Suberohydroxamic acid
- CAS No.
- 38937-66-5
- Chemical Name:
- Suberohydroxamic acid
- Synonyms
- ODHA;SBHA;[PTYR705]-STAT3;STAT3 (PTYR705);SUBEROHYDROXAMIC ACID;SUBERIC BISHYDROXAMATE;SuberohydroxaMic acid 95%;SuberoylBis-hydroxamicAci;suberic bishydroxamic acid;SUBEROYL BISHYDROXAMIC ACID
- CBNumber:
- CB6673028
- Molecular Formula:
- C8H16N2O4
- Molecular Weight:
- 204.22
- MOL File:
- 38937-66-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/18 11:31:13
Suberohydroxamic acid price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 559418 | SBHA - CAS 38937-66-5 - Calbiochem A cell-permeable bishydroxamic acid histone deacetylase (HDAC) inhibitor with anti-tumor properties. | 38937-66-5 | 100MG | ₹15469.99 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 390585 | Suberohydroxamic acid 95% | 38937-66-5 | 1G | ₹5130 | 2022-06-14 | Buy |
Suberohydroxamic acid Chemical Properties,Uses,Production
Description
Suberohydroxamic acid (SBHA) is a competitive histone deacetylase (HDAC) inhibitor that has been shown to inhibit HDAC1 (IC50 = 0.25 μM) and HDAC3 (IC50 = 0.30 μM). SBHA causes cell differentiation, cell cycle arrest, or apoptosis. HDAC inhibitors, including SBHA, act synergistically to kill cancer cells when used in combination with cytostatic drugs, allowing lower doses of both inhibitors and drugs to be used.
Uses
Histone deacetylase inhibitor. A cell-permeable inhibitor of HDAC1 and HDAC3. Shown to suppresses the growth of proliferating keratinocytes and squamous cell carcinoma cells.
Biological Activity
Suberoyl bis-hydroxamic acid (SBHA) is a Histone deacetylase (HDAC) inhibitor. SBHA inhibits the activity of HDAC1 and HDAC3 with IC50 values of 250 and 300 nM, respectively. SBHA inhibits proliferation, and induces apoptosis in several cancer cell lines. SBHA has been shown to activate Notch signaling in medullary thyroid carcinoma (MTC) cells.
Suberohydroxamic acid Preparation Products And Raw materials
Raw materials
Preparation Products
Suberohydroxamic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| Kindchem(Nanjing)Co.,Ltd | +86-025-025-85281586 +8618651653755 | China | 1227 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Hebei Duling International Trade Co. LTD | +8617333973358 | China | 15438 | 58 | Inquiry |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503259 +86-19930503259 | China | 18446 | 58 | Inquiry |
| PNP Biotech Co. Ltd | +8618516098983 | China | 1001 | 58 | Inquiry |
| Dalian Ruiying Technology Co., Ltd. | +86-0411-86907150 +86-15940963210 | China | 578 | 58 | Inquiry |
| LEAPCHEM CO., LTD. | +86-852-30606658 | China | 43348 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
38937-66-5(Suberohydroxamic acid)Related Search:
1of4
chevron_right