Calcium citrate
- CAS No.
- 813-94-5
- Chemical Name:
- Calcium citrate
- Synonyms
- Tricalcium citrate;tribasiccalciumcitrate;Tricalcium Citrate anhydrous;citrical;acicontral;Calsium citrate;Calcium citrate;DICALCIUMCITRATE;CALCIUM CITRATE USP;TRICALCIUM DICITRATE
- CBNumber:
- CB7153589
- Molecular Formula:
- C12H10Ca3O14
- Molecular Weight:
- 498.43
- MOL File:
- 813-94-5.mol
- Modify Date:
- 2024/5/27 17:30:58
| solubility | 0.1 M HCl: 0.01 M at 20 °C, clear, colorless |
|---|---|
| Odor | at 100.00?%. odorless |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| LogP | -1.721 (est) |
| CAS DataBase Reference | 813-94-5(CAS DataBase Reference) |
| EPA Substance Registry System | Tricalcium citrate (813-94-5) |
Calcium citrate Chemical Properties,Uses,Production
Description
Calcium citrate is the calcium salt of citric acid. It is commonly used as a food additive (E333), usually as a preservative, but sometimes for flavor. In this sense, it is similar to sodium citrate. Calcium citrate is also used as a water softener because the citrate ions can chelate unwanted metal ions. Calcium citrate is also found in some dietary calcium supplements (e.g. Citracal). Calcium makes up 21% of calcium citrate by weight.
Chemical Properties
white powder or white to colourless crystals
Production Methods
Calcium citrate is an intermediate in the isolation of citric acid from the fermentation process by which citric acid is produced industrially. The citric acid in the broth solution is neutralized by calcium hydroxide, precipitating insoluble calcium citrate. This is then filtered off from the rest of the broth and washed to give clean calcium citrate.
The calcium citrate thus produced may be sold as-is, or it may be converted to citric acid using dilute sulfuric acid.
Pharmaceutical Applications
Calcium citrate is more easily absorbed (bioavailability is 2.5 times higher than calcium carbonate); it is easier to digest and less likely to cause constipation and gas than calcium carbonate. Calcium citrate can be taken without food and is more easily absorbed than calcium carbonate on an empty stomach. It is also believed that it contributes less to the formation of kidney stones. Calcium citrate consists of around 24% Ca2+, which means that 1000 mg calcium citrate contains around 240 mg Ca2+. The lower Ca2+ content together with the higher price makes it a more expensive treatment option compared to calcium carbonate, but its slightly different application field can justify this.
Biological Activity
In many individuals, bioavailability of calcium citrate is found to be equal to that of the cheaper calcium carbonate.However, alterations to the digestive tract may change how calcium is digested and absorbed. Unlike calcium carbonate, which is basic and neutralizes stomach acid, calcium citrate has no effect on stomach acid. Individuals who are sensitive to antacids or who have difficulty producing adequate stomach acid should choose calcium citrate over calcium carbonate for supplementation. According to recent research into calcium absorption after gastric bypass surgery , calcium citrate may have improved bioavailability over calcium carbonate in Rouxen- Y gastric bypass patients who are taking calcium citrate as a dietary supplement after surgery. This is mainly due to the changes related to where calcium absorption occurs in the digestive tract of these individuals.
Calcium citrate Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Advantage |
|---|---|
| Indiana ChemPort | 58 |
| SL Drugs & Pharmaceuticals | 58 |
| S.V ENTERPRISES | 58 |
| New Alliance Dye Chem Pvt Ltd | 58 |
| Annexe Chem Pvt Ltd | 58 |
| HRV Global Life Sciences | 58 |
| ShanPar Industries Pvt Ltd | 58 |
| Paxy Chem | 58 |
| EAGLE CHEMICAL WORKS | 58 |
| West Bengal Chemical Industries Ltd. | 58 |
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