Procarbazine hydrochloride
- CAS No.
- 366-70-1
- Chemical Name:
- Procarbazine hydrochloride
- Synonyms
- PROCARBAZINE HCL;matulane;ibz;Mutulane;nsc-77213;nci-c01810;NSC-77213 HCl;natulanhydrochloride;ibenzmethyzinhydrochloride;PROCARBAZINE HYDROCHLORIDE
- CBNumber:
- CB6678902
- Molecular Formula:
- C12H20ClN3O
- Molecular Weight:
- 257.76
- MOL File:
- 366-70-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/21 22:41:43
| Melting point | 223°C |
|---|---|
| Density | 8.3 g/cm3 |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | DMSO: ≥18mg/mL |
| form | powder |
| color | white to tan |
| Water Solubility | >=10 g/100 mL at 21.5 ºC |
| Merck | 14,7758 |
| BCS Class | 3/1 |
| CAS DataBase Reference | 366-70-1(CAS DataBase Reference) |
| IARC | 2A (Vol. 26, Sup 7) 1987 |
| EPA Substance Registry System | Procarbazine hydrochloride (366-70-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H341-H350-H360 | |||||||||
| Precautionary statements | P201-P301+P312+P330-P308+P313 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 45-61-22-68 | |||||||||
| Safety Statements | 53-36/37-45 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | XS4725000 | |||||||||
| HS Code | 2928002500 | |||||||||
| Toxicity | LD50 orally in rats: 785 ±34 mg/kg (Goldenthal) | |||||||||
| NFPA 704 |
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Procarbazine hydrochloride price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML0036 | Procarbazine hydrochloride ≥98% (HPLC) | 366-70-1 | 10MG | ₹9601.78 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML0036 | Procarbazine hydrochloride ≥98% (HPLC) | 366-70-1 | 50MG | ₹38829.28 | 2022-06-14 | Buy |
| TCI Chemicals (India) | P2550 | Procarbazine Hydrochloride | 366-70-1 | 100MG | ₹3200 | 2022-05-26 | Buy |
| TCI Chemicals (India) | P2550 | Procarbazine Hydrochloride | 366-70-1 | 500MG | ₹9800 | 2022-05-26 | Buy |
Procarbazine hydrochloride Chemical Properties,Uses,Production
Chemical Properties
Crystalline Solid
Uses
Procarbazine hydrochloride USP is used to traet Hodgkin’s disease; non-Hodgkin’s lymphomas; lung cancer.
Definition
ChEBI: A hydrochloride obtained by combining procarbazine with one equivalent of hydrochloric acid. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaki g of DNA strands.
General Description
White to pale yellow crystalline powder with a slight odor. Acid to litmus.
Air & Water Reactions
In the presence of moisture or in aqueous solution undergoes oxidation by atmospheric oxygen. Water soluble.
Reactivity Profile
Procarbazine hydrochloride is very sensitive to light. Stability is highest in aqueous acid and decreases with increasing pH. Degrades rapidly in alcoholic media and more slowly in aqueous media .
Fire Hazard
Flash point data for Procarbazine hydrochloride are not available; however, Procarbazine hydrochloride is probably combustible.
Safety Profile
Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by an unspecified route. Moderately toxic by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and HCl. Used as a chemotherapeutic agent.
Potential Exposure
Procarbazine is available in capsule form. The primary use of this drug is as an antineoplastic agent in the treatment of advanced Hodgkin’s disease, and oat-cell carcinoma of the lung. The hydrochloride com- pound is used in treatment. The FDA approved use of pro- carbazine hydrochloride in 1969 and indicated that the drug should be used as an adjunct to standard therapy. Possible exposure occurs during manufacture of the drug and direct exposure during its subsequent administration to patients. Some of the metabolites of procarbazine hydrochloride are both carcinostatic and carcinogenic.
Shipping
UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
Incompatibilities
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.
Waste Disposal
It is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quanti- ties shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.
Procarbazine hydrochloride Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Surajlok Chemicals Pvt Ltd (Neon Laboratories Ltd) | +91-2268107000 +91-9987232509 | Maharashtra, India | 30 | 58 | Inquiry |
| MYLAN API US LLC | 080 6672 8000 | New Delhi, India | 44 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| K. R. Mehta And Co. | 08048978102 | Ahmedabad, India | 1 | 58 | Inquiry |
| Manus Aktteva | +91 (79) 6512-3395 | New Delhi, India | 581 | 34 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 | China | 3957 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12447 | 58 | Inquiry |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | China | 5867 | 58 | Inquiry |
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