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ChemicalBook > Product Catalog >Biochemical Engineering >Amino Acids and Derivatives >Amino alcohol derivative >2-Amino-1,3-propanediol

2-Amino-1,3-propanediol

2-Amino-1,3-propanediol Structure
CAS No.
534-03-2
Chemical Name:
2-Amino-1,3-propanediol
Synonyms
2-AMINOPROPANE-1,3-DIOL;SERINOL;DL-SERINOL;Serinol 98%;S8002Dl-Serinol;2-Aminoglycerol;2-Amino-1,3-propaned;Silk ammonia alcohol;2-Aminopropan-1,3-diol;2-AMINO-1,3-PROPANDIOL
CBNumber:
CB1738085
Molecular Formula:
C3H9NO2
Molecular Weight:
91.11
MOL File:
534-03-2.mol
MSDS File:
SDS
Modify Date:
2024/7/24 13:33:21
Request For Quotation

2-Amino-1,3-propanediol Properties

Melting point 52-55 °C (lit.)
Boiling point 277 °C (lit.)
Density 1.1278 (rough estimate)
vapor pressure 0.01Pa at 25℃
refractive index 1.4698 (estimate)
Flash point >230 °F
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility DMSO (Soluble, Sonicated), Methanol (Slightly, Sonicated), Water (Slightly)
pka 12.24±0.10(Predicted)
form Adhering Crystalline Powder
color White to off-white
Water Solubility Soluble in water and alcohol.
Sensitive Hygroscopic
BRN 635683
Stability Hygroscopic
InChIKey KJJPLEZQSCZCKE-UHFFFAOYSA-N
LogP -1.82 at 20℃
CAS DataBase Reference 534-03-2(CAS DataBase Reference)
NIST Chemistry Reference 2-Amino-1,3-propanediol(534-03-2)
EPA Substance Registry System 1,3-Propanediol, 2-amino- (534-03-2)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS05
Signal word  Danger
Hazard statements  H314
Precautionary statements  P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363
Hazard Codes  C,Xi
Risk Statements  34
Safety Statements  26-27-28-36/37/39-45
RIDADR  UN 3263 8/PG 2
WGK Germany  1
F  3-10-34
Hazard Note  Corrosive
TSCA  Yes
HazardClass  8
PackingGroup  III
HS Code  29221990
NFPA 704
1
3 1

2-Amino-1,3-propanediol price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 357898 Serinol 98% 534-03-2 1G ₹1634.58 2022-06-14 Buy
Sigma-Aldrich(India) 357898 Serinol 98% 534-03-2 5G ₹3756.28 2022-06-14 Buy
TCI Chemicals (India) A1252 2-Amino-1,3-propanediol min. 98.0 % 534-03-2 5G ₹2900 2022-05-26 Buy
TCI Chemicals (India) A1252 2-Amino-1,3-propanediol min. 98.0 % 534-03-2 25G ₹9000 2022-05-26 Buy
Product number Packaging Price Buy
357898 1G ₹1634.58 Buy
357898 5G ₹3756.28 Buy
A1252 5G ₹2900 Buy
A1252 25G ₹9000 Buy

2-Amino-1,3-propanediol Chemical Properties,Uses,Production

Description

2-Amino-1,3-propanediol (2-APD, also known as serinol) is a high-value-added chemical that is used as a building block for the synthesis of a variety of compounds, including drugs to treat type 2 diabetes mellitus, the antibiotic chloramphenicol, immune multiple sclerosis, and a new generation of nonionic X-ray contrast agents.

Chemical Properties

white to off-white adhering crystalline powder

Uses

2-Amino-1,3-propanediol is used as an intermediate in several chemical applications and also useful for serinol and some of its derivatives.

Preparation

Add 20% 2-nitro-1,3-propanediol methanol solution (1250 g) to 5% palladium/carbon 3.5 g. Hydrogen (70 L, pressure 3MPa) was continuously introduced and reacted at 75°C for 5 hours to obtain serine alcohol solution. The serine alcohol solution is pumped into a high vacuum distillation vessel, vacuumed to 40 pa, and methanol is distilled for reuse. Yield = 97.2%.2-Amino-1,3-propanediol

Biosynthesis

Currently, the manufacture of 2-Amino-1,3-propanediol (2-APD) predominantly relies on chemical processes by utilizing fossil fuel-derived and highly explosive raw materials. In addition to chemical synthesis, its synthesis can also rely on biosynthesis. Luo et al. established an artificial biosynthetic pathway for converting glucose to 2-APD in a metabolically engineered Escherichia coli. This artificial pathway employs an engineered heterogeneous aminotransferase RtxA for diverting dihydroxyacetone phosphate (DHAP) to generate 2-APD phosphate and an endogenous phosphatase for converting it into the target product 2-APD. 2-APD-P is 2-amino-1,3-propanediol phosphate[1].2-Amino-1,3-propanediol

Origin

In the 1970s, 2-Amino-1,3-propanediol (2-APD) was first reported to be a molecular building block of the natural products rhizobitoxine and dihydrorhizobitoxine produced by the legume symbiont Rhizobium japonicum[1].

General Description

Serinol activates toxin production in the attenuated cultures of Helminthosporium sacchari. Preparation of polyesters derived from serinol is reported.

References

[1] Luo Y, et al. An Artificial Biosynthetic Pathway for 2?Amino-1,3-Propanediol Production Using Metabolically Engineered Escherichia coli. ACS Synthetic Biology, 2019; 8: 548–556.

2-Amino-1,3-propanediol Preparation Products And Raw materials

Raw materials

1,3-DIOXANE 2-AMINO-1,3-PROPANEDIOL OXALATE 1,3-Dioxan-5-amine,2-phenyl-(9CI) 1,3-Propanediol, 2,2'-iminobis- L-Serine methyl ester hydrochloride
DIMETHYL 2-AMINOMALONATE, TECH 2-Nitro-1,3-propanediol 2,5-Dihydroxy-1,4-dioxane-2,5-dimethanol
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Preparation Products

L-Serine Iopamidol 2-(DiMethylaMino)propane-1,3-diol

2-Amino-1,3-propanediol Suppliers

Global( 544)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Seema Finechem Industry LLP +91-8451840941 +91-8451840941 NaviMumbai, India 43 58 Inquiry
Vardhaman P Golechha 9704422000 Telangana, India 294 58 Inquiry
Saasta Life Sciences +91-9182206108 +91-9704665959 Hyderabad, India 32 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Seema Finechem Industry LLP 08048372760Ext 117 Mumbai, India 67 58 Inquiry
Spectrochem Private Limited 08048372608Ext 246 Maharashtra, India 1056 58 Inquiry
S. N. Chemicals 91-9309242010 Rajasthan, India 16 58 Inquiry
Biopharmacule Speciality Chemicals P Ltd (India) +91 40 6462 1866 Hyderabad, India 526 58 Inquiry
OCEAN TRADING CORPORATION +91(22) 24921669 New Delhi, India 6211 58 Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6778 58 Inquiry
Supplier Advantage
Seema Finechem Industry LLP 58
Vardhaman P Golechha 58
Saasta Life Sciences 58
A.J Chemicals 58
Seema Finechem Industry LLP 58
Spectrochem Private Limited 58
S. N. Chemicals 58
Biopharmacule Speciality Chemicals P Ltd (India) 58
OCEAN TRADING CORPORATION 58
TCI Chemicals (India) Pvt. Ltd. 58

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1,3-Propanediol, 2-amino- DL-SERINOL 2-AMINO-1,3-PROPANDIOL 2-AMINO-1,3-PROPANEDIOL 2-Aminopropan-1,3-propanediol 2-Amino-1,3-dihydroxypropane Serinol[2-Amino-1,3-Propandiol] S8002Dl-Serinol 2-Amino-1,3-Propanediol(Serinol) 2-Amino-1,3-propanediol 99% 2-Aminopropan-1,3-diol 2-AMINO-1,3-PROPANDIOL (SERINOL) 1,3-Dihydroxy-2-propylamine 1,3-Dihydroxyisopropylamine 2-Aminoglycerol 2-Amino-1,3-propanediol,98% 2-Amino-1,3-propanediol ,99% 2-Amino-1,3-propaned 2-Aminopropane-1,3-diol 99% 2-aMlno-1,3-propanedio Serinol 98% Serinol, 2-Amino-1,3-dihydroxypropane 2-Amino 1, 3-Propanediol /Serinol (CAS NO: 534-03-2) (Diacetoxyiodo)benzene / Iodobenzene Diacetate ( CAS No : 3240-34-4) 2-Amino-1,3-propanediol (APD) 2-Amino-1,3-propanediol > 2-Amino-1,3-propanediol USP/EP/BP SERINOL 2-AMINOPROPANE-1,3-DIOL Silk ammonia alcohol Serinol/2-amino-1,3-propanediol 2-Amino-1,3-Prpanediol 534-03-2 HOCH2CHNH2CH2OH Building Blocks Amino Alcohols AMINE Organic Building Blocks Oxygen Compounds API intermediates Alcohols and Derivatives Pharmaceutical Intermediates Intermediate bc0001 534-03-2 Amino Acid