Ziprasidone
- CAS No.
- 146939-27-7
- Chemical Name:
- Ziprasidone
- Synonyms
- ZIPRASIDONE-D8;Geodon;CP 88059;Ziprasidone;Ziprasidone HBr;CP-88059：CP-88059-1;Ziprasidone solution;Ziprasidone Free Base;Ziprasidone USP/EP/BP;Hydrochloric acid(base)
- CBNumber:
- CB6167417
- Molecular Formula:
- C21H21ClN4OS
- Molecular Weight:
- 412.94
- MOL File:
- 146939-27-7.mol
- Modify Date:
- 2024/1/25 9:38:39
| Melting point | 213-215°C |
|---|---|
| Boiling point | 554.8±50.0 °C(Predicted) |
| Density | 1.369±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 13.34±0.20(Predicted) |
| color | Brown to Dark Brown |
| Merck | 14,10171 |
| CAS DataBase Reference | 146939-27-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H317-H373 |
| Precautionary statements | P260-P272-P280-P302+P352-P314-P333+P313 |
| Hazard Codes | F,T |
| Risk Statements | 60-61-11-19-38 |
| Safety Statements | 53-45 |
| RTECS | NM3241000 |
| HS Code | 2934.20.8000 |
Ziprasidone price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML3035 | Ziprasidone hydrochloride hydrate ≥97% (HPLC) | 146939-27-7 | 10MG | ₹9093 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML3035 | Ziprasidone hydrochloride hydrate ≥97% (HPLC) | 146939-27-7 | 50MG | ₹36707.58 | 2022-06-14 | Buy |
| TCI Chemicals (India) | Z0034 | Ziprasidone | 146939-27-7 | 100MG | ₹6100 | 2022-05-26 | Buy |
| TCI Chemicals (India) | Z0034 | Ziprasidone | 146939-27-7 | 1G | ₹18400 | 2022-05-26 | Buy |
Ziprasidone Chemical Properties,Uses,Production
Chemical Properties
Tan Solid
Uses
Labelled Ziprasidone, which is used as an antipsychotic. Combined serotonin (5HT2) and dopamine (D2) receptor antagonist.
Definition
ChEBI: A piperazine compound having 1,2-benzothiazol-3-yl- and 2-(6-chloro-1,3-dihydro-2-oxindol-5-yl)ethyl substituents attached to the nitrogen atoms.
Biological Functions
"Ziprasidone is chemically similar to risperidone but with a substitution of piperzinyl and benzisothiazole for piperidinyl and benzisoxazole and with minor aromatic modification. Like risperidone, ziprasidone is a high-affinity antagonist at 5-HT2A/C and D2 receptors as well as at adrenergic α1/α2 and histamine H1 receptors. Moreover, ziprasidone can activate 5-HT1A receptors that regulate dopaminergic neurotransmission in brain regions involved in critical cognitive functions. Thus, in addition to D2 partial agonism, 5-HT1A agonism is now thought to be an important pharmacological property for atypical antipsychotic drug efficacy.
General Description
Ziprasidone (Geodon, a benzisothiazolpiprazinylindolonederivative) also has the structuralfeatures of a hybrid molecule between a butyrophenone antipsychoticand a trazodone-like antidepressant. It is highlymetabolized to four major metabolites, only one of which, Smethyldihydroziprasidone,likely contributes to its clinical activity. In humans, less than 5% of the dose isexcreted unchanged. Reduction by aldehyde oxidase accountsfor about 66% of ziprasidone metabolism; two oxidative pathwaysinvolving hepatic CYP3A4 account for the remainder.
Mechanism of action
Ziprasidone (half-life, 6 hours) has an oral bioavailability of approximately 60%, which can be enhanced in the presence of fatty foods. It is extensively metabolized (<5% excreted unchanged) by aldehyde oxidase, which results in reductive cleavage of the S–N bond, and then by S-methylation. Ziprasidone also can undergo CYP3A4-catalyzed N-dealkylation and S-oxidation.
Ziprasidone Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| HRV Global Life Sciences | +91-9820219686 +91-9820219686 | Telangana, India | 379 | 58 | Inquiry |
| Svak Life Sciences | +91-9963463333 +91-9705383777 | Hyderabad, India | 101 | 58 | Inquiry |
| VIVAN Life Sciences Pvt Ltd | +91-2225870080 +91-9987465183 | Maharashtra, India | 49 | 58 | Inquiry |
| Ramdev Chemicals Pvt Ltd | +91-9320010324 +91-9320010323 | Maharashtra, India | 16 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Taj Mahal Vision Chemicals Private Limited | 07942557933 | Mumbai, India | 206 | 58 | Inquiry |
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