Pindolol
- CAS No.
- 13523-86-9
- Chemical Name:
- Pindolol
- Synonyms
- lb46;LB-46;Visken;Vasken;dl-lb46;Decreten;Pinbetol;Pynastin;PINDOLOL;(+-)-lb46
- CBNumber:
- CB3105373
- Molecular Formula:
- C14H20N2O2
- Molecular Weight:
- 248.32
- MOL File:
- 13523-86-9.mol
- Modify Date:
- 2023/6/8 9:02:50
| Melting point | 167-171 °C(lit.) |
|---|---|
| Boiling point | 391.39°C (rough estimate) |
| Density | 1.0606 (rough estimate) |
| refractive index | 1.5110 (estimate) |
| storage temp. | 2-8°C |
| solubility | 0.1 M NaOH: 0.2 mg/mL |
| form | powder |
| pka | pKa 9.26 (Uncertain) |
| color | white to off-white |
| Water Solubility | 33mg/L(22.5 ºC) |
| Merck | 13,7525 |
| CAS DataBase Reference | 13523-86-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Pindolol(13523-86-9) |
| EPA Substance Registry System | 2-Propanol, 1-(1H-indol-4-yloxy)-3-[(1-methylethyl)amino]- (13523-86-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P301+P312+P330-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | 3249 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UB6660000 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2933995300 | |||||||||
| Toxicity | LD50 oral in rabbit: 650mg/kg | |||||||||
| NFPA 704 |
|
Pindolol price More Price(2)
Pindolol Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
Pindolol, like nadolol, is a nonselective β-adrenoblocker. It possesses antianginal, antihypotensive, and antiarrythmic action. It is used for arterial hypertension, angina stress (preventing attacks), supraventricular tachycardia, tachsystolic form of atrial fibrillation, and superventricular extrasystole.
Definition
ChEBI: A member of the class of indols which is the 2-hydroxy-3-(isopropylamino)propyl ether derivative of 1H-indol-4-ol.
Biological Activity
5-HT 1A/1B ? receptor antagonist, with roughly equal affinity for each subtype. A partial agonist at mouse and human β 3 -adrenoceptors.
Metabolic pathway
Several metabolites of pindolol formed in vitro are detected after a 24 h incubation of human hepatocytes in both pure culture and co-culture by adding rat liver epithelial cells. The hepatocytes are able to oxidize the isopropyl amine moiety and the pyrrole ring of the indole moiety and conjugate pindolol as sulfates and glucuronides.
Metabolism
Pindolol (Visken) is extensively absorbed from the gastrointestinal tract. First-pass metabolism is estimated at about 15%, and its plasma half-life is on the order of 3 to 4 hours.The binding of pindolol to plasma proteins is approximately 50%.The metabolic fate of pindolol is not completely understood, although 50% of an administered dose is recovered, primarily in the urine, as unchanged drug.
Pindolol Preparation Products And Raw materials
Raw materials
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| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Centaur Pharmaceuticals Pvt Ltd | +912266499100 | Mumbai, India | 33 | 58 | Inquiry |
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| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| CENTAUR PHARMACEUTICALS PRIVATE LTD | +91 22 – 66499100 | New Delhi, India | 17 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
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| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | China | 9327 | 58 | Inquiry |
| CD Chemical Group Limited | +8615986615575 | China | 20356 | 58 | Inquiry |
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