Daidzein
- CAS No.
- 486-66-8
- Chemical Name:
- Daidzein
- Synonyms
- 7-HYDROXY-3-(4-HYDROXY-PHENYL)-CHROMEN-4-ONE;k251b;GMP-5;Tatoin;Daizeol;K 251-6;Daidsein;DAIDZEIN;NPI 031E;daidzeol
- CBNumber:
- CB7173989
- Molecular Formula:
- C15H10O4
- Molecular Weight:
- 254.24
- MOL File:
- 486-66-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/24 15:44:31
| Melting point | 315-323°C (dec.) |
|---|---|
| Boiling point | 317.45°C (rough estimate) |
| Density | 1.1629 (rough estimate) |
| refractive index | 1.4300 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO: 10 mg/mL |
| form | Powder |
| pka | 7.01±0.20(Predicted) |
| color | White to off-white |
| Water Solubility | insoluble |
| Merck | 14,2801 |
| BRN | 231523 |
| LogP | 2.632 (est) |
| CAS DataBase Reference | 486-66-8(CAS DataBase Reference) |
| EPA Substance Registry System | 4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-hydroxyphenyl)- (486-66-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/38 | |||||||||
| Safety Statements | 24-26-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DJ3100040 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29329990 | |||||||||
| NFPA 704 |
|
Daidzein price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | D7802 | Daidzein ≥98%, synthetic | 486-66-8 | 25MG | ₹11030.68 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1858 | Daidzein Pharmaceutical Secondary Standard; Certified Reference Material | 486-66-8 | 100MG | ₹15144.18 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D7802 | Daidzein ≥98%, synthetic | 486-66-8 | 100MG | ₹35906.53 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 251600 | Daidzein - CAS 486-66-8 - Calbiochem Inactive analog of Genistein. | 486-66-8 | 25MG | ₹9490 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 16587 | Daidzein analytical standard | 486-66-8 | 10MG | ₹17817.95 | 2022-06-14 | Buy |
Daidzein Chemical Properties,Uses,Production
Description
Daidzein mainly comes from leguminous plants, the seeds of soybean (dadou), red clover grass, or all Pueraria roots. Its medicinal value was first recorded in Shen Nong Ben Cao Jing 2838 BC.?Daidzein, one of the main soy isoflavones, is also the main component of radix puerariae (Gegen) which is the dry root of kudzu leguminous plants. Radix puerariae can reduce fever, produce saliva, and relieve diarrhea. Its chemical composition is complicated, including puerarin, xyloside, soy flavonoids, soybean flavonoid glycosides, beta-sitosterol, daidzin, daidzein. The main effective components are puerarin and daidzein
Chemical Properties
Off-White Crystalline Solid
Physical properties
Appearance: pale-yellow prismatic crystal. Melting point: 315–323?°C. Solubility: soluble in ethanol and ether
History
Daidzein is a kind of isoflavone compound, which was first synthetized by researchers in China. It has been widely used in drugs, food supplements, and cosmetics.
Because of two phenolic hydroxyl structures, Daidzein has poor water solubility,
poor liposolubility, and strong first-pass effect, leading to the low bioavailability of
oral absorption, which limits its widely clinical usage.
Ipriflavone is a kind of isoflavone modified from Daidzein, which has been used
for the treatment of osteoporosis in Japan and some European countries. The effects
of a series of amino alkoxy derivatives of ipriflavones on inhibiting the bone absorption were evaluated. The researchers found that 7-amino alkoxy derivative works
best. When Daidzein was alkylated or acylated at 7-hydroxyl selectively, the stability was increased, and thus the proliferation of MCF-7 cell was inhibited.
Uses
Inactive analog of Genistein (Cat. #G350000). Blocks the G1 phase of the cell cycle in Swiss 3T3 cells by inhibiting casein kinase II activity1. Daidzein has also been shown to inhibit the action of GABA on recombinant GABAA receptors2. uv max:250 nm (log e 4.44)
Indications
Daidzein is mainly used for the treatment of hypertension, coronary heart disease, cerebral thrombosis, and vertigo and aids in the treatment of sudden deafness. It can also treat women with menopause syndrome.
Definition
ChEBI: A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone substituted by an additional hydroxy group at position 4'.
General Description
Daidzein is an endocrine-active estrogenic isoflavone. This phytoestrogen is capable to bind to estrogen to exert estrogenic effects in vivo. It can naturally be found in soybean seed and flour.
Biological Activity
Analog of the phytoestrogen genistein (5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one ). Blocks G 1 phase cell cycle progression and is an agonist at estrogen receptors.
Clinical Use
Daidzein can expand the coronary artery, femoral artery, and cerebral artery, increase cerebral blood flow and limb blood circulation, reduce blood viscosity and vascular resistance, decrease myocardial oxygen consumption, improve heartfunction, increase the microcirculation and blood flow to the tip, lower the blood pressure, and adjust the heart rhythm. Daidzein can be used for the treatment of hypertension, coronary heart disease, angina pectoris, myocardial infarction, cerebral thrombosis, dizziness, and sudden deafness. It can also be used for women’s menopause syndrome.
Daidzein Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Biosyn Research Chemicals | +91 9346022300/+91 9399339999 | Telangana, India | 1340 | 58 | Inquiry |
| VASIN BIO LIFE SCIENCES PVT LTD | 9491644688 | Hyderabad, India | 2096 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Evans Fine Chem | 08048602255 | Hyderabad, India | 289 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| CHEMSWORTH | 30 |
| CLEARSYNTH LABS LTD. | 58 |
| A.J Chemicals | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Otto Chemie Pvt. Ltd. | 58 |
| Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |
| Biosyn Research Chemicals | 58 |
| VASIN BIO LIFE SCIENCES PVT LTD | 58 |
| Pharma Affiliates | 58 |
| Evans Fine Chem | 58 |
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