SPLITOMICIN
- CAS No.
- 5690-03-9
- Chemical Name:
- SPLITOMICIN
- Synonyms
- Spitomicin;Splitomycin;SPLITOMICIN;Splitomicin >1H-Benzo[f]chromen-3(2H)-one;1,2-Dihydro-3H-benzo[f]chromen-3-one;1,2-DIHYDRO-3H-NAPHTHO[2,1-B]PYRAN-3-ONE;2-Hydroxy-1-naphthalenepropanoic acid delta-lactone;Inhibitor,Histone deacetylases,Splitomycin,HDAC,inhibit,Splitomicin
- CBNumber:
- CB5227437
- Molecular Formula:
- C13H10O2
- Molecular Weight:
- 198.22
- MOL File:
- 5690-03-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
| WGK Germany | 3 |
| HS Code | 2932.20.4500 |
SPLITOMICIN price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | S4068 | Splitomicin ≥98% (HPLC), powder | 5690-03-9 | 5MG | ₹9190.43 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 567750 | Splitomicin - CAS 5690-03-9 - Calbiochem A cell-permeable lactone derived from β-naphthol that acts as a selective inhibitor of NAD+-dependent histone deacetylase activity of Sir2 protein (IC | 5690-03-9 | 5MG | ₹19050 | 2022-06-14 | Buy |
| TCI Chemicals (India) | S0892 | Splitomicin min. 98.0 % | 5690-03-9 | 200MG | ₹7800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | S0892 | Splitomicin min. 98.0 % | 5690-03-9 | 1G | ₹17500 | 2022-05-26 | Buy |
SPLITOMICIN Chemical Properties,Uses,Production
Uses
Splitomicin is a selective and potent inhibitor of Sir2 (silent information regulator 2), producing an inhibitory effect on neutrophils. Acts as an anti-inflammatory agent.
Definition
ChEBI: A benzochromenone that is 2,3-dihydro-1H-benzo[f]chromene substituted by an oxo group at position 3. It has been found to exhibit potential inhibitory activity against Sir2 proteins.
General Description
A cell-permeable and selective inhibitor of NAD+-dependent deacetylase activity of Sir2 protein (IC50 = 60 μM). Creates a phenocopy of the sir2 deletion mutant in S. cerevisiae and sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Reported to act by either altering or blocking access to the acetylated histone-binding pocket.
Biological Activity
Inhibitor of Sir2p (IC 50 = 60 μ M), an NAD + -dependent Sir2 family deacetylase required for chromatin-dependent silencing in yeast.
SPLITOMICIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | China | 49739 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
| Amadis Chemical Company Limited | 571-89925085 | China | 131980 | 58 | Inquiry |
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | China | 3989 | 66 | Inquiry |
| Angel Pharmatech, Ltd. | 17317130613 | China | 3246 | 58 | Inquiry |
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