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CAY10603

CAY10603 Structure
CAS No.
1045792-66-2
Chemical Name:
CAY10603
Synonyms
Isox;187257;BML-281;CAY10603;HDAC6 Inhibitor;CAY10603 CAY10603;HDAC6 inhibitor ISOX;CAY10603; CAY-10603; CAY 10603.;Histone Deacetylase Inhibitor VIII - CAS 1045792-66-2 - Calbiochem;tert-butyl 4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenylcarbamate
CBNumber:
CB42590439
Molecular Formula:
C22H30N4O6
Molecular Weight:
446.5
MOL File:
1045792-66-2.mol
Modify Date:
2024/7/2 8:55:08
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CAY10603 Properties

Density 1.231±0.06 g/cm3(Predicted)
storage temp. +2C to +8C
solubility ≥22.35 mg/mL in DMSO; insoluble in EtOH; ≥24.85 mg/mL in H2O
form Beige to light brown solid
pka 9.47±0.20(Predicted)
color White to light yellow

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

CAY10603 Chemical Properties,Uses,Production

Description

Histone deacetylase 6 (HDAC6) is a class II HDAC that represses transcription by removing acetyl groups from histones. In addition, HDAC6 deacetylases tubulin, which is important in regulating microtubule stability and function. CAY10603 is a potent and selective inhibitor of HDAC6 (IC50 = 0.002 nM, as compared with 271, 252, 0.42, 6851, and 90.7 nM for HDAC1, 2, 3, 8, and 10, respectively). Also, CAY10603 prevents the growth of several pancreatic cancer cell lines (IC50 = 0.1-1 μM). The HDAC6 inhibitor is more active in inhibiting cell growth than the broad spectrum HDAC inhibitor suberoylanilide hydroxamic acid (SAHA).

General Description

A cell-permeable, active site Zn2+-targeting phenylisoxazolo-hydroxamate that acts a potent and highly selective HDAC6 inhibitor (IC50 = 0.002, 0.42, 90.7, 252, 271 and 6851 nM against HDAC-6, -3, -10, -2, -1 and -8, respectively). Shown to be more potent than SAHA in inhibiting the proliferation of a panel of pancreatic cancer cell lines (IC50<1.0 μM).

CAY10603 Preparation Products And Raw materials

Raw materials

Preparation Products

CAY10603 Suppliers

Global( 84)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Baynoe Chem (Suzhou) Co., Ltd. +86-512 65869404 +86-18934593683 China 257 58 Inquiry
LEAP CHEM CO., LTD. +86-852-30606658 China 24738 58 Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 China 11681 58 Inquiry
Suzhou Yuanrui Bio-Tech Co., Ltd +86-18106132862 +86-18106132862 China 285 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
Supplier Advantage
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
TargetMol Chemicals Inc. 58
InvivoChem 58
Baynoe Chem (Suzhou) Co., Ltd. 58
LEAP CHEM CO., LTD. 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58
Suzhou Yuanrui Bio-Tech Co., Ltd 58
Aladdin Scientific 58
Amadis Chemical Company Limited 58

CAY10603 Spectrum

CAY10603(1045792-66-2)MS

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N-[4-[3-[[[7-(Hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]carbamic acid 1,1-dimethylethyl ester HDAC6 inhibitor ISOX CAY10603 Isox tert-butyl 4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenylcarbamate HDAC6 Inhibitor Histone Deacetylase Inhibitor VIII - CAS 1045792-66-2 - Calbiochem CAY10603; CAY-10603; CAY 10603. 187257 tert-butyl N-[4-[3-[[7-(hydroxyamino)-7-oxoheptyl]carbamoyl]-1,2-oxazol-5-yl]phenyl]carbamate BML-281 Carbamic acid, N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-, 1,1-dimethylethyl ester BML 281,inhibit,Histone deacetylases,BML281,CAY-10603,Inhibitor,CAY10603,CAY 10603,HDAC CAY10603 CAY10603 1045792-66-2 Inhibitors