4-Hydroxyindole
- CAS No.
- 2380-94-1
- Chemical Name:
- 4-Hydroxyindole
- Synonyms
- 1H-INDOL-4-OL;4-Hdroxyindole;4-INDOLOL;INDOL-4-OL;1H-INDOLE-4-OL;4-HydroxyindoL;4-HYDROXYINDOLE;4-Hydroxxyindole;4-Hydroxylndole;4-Hydroxyindole>
- CBNumber:
- CB5663260
- Molecular Formula:
- C8H7NO
- Molecular Weight:
- 133.15
- MOL File:
- 2380-94-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/19 22:55:17
| Melting point | 97-99 °C(lit.) |
|---|---|
| Boiling point | 245.66°C (rough estimate) |
| Density | 1.1475 (rough estimate) |
| vapor pressure | 0.019Pa at 25℃ |
| refractive index | 1.5260 (estimate) |
| storage temp. | 0-6°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 9.89±0.40(Predicted) |
| color | Dark Yellow to Green-Grey |
| Water Solubility | slightly soluble |
| Sensitive | Air Sensitive |
| BRN | 114905 |
| InChIKey | NLMQHXUGJIAKTH-UHFFFAOYSA-N |
| LogP | 1.57 at 25℃ |
| CAS DataBase Reference | 2380-94-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | IRRITANT, KEEP COLD | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
4-Hydroxyindole price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 219878 | 4-Hydroxyindole 99% | 2380-94-1 | 1G | ₹11636.88 | 2022-06-14 | Buy |
| ALFA India | ALF-L14352-ME | 4-Hydroxyindole, 98% | 2380-94-1 | 500mg | ₹2104 | 2022-05-26 | Buy |
| ALFA India | ALF-L14352-MC | 4-Hydroxyindole, 98% | 2380-94-1 | 100mg | ₹1416 | 2022-05-26 | Buy |
| ALFA India | ALF-L14352-14 | 4-Hydroxyindole, 98% | 2380-94-1 | 25g | ₹36449 | 2022-05-26 | Buy |
| ALFA India | ALF-L14352-06 | 4-Hydroxyindole, 98% | 2380-94-1 | 5g | ₹10702 | 2022-05-26 | Buy |
4-Hydroxyindole Chemical Properties,Uses,Production
Chemical Properties
Off-White Cyrstalline Solid
Uses
4-Hydroxyindole is a Pindolol (P468000) impurity, which is a mixed adrenergic blocker and serotonin 5HT1A-receptor antagonist.
Definition
ChEBI: 4-hydroxyindole is a member of the class of hydroxyindoles that is 1H-indole substituted by a hydroxy group at position 4. It is a member of phenols and a member of hydroxyindoles.
Application
4-Hydroxyindole as simple indoles is the important raw material or intermediate in the synthesis of pharmaceutical products and industrial polymers. It effectively inhibits Abeta peptide-induced amyloid fibril formation and prevent cell death induced by the peptide in culture. It is used for the synthesis of anti-inflammatory angular pyrrolocoumarins.
Preparation
Synthesis of 4-hydroxyindole: Using resorcinol as raw material, 4-oxotetrahydrocoumarone carboxylic acid is prepared by isomerization, catalytic hydrogenation, and cyclization with ethyl bromopyruvate. It was added to methanol solution saturated with ammonia, and the reaction was heated in an autoclave to generate 4-oxotetrahydroindole. Finally, 4-hydroxyindole is obtained by dehydrogenation and isomerization.
General Description
Glucouridination of 4-hydroxyindole by human uridine 5′-diphospho-glucuronosyltransferase has been repotrted.
4-Hydroxyindole Preparation Products And Raw materials
Raw materials
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Related articles
- What is 4-Hydroxyindole?
- 4-Hydroxyindole (1H-INDOL-4-OL; 1H-INDOLE-4-OL; 4-HYDROXY-1H-INDOLE; 4-INDOLOL; 4-HYDROXYINDOLE; INDOL-4-OL; 4-Hydroxy Indole ....
- Feb 19，2020
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