-2-hydroxy-1-oxopropyl]amino]-2,4,6-triiodo-1,3-benzenedicarboxamide Solutras 1,3-Benzenedicarboxamide, N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiodo-, (S)- 1,3-Benzenedicarboxamide, N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[[(2S)-2-hydroxy-1-oxopropyl]amino]-2,4,6-triiodo- Iopamidol 300 Iopamiro 370 Iopamiron 300 Iopamiron 370 Isovue 300 (S)-N,N'-Bis(1,3-dihydroxypropan-2-yl)-5-[[(2S)-2-hydroxypropanoyl]amino]-2,4,6-triiodobenzene-1,3-dicarboxamide Iopamidol (200 mg) (S)-N,N′-Bis[2-hydroxy-1-(hydroxymethyl)ethyl]-2,4,6-triiodo-5-lactamidoisophthalamide Iopamidol ( for Contrast Agents ) IOPAMIRO;ISOVUE;IOPAMIRON;NIOPAM (2S)-Iopamidol, isomer mixture 1,3-Benzenedicarboxamide, N1,N3-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[[(2S)-2-hydroxy-1-oxopropyl]amino]-2,4,6-triiodo- (S)-N1,N3-bis(1,3-dihydroxypropan-2-yl)-5-(2-hydroxypropanamido)-2,4,6-triiodoisophthalamide Iopamidol USP/EP/BP iopamido (S)-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy... Iopamidol (1344702) Iopomidol Iopamidol 60166-93-0 77709 Diagnostic Intermediates & Fine Chemicals Pharmaceuticals