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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Metabolism >Dehydrogenase Inhibitor >2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide

2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide

2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide Structure
CAS No.
108605-62-5
Chemical Name:
2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide
Synonyms
Su 20;CS-862;Aubagio;Aids013145;Aids-013145;rac-A77 1626;Teriflunomide;(E/Z)-Teriflunomide;TeriflunoMide, A77 1726;Teriflunomide((E/Z) Mixture)
CBNumber:
CB6464433
Molecular Formula:
C12H9F3N2O2
Molecular Weight:
270.21
MOL File:
108605-62-5.mol
Modify Date:
2025/1/27 9:38:02
Request For Quotation

2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide Properties

Melting point 229-232°C
Boiling point 410.8±45.0 °C(Predicted)
Density 1.424±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 5 mg/ml with warming).
form Solid
pka 5.20±0.50(Predicted)
color White
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P264-P270-P301+P310-P405-P501
Hazard Codes  Xn
Risk Statements  22
HS Code  2926900005
Toxicity mouse,LD50,intraperitoneal,100mg/kg (100mg/kg),United States Patent Document. Vol. #5494911,

2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) PHR2878 Leflunomide Related Compound B pharmaceutical secondary standard, certified reference material 108605-62-5 50MG ₹56787.95 2022-06-14 Buy
Product number Packaging Price Buy
PHR2878 50MG ₹56787.95 Buy

2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide Chemical Properties,Uses,Production

Description

Teriflunomide (Aubagio®), also known as A77 1726, is an immunosupressant marketed by Sanofi for the teatment of multiple sclerosis (MS). Teriflunomide is the active metabolite of leflunomide, used for treatment of patients diagnosed with rheumatoid arthritis, and therefore simultaneously can be used as a treatment for rheumatoid arthritis.Teriflunomide acts as an inhibitor of the mitochondrial enzyme dihydrorotate dehydrogenase, inhibiting pyrimidine formation, and resulting in reduced B and T cell proliferation.

Chemical Properties

White Solid

Uses

The active metabolite of Leflunomide, 2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide can be used as a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis.

2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide Preparation Products And Raw materials

Raw materials

Preparation Products

2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide Suppliers

Global( 182)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Sekhment pharmaventures +91-9030088669 +91-9030088669 Mumbai, India 105 58 Inquiry
Glenmark Pharmaceuticals Limited +912240189999 Maharashtra, India 93 58 Inquiry
Alembic Pharmaceuticals Limited +91-2652280880 +91-2652280550 Gujarat, India 115 58 Inquiry
Honour Lab Limited +919845977466 Telangana, India 164 58 Inquiry
Unichem Laboratories Ltd +91-2266888333 +91-2266888333 Maharashtra, India 62 58 Inquiry
Shilpa Medicare Limited (SML) +91-8532238704 +91-9320649838 Karnataka, India 61 58 Inquiry
Aruvi Labs +91-8056181939 +91-8056181939 Tamil Nadu, India 149 58 Inquiry
Megafine Pharma +91 9867686666, +91 9665458868 Maharashtra, India 29 58 Inquiry
NATCO Pharma Limited +91-9849511345 +91-9866005199 Hyderabad, India 24 58 Inquiry
Ralington Pharma +91-7948911722 +91-9687771722 Gujarat, India 1350 58 Inquiry
Supplier Advantage
Sekhment pharmaventures 58
Glenmark Pharmaceuticals Limited 58
Alembic Pharmaceuticals Limited 58
Honour Lab Limited 58
Unichem Laboratories Ltd 58
Shilpa Medicare Limited (SML) 58
Aruvi Labs 58
Megafine Pharma 58
NATCO Pharma Limited 58
Ralington Pharma 58

2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide Spectrum

2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide(108605-62-5)1HNMR

108605-62-5(2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide)Related Search:

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N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide, 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-beuteamide, LEF-M (2Z)-2-[hydroxy-[[4-(trifluoromethyl)phenyl]amino]methylidene]-3-oxo-butanenitrile 2-Cyano-3OH-N-(4-trifluoromethylphenyl) crotonamide-d4 IMp. A (EP) as Hydrochloride: 4-(TrifluoroMethyl)aniline Hydrochloride TeriflunoMide, A77 1726 2-Cyano-3-hydroxy-N-(4-trifluoromethylphenyl)crotonamide 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide 2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide (E)-2-Cyano-3-hydroxy-N-(4-trifluoromethylphenyl)-2-butenamide 2-Butenamide, 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]- Aids013145 Aids-013145 Su 20 Teriflunomide (Z)-2-cyano-3-hydroxy-N-(4-(trifluoroMethyl)phenyl)but-2-enaMide Leflunomide Related Compound B (10 mg) (2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide) 2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide,teriflunomide Leflunomide Related Compound B (20 mg) (2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide) 2-cyano-3-hydroxy-n-(4-(trifluoromethyl)phenyl)-2-butenamid n-(4-trifluoromethylphenyl)-2-cyano-2-hydroxycrotonamide N-(4-TRIFLUOROMETHYLPHENYL)-2-CYANO-3-HYDROXYCROTOAMIDE N-(4-TRIFLUOROMETHYLPHENYL)-2-CYANO-3-HYDROXYCROTONAMIDE 2-CYANO-3-OH-N-(4-TRIFLUOROMETHYLPHENYL) CROTONAMIDE 2-CYANO-3-HYDROXY-N-[4-(TRIFLUOROMETHYL)PHENYL]-2-BUTENAMIDE Teriflunomide(Random Configuration) (2Z)-2-[hydroxy-[4-(trifluoromethyl)anilino]methylidene]-3-oxobutanenitrile Leflunomide ImpuritⅡ: 2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide CS-862 2-Cyano-3-hydroxy-N-(4-trifluoromethylphenyl)cro rac-A77 1626 Leflunomide impurityⅡ[2-cyano-3-hydroxy-N-(4’-trifluoromethylphenyl)-crotone amide] Aubagio 2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide USP/EP/BP Teriflunomide((E/Z) Mixture) Leflunomide USP Related Compound B Leflunomide Related Compound B (2-Cyano-3-hydroxy-N-(4''-trifluoromethylphenyl)-crotone amide) (1357056) Leflunomide impurityⅡ [2-cyano-3-hydroxy-N-(4’ -trifluoromethylphenyl)-croton e amide (E/Z)-Teriflunomide 2-cyano-3-hydroxy-crotonic acid 4-trifluoro-methyl-anilide A771726 (Teriflunomide), Active metabolite of leflunomide. Dihydroorotate dehydrogenase inhibitor. (E/Z)-Teriflunomide, 10 mM in DMSO 2-Cyano-3-hydroxy-N-(4-trifluoromethylphenyl)crotonamide/Leflunomide impurityⅡ 108605-62-5 C12H5F3N2O2D4 Various Metabolites and Impurities Metabolites & Impurities Tyrosine Kinase Inhibitors