Iopamidol
![Iopamidol Structure](CAS/GIF/60166-93-0.gif)
- CAS No.
- 60166-93-0
- Chemical Name:
- Iopamidol
- Synonyms
- isovue;niopam;b-15000;lamide);sq13396;iopamiro;Jopamiro;Solutras;iopamido;iopamiron
- CBNumber:
- CB5384796
- Molecular Formula:
- C17H22I3N3O8
- Molecular Weight:
- 777.09
- MOL File:
- 60166-93-0.mol
- Modify Date:
- 2024/7/2 8:55:11
Melting point | >3200C (dec) |
---|---|
alpha | D20 -2.01° (c = 10 in water) |
Boiling point | 740.14°C (rough estimate) |
Density | 2.0203 (estimate) |
storage temp. | Keep in dark place,Sealed in dry,2-8°C |
solubility | Freely soluble in water, very slightly soluble in methanol, practically insoluble in ethanol (96 per cent) and in methylene chloride |
pka | pKa (25°) 10.70 |
form | Solid |
color | White to off-white |
Water Solubility | 473.7g/L(25 ºC) |
CAS DataBase Reference | 60166-93-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
HS Code | 2924296000 |
Toxicity | LD50 in mice, rats, rabbits, dogs (g/kg): 44.5, 28.2, 19.6, 34.7 i.v. (Felder); LD50 in mice (mg iodine/kg body wt): 21,800 i.v.; 20,000 i.p.; 1500 intracerebral (Felder, Pitre). |
Iopamidol Chemical Properties,Uses,Production
Chemical Properties
White Crystalline Powder
Uses
Iopamidol is an organic iodine compound and used as a nonionic radiocontrast medium. Diagnostic aid (radiopaque medium). Iopamidol blocks x-rays as they pass through the body, thereby allowing body structures not containing iodine to be visualized. The degree of opacity produced by iopamidol is directly proportional to the total amount of the iodinated contrast agent in the path of the x-rays. The visualization of body structures is dependent upon the distribution and elimination of iopamidol. (NCI05)
Definition
ChEBI: Iopamidol is a benzenedicarboxamide compound having N-substituted carbamoyl groups at the 1- and 3-positions, iodo substituents at the 2-, 4- and 6-positions and a (2S)-2-hydroxypropanamido group at the 5-position. It has a role as a radioopaque medium, an environmental contaminant and a xenobiotic. It is a benzenedicarboxamide, an organoiodine compound and a pentol.
General Description
Iopamidol is a low-osmolar, nonionicmonomer with 49% organically bound iodine. It is indicatedfor use in angiography, excretory urography, andnumerous CT procedures.
Side effects
Arm, back, or jaw pain; blurred vision; chest pain or discomfort; chest tightness or heaviness; confusion; dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position; fast or irregular heartbeat; feeling of warmth; hives; lightheadedness, dizziness, or fainting; nausea; redness of the face, neck, arms, and occasionally, upper chest; slow or irregular heartbeat; sudden sweating; trouble breathing; unusual tiredness or weakness
Toxicology
Serious skin reactions , including Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS), and acute generalized exanthematous pustulosis can occur with this medicine. Results from in vitro HEK293T cell-based assays indicate that iopamidol affects mitochondrial function Treatment with iopamidol induces ATP depletion, reduces the mitochondrial membrane potential, and elevates mitochondrial superoxide and reactive oxygen species accumulation.
Mode of action
Iopamidol is a Radiographic Contrast Agent. The mechanism of action of iopamidol is as a X-Ray Contrast Activity.
Iopamidol Preparation Products And Raw materials
Raw materials
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Supplier | Tel | Country | ProdList | Advantage | Inquiry |
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CNS CHEMICALS | +91-9381957258 +91-9381957258 | Telangana, India | 354 | 58 | Inquiry |
Divis Laboratories Ltd | +91-4066966413 +91-4066966413 | Hyderabad, India | 34 | 58 | Inquiry |
JR Corporation | +91-9099076719 +91-7096568000 | Gujarat, India | 14 | 58 | Inquiry |
Humble Healthcare Limited | +91-9720093000 +91-8006400378 | Uttar Pradesh, India | 141 | 58 | Inquiry |
cheminorlifesciences | +91-9949586633 +91-9848182318 | Telangana, India | 3 | 58 | Inquiry |
Blue Jet Healthcare Ltd | +91-02222071691 +91-9082861262 | Mumbai, India | 86 | 58 | Inquiry |
Medilink Pharmachem | +91 (79) 3007-0133 | New Delhi, India | 424 | 50 | Inquiry |
Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
Supplier | Advantage |
---|---|
CNS CHEMICALS | 58 |
Divis Laboratories Ltd | 58 |
JR Corporation | 58 |
Humble Healthcare Limited | 58 |
cheminorlifesciences | 58 |
Blue Jet Healthcare Ltd | 58 |
Medilink Pharmachem | 50 |
Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |
CLEARSYNTH LABS LTD. | 58 |
A.J Chemicals | 58 |
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