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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Epigenetics >Sirtuin Inhibitors >SPLITOMICIN

SPLITOMICIN

SPLITOMICIN Structure
  • ₹7800 - ₹19050
  • Product name: SPLITOMICIN
  • CAS: 5690-03-9
  • MF: C13H10O2
  • MW: 198.22
  • EINECS:
  • MDL Number:MFCD08705254
  • Synonyms:SPLITOMICIN;1,2-DIHYDRO-3H-NAPHTHO[2,1-B]PYRAN-3-ONE;2-Hydroxy-1-naphthalenepropanoic acid delta-lactone;Splitomycin;1H-Benzo[f]chromen-3(2H)-one;Splitomicin >Spitomicin;1,2-Dihydro-3H-benzo[f]chromen-3-one
Price4 Properties Safety Information Description
4 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 5MG
  • 200MG
  • 1G
  • ManufacturerTCI Chemicals (India)
  • Product numberS0892
  • Product descriptionSplitomicin min. 98.0 %
  • Packaging200MG
  • Price₹7800
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberS0892
  • Product descriptionSplitomicin min. 98.0 %
  • Packaging1G
  • Price₹17500
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number567750
  • Product descriptionSplitomicin - CAS 5690-03-9 - Calbiochem A cell-permeable lactone derived from β-naphthol that acts as a selective inhibitor of NAD+-dependent histone deacetylase activity of Sir2 protein (IC
  • Packaging5MG
  • Price₹19050
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberS4068
  • Product descriptionSplitomicin ≥98% (HPLC), powder
  • Packaging5MG
  • Price₹9190.43
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) S0892 Splitomicin min. 98.0 % 200MG ₹7800 2022-05-26 Buy
TCI Chemicals (India) S0892 Splitomicin min. 98.0 % 1G ₹17500 2022-05-26 Buy
Sigma-Aldrich(India) 567750 Splitomicin - CAS 5690-03-9 - Calbiochem A cell-permeable lactone derived from β-naphthol that acts as a selective inhibitor of NAD+-dependent histone deacetylase activity of Sir2 protein (IC 5MG ₹19050 2022-06-14 Buy
Sigma-Aldrich(India) S4068 Splitomicin ≥98% (HPLC), powder 5MG ₹9190.43 2022-06-14 Buy

Properties

Melting point :73-74.5℃
storage temp. :2-8°C
solubility :insoluble in H2O; ≥44.2 mg/mL in EtOH with ultrasonic; ≥9.05 mg/mL in DMSO
form :solid
color :White to Almost white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330 Rinse mouth.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Sir2p, the product of the SIR2 gene, is a conserved NAD+-dependent histone deacetylase (HDAC) involved in the regulation of the lifespan in yeast. It plays roles in silencing gene expression and negatively regulates the initiation of DNA replication. Splitomicin is a small molecule inhibitor of Sir2p histone deacetylase activity, displaying higher activity in vivo (minimal inhibitory concentration = 0.49 μM) than in vitro (IC50 = 60 μM). It less effectively inhibits yeast Hst1, a paralog of Sir2p. Splitomicin has diverse effects on mammalian cells.

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