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1-Bromoethyl acetate

1-Bromoethyl acetate Structure
CAS No.
40258-78-4
Chemical Name:
1-Bromoethyl acetate
Synonyms
1-BROMOETHYLACETATE;Cefuroxim Impurity 16;Cefuroxime Impurity 51;1-ACETOXY ETHYL BROMIDE;Theophylline Impurity 10;1-Bromoethyl acetate ,90%;1-Bromoethyl acetate[BEA];1 - broMine ethyl acetate;1-bromo-Ethanol 1-acetate;(RS)-1-Acetoxyethyl BroMide
CBNumber:
CB7171112
Molecular Formula:
C4H7BrO2
Molecular Weight:
167
MOL File:
40258-78-4.mol
MSDS File:
SDS
Modify Date:
2025/2/27 20:32:11

1-Bromoethyl acetate Properties

Boiling point 122-125 °C(Press: 738 Torr)
Density 1.48
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility Chloroform (Sparingly), Methanol (Sparingly)
form Oil
color Colourless to Dark Brown
Stability Hygroscopic
InChI InChI=1S/C4H7BrO2/c1-3(5)7-4(2)6/h3H,1-2H3
InChIKey IIASCQBFNHWZBE-UHFFFAOYSA-N
SMILES C(OC(=O)C)(Br)C

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS02,GHS07
Signal word  Warning
Hazard statements  H335-H226-H315-H319
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
Safety Statements  24/25
HS Code  29153900

1-Bromoethyl acetate Chemical Properties,Uses,Production

Chemical Properties

Pale Yellow Oil

Uses

1-Bromoethyl Acetate is a 1-haloalkyl ester that is used in the modification of of antibiotics. It is an intermediate that can be usefully used in the preparation of the oral antibiotic Cefuroxime axetil. 

Synthesis

1-bromoethyl acetate is prepared by reacting acetyl bromide and acetaldehyde using zinc chloride as a catalyst. 
After cooling 30 ml of hydrogen bromide / acetic acid (1.2 equiv) to 0 ° C., 53.5 ml (1.0 equiv) of vinyl acetate was slowly added thereto, followed by stirring for 1 hour. It was extracted with dichloromethane, washed with distilled water at 0-5 ° C., dehydrated with anhydrous magnesium sulfate, and distilled under reduced pressure to obtain 81.4 g of 1-bromoethyl acetate.
synthesis of 1-bromoethyl acetate

1-Bromoethyl acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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1-ACETOXY ETHYL BROMIDE 1-BROMOETHYLACETATE 1-Bromoethyl acetate ,90% (RS)-1-Acetoxyethyl BroMide 1 - broMine ethyl acetate 1-Bromoethyl acetate[BEA] Cefuroxime Impurity 51 1-Acetoxy Ethyl Bromide (1-AEB) CAS No. : 40258-78-4 1‐Acetoxy?Ethyl?Bromide?(1‐AEB) Ethanol, 1-bromo-, 1-acetate Theophylline Impurity 10 1-bromo-Ethanol 1-acetate 1-Bromo ethyl acetate Cefuroxime Axetil intermediate Cefuroxim Impurity 16 40258-78-4