5-Hydroxymethyluracil
- CAS No.
- 4433-40-3
- Chemical Name:
- 5-Hydroxymethyluracil
- Synonyms
- NSC 20901;AURORA KA-547;5-methyloluracil;α-HydroxythyMine;a-Hydroxythymine;uracil-5-methanol;TIMTEC-BB SBB000084;RARECHEM AH CK 0115;HYDROXYMETHYL URACIL;5-HYDROXYMETHYLURACIL
- CBNumber:
- CB7122987
- Molecular Formula:
- C5H6N2O3
- Molecular Weight:
- 142.11
- MOL File:
- 4433-40-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/18 11:31:03
| Melting point | >300 °C(lit.) |
|---|---|
| Density | 1.401±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly, Heated), Methanol (Slightly, Heated), Water (Slightly, Heated) |
| pka | 8.46±0.10(Predicted) |
| form | Solid |
| color | White |
| Water Solubility | Soluble in water. (50 g/L ) at 20°C, DMSO, dimethyl formamide or 100% ethanol. |
| BRN | 125482 |
| InChI | InChI=1S/C5H6N2O3/c8-2-3-1-6-5(10)7-4(3)9/h1,8H,2H2,(H2,6,7,9,10) |
| InChIKey | JDBGXEHEIRGOBU-UHFFFAOYSA-N |
| SMILES | C1(=O)NC=C(CO)C(=O)N1 |
| CAS DataBase Reference | 4433-40-3(CAS DataBase Reference) |
| EPA Substance Registry System | 2,4(1H,3H)-Pyrimidinedione, 5-(hydroxymethyl)- (4433-40-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | YR0513000 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29335990 | |||||||||
| NFPA 704 |
|
5-Hydroxymethyluracil price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 852589 | 5-(Hydroxymethyl)uracil 97% | 4433-40-3 | 1G | ₹2067.58 | 2022-06-14 | Buy |
| ALFA India | ALF-L01682-06 | 5-(Hydroxymethyl)uracil, 98% | 4433-40-3 | 5g | ₹9780 | 2022-05-26 | Buy |
| ALFA India | ALF-L01682-03 | 5-(Hydroxymethyl)uracil, 98% | 4433-40-3 | 1g | ₹2278 | 2022-05-26 | Buy |
5-Hydroxymethyluracil Chemical Properties,Uses,Production
Description
5-Hydroxymethyluracil is a product of oxidative damage to DNA, predominantly by hydroxyl radical via the Fenton reaction. It can be used as a potential epigenetic mark enhancing or inhibiting transcription with bacterial RNA polymerase.
Chemical Properties
White Powder
Uses
5-Hydroxymethyluracil (cas# 4433-40-3) is a compound useful in organic synthesis.
Definition
ChEBI: 5-hydroxymethyluracil is a primary alcohol that is uracil bearing a hydroxymethyl substituent at the 5-position. It has a role as a human metabolite. It is a primary alcohol and a pyrimidone. It derives from a uracil.
Biosynthesis
5-Hydroxymethyluracil is produced by the enzyme thymine dioxygenase (EC 1.14.11.6) which catalyzes the chemical reaction thymine + 2-oxoglutarate + O2 <-> 5-hydroxymethyluracil + succinate + CO2.
The 3 substrates of this enzyme are thymine, 2-oxoglutarate, and O2, whereas its 3 products are 5-hydroxymethyluracil, succinate, and CO2. The 5hmU base can also be generated by oxidation/hydroxylation of thymine by the Ten-Eleven-Translocation (TET) proteins or result from deamination of 5hmC. DNA containing 5hmU has been reported to be more flexible and hydrophilic.
Biotechnological Production
5-Hydroxymethyluracil (5hmU) is a thymine base modification found in the genomic DNA of diverse organisms ranging from bacteriophages to mammals.
5-Hydroxymethyluracil Preparation Products And Raw materials
Raw materials
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| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CHEMAZON LABORATORIES | +91 9848551964 | Hyderabad, India | 1320 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Sense Chemicals (Shanghai) Co., Ltd. | +86-21-52751036; +8613818977689 | China | 224 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29901 | 58 | Inquiry |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | China | 6387 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| CHEMAZON LABORATORIES | 58 |
| Alfa Aesar | 58 |
| CHEMSWORTH | 30 |
| CLEARSYNTH LABS LTD. | 58 |
| A.J Chemicals | 58 |
| Sense Chemicals (Shanghai) Co., Ltd. | 58 |
| ATK CHEMICAL COMPANY LIMITED | 60 |
| career henan chemical co | 58 |
| Xiamen AmoyChem Co., Ltd | 58 |
| Chongqing Chemdad Co., Ltd | 58 |