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azalanstat

azalanstat Structure
CAS No.
143393-27-5
Chemical Name:
azalanstat
Synonyms
Rs-21607;Rs 21607;azalanstat;Unii-2nl79ni1ws;Azalanstat [inn];Azalanstat mesylate;Benzenamine, 4-[[[(2S,4S)-2-[2-(4-chlorophenyl)ethyl]-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl]thio]-;Benzenamine, 4-(((2-(2-(4-chlorophenyl)ethyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methyl)thio)-, (2S-cis)-
CBNumber:
CB61377064
Molecular Formula:
C22H24ClN3O2S
Molecular Weight:
429.96
MOL File:
143393-27-5.mol
Modify Date:
2023/7/14 17:33:45
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azalanstat Properties

Melting point 151 °C
Boiling point 647.7±40.0 °C(Predicted)
Density 1.31±0.1 g/cm3(Predicted)
pka 6.88±0.12(Predicted)

azalanstat Chemical Properties,Uses,Production

Uses

Hypolipidemic.

Enzyme inhibitor

This imidazole-containing agent (FW = 429.96 g/mol), also known as RS- 21607, inhibits both inducible heme oxygenase-1 and constitutive heme oxygenase-2 (rat IC50 = 5.3 and 24.5 μM, respectively). The m aminophenyl analogue is a slightly stronger inhibitor of heme oxygenase-1 (IC50 = 1 μM). Azalanstat is a stronger inhibitor of lanosterol 14a demethylase (rat and human Ki = 2.5 and 0.79 nM, respectively). The other three stereoisomers are weaker inhibitors of the demethylase. Target(s): aromatase, or CYP19; cholestanetriol 26-monooxygenase, or cholesterol 27-monooxygenase; cholesterol 7a-monooxygenase (CYP7)3,4; cholesterol monooxygenase, side-chain cleaving; CYP1A1; CYP1A2; CYP2C9; CYP2D6; heme oxygenase; progesterone 6b-monooxygenase, or CYP3A; progesterone 16a monooxygenase; steroid 11b monooxygenase; steroid 17a monooxygenase, or steroid 17a/20-lyase; steroid 21 monooxygenase; sterol 14-demethylase, or CYP5; lanosterol 14a-demethylase.

azalanstat Preparation Products And Raw materials

Raw materials

Peroxyacetic acid Methanesulfonyl chloride Sodium hydroxide Vinyl bromide 4-Aminothiophenol
4-Chlorophenethylalcohol Sodium hydride Oxalyl chloride p-Toluenesulfonic acid monohydrate Sodium acetate
Triphenylphosphine Triethylamine Potassium carbonate N-Bromosuccinimide Imidazole
Glycerol
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Preparation Products

azalanstat Suppliers

Global( 4)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 China 4659 58 Inquiry
Suzhou Meishi Biotechnology Co., Ltd. 1173954148q China 20035 58 Inquiry
TargetMol Chemicals Inc. 4008200310 China 23980 58 Inquiry
Supplier Advantage
TargetMol Chemicals Inc. 58
Nantong QuanYi Biotechnology Co., Ltd 58
Suzhou Meishi Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58

143393-27-5(azalanstat)Related Search:

azalanstat 1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole
azalanstat Azalanstat [inn] Benzenamine, 4-(((2-(2-(4-chlorophenyl)ethyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methyl)thio)-, (2S-cis)- Rs 21607 Rs-21607 Unii-2nl79ni1ws Benzenamine, 4-[[[(2S,4S)-2-[2-(4-chlorophenyl)ethyl]-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl]thio]- Azalanstat mesylate 143393-27-5