Carbenicillin disodium

Carbenicillin disodium Properties

Melting point	>190°C (dec.)
alpha	+175～+190°(D/20℃)(c=4,H2O)(calculated on the dehydrous basis)
storage temp.	Inert atmosphere,2-8°C
solubility	H₂O: 50 mg/mL
form	powder
color	white to off-white
PH	5.5～7.5 (10g/l, 25℃)
Water Solubility	Soluble in water.
Merck	13,1801
BRN	5722128

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Danger
Hazard statements	H317-H334
Precautionary statements	P261-P272-P280-P284-P302+P352-P333+P313
Hazard Codes	Xn
Risk Statements	42/43
Safety Statements	22-36/37-36
RIDADR	UN 1170 3/PG 3
WGK Germany	2
RTECS	ON9105000
F	3-8-10
HS Code	29411000
Toxicity	LD50 i.p. in rats: >2000 mg/kg (Goldenthal)

Carbenicillin disodium price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	C9231	Carbenicillin disodium meets USP testing specifications	4800-94-6	1G	₹19517.48	2022-06-14	Buy
Sigma-Aldrich(India)	C9231	Carbenicillin disodium meets USP testing specifications	4800-94-6	5G	₹69561.45	2022-06-14	Buy
Sigma-Aldrich(India)	C9231	Carbenicillin disodium meets USP testing specifications	4800-94-6	10G	₹92304.78	2022-06-14	Buy
Sigma-Aldrich(India)	C3416	Carbenicillin disodium salt BioReagent, suitable for plant cell culture	4800-94-6	250MG	₹6754.8	2022-06-14	Buy
Sigma-Aldrich(India)	C3416	Carbenicillin disodium salt BioReagent, suitable for plant cell culture	4800-94-6	1G	₹21238.65	2022-06-14	Buy

Product number	Packaging	Price	Buy
C9231	1G	₹19517.48	Buy
C9231	5G	₹69561.45	Buy
C9231	10G	₹92304.78	Buy
C3416	250MG	₹6754.8	Buy
C3416	1G	₹21238.65	Buy

Carbenicillin disodium Chemical Properties,Uses,Production

Description

Carbenicillin is a broad-spectrum carboxypenicillin antibiotic. It is active against Gram-negative and certain Gram-positive bacteria, including S. pyogenes, S. epidermidis, P. mirabilis, P. vulgaris, E. coli, and P. aeruginosa (MICs = 0.19, 1.56, 1.56, 3.12, 3.12, and 50 μg/ml, respectively). It is also active against penicillinase-producing and non-producing strains of S. aureus (MICs = 1.56 and 12.5 μg/ml, respectively). Carbenicillin is protective against systemic S. pyogenes, P. vulgaris, E. coli, and S. aureus infection in a mouse model of systemic lethal infection with 50% protective dose (PD₅₀) values of 7.8, 224, 19.3, and 34 mg/kg, respectively. It also decreases viable colony counts in the kidney in a rat model of P. vulgaris or E. coli urinary tract infection when administered at a dose of 100 mg/kg. Formulations containing carbenicillin have previously been used in the treatment of upper and lower urinary tract infections and prostatitis.

Chemical Properties

white Powder

Uses

Carbenicillin disodium salt is a water-soluble antibiotic which is effective against gram-negative bacteria.Carbenicillin disodium salt is widely utilized as an antibiotic which is used to control bacterial cell-wall synthesis by inactivating transpeptidases on the inner surface of the bacterial cell membrane. It has been involved in the study of the role of penicillin-sensitive transpeptidases in cell wall biosynthesis.

General Description

Carbenicillin was synthesized by Brain et al. of Beecham Research Laboratories in 1965. It was the first synthetic penicillin to show activity against Pseudomonas aeruginosa. Although its activity against the microorganism is not strong (MIC = 25 – 100 μg/mL), it is widely used against P. aeruginosa infections because of its low toxicity and the lack of other antibiotics suitable for use against this microorganism. Carbenicillin is mainly used clinically to treat urinary tract and respiratory tract infections and sepsis caused by Proteus, Escherichia coli, Klebsiella, and Pseudomonas aeruginosa.

Clinical Use

Carbenicillin disodium, disodium α-carboxybenzylpenicillin(Geopen, Pyopen), is a semisynthetic penicillin releasedin the United States in 1970, which was introduced inEngland and first reported by Ancred et al. in 1967.Examination of its structure shows that it differs from ampicillinin having an ionizable carboxyl group rather than anamino group substituted on the α-carbon atom of the benzylside chain. Carbenicillin has a broad range of antimicrobialactivity, broader than any other known penicillin, a propertyattributed to the unique carboxyl group. It has been proposedthat the carboxyl group improves penetration of themolecule through cell wall barriers of Gram-negativebacilli, compared with other penicillins.
Carbenicillin is not stable in acids and is inactivated bypenicillinase. It is a malonic acid derivative and, as such, decarboxylatesreadily to penicillin G, which is acid labile.Solutions of the disodium salt should be freshly prepared but,when refrigerated, may be kept for 2 weeks. It must be administeredby injection and is usually given intravenously.
Carbenicillin has been effective in the treatment of systemicand urinary tract infections caused by P. aeruginosa,indole-producing Proteus spp., and Providencia spp., all ofwhich are resistant to ampicillin. The low toxicity of carbenicillin,with the exception of allergic sensitivity, permits theuse of large dosages in serious infections. Most cliniciansprefer to use a combination of carbenicillin and gentamicinfor serious pseudomonal and mixed coliform infections. Thetwo antibiotics are chemically incompatible, however, andshould never be combined in an intravenous solution.

Carbenicillin disodium Preparation Products And Raw materials

Raw materials

Thionyl chloride Hydrogen Sodium bicarbonate Benzyl alcohol Phenylmalonic acid

6-Aminopenicillanic acid

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Preparation Products

Carbenicillin disodium Suppliers

Global( 365)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
Otto Chemie Pvt. Ltd.	+91 9820041841	Mumbai, India	5873	58	Inquiry
Sisco Research Laboratories Pvt. Ltd.	+91-22-4268 5800	Mumbai, India	4317	58	Inquiry
Triveni chemicals	08048762458	New Delhi, India	6093	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Ayonex Labs Private Limited	08045911767	Punjab, India	12	58	Inquiry
Anand Agencies	91-20-24454597	Maharashtra, India	2337	58	Inquiry
Maas Pharma Chemicals	+91-9958666224	Delhi, India	1607	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6761	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58
Otto Chemie Pvt. Ltd.	58
Sisco Research Laboratories Pvt. Ltd.	58
Triveni chemicals	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Ayonex Labs Private Limited	58
Anand Agencies	58
Maas Pharma Chemicals	58
Pharma Affiliates	58

Carbenicillin disodium Spectrum

Carbenicillin disodium(4800-94-6)MS

4800-94-6(Carbenicillin disodium)Related Search:

Sodium chloride Ampicillin sodium CARBENICILLIN Penicillin G Penicillin G sodium salt

Ethylenediaminetetraacetic acid disodium salt Chlorodimethylphenylsilane Sulbenicillin sodium Sodium Monofluorophosphate 8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT

Sodium phenylacetate Carboxy styrene-butadiene latex Carbenicillin Disodium Salt SODIUM ISOVALERATE Penicillin

3-AMINO-2-PHENYL-PROPIONIC ACID SODIUM ISOBUTYRATE Carbenicillin disodium

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disodiumcarbenicillin fugacillin 6-[(CARBOXYPHENYLACETYL)-AMINO]-3,3-DIMETHYL-7-OXO-4-THIA-1-AZA-BICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID, 2NA ANABACTYL ALPHA-CARBOXYBENZYLPENICILLIN ALPHA-CARBOXYBENZYLPENICILLIN DISODIUM SALT CARBENICILLIN DISODIUM SALT USP CARBENICILLIN MONOSODIUM USP(CRM STANDARD) CARBENICILLIN MONOSODIUM WHO(CRM STANDARD) CARBENCILLIN SODIUM Carbenicillinedisodiumsalt Carbenicillinesodium Carbenicillin DisodiuM (90%) DISODIUM ALPHA-CARBOXYBENZYLPENICILLIN disodium [2s-(2alpha,5alpha,6beta)]-6-(carboxylatophenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate CARBENICILLIN DISODIUM CARBENICILLIN DISODIUM SALT CARBENICILLIN-NA2-SALT CARBENICILLIN SODIUM CARBENICILLIN SODIUM SALT CARBENCILIN, DISODIUM SALT α-Carboxybenzylpenicillin disodium salt CARBENICILLIN DISODIUM PLANT CELLCULTURE TESTED CARBENICILLIN DISODIUM SALT, BIOTECHNOLO CARBENICILLIN READY MADE SOLUTION CARBENICILLIN DISODIUM USP CARBENICILLIN DISODIUM SALT CELL CULTURE GRADE Carbenicillin Na2 Carbenicillin sodium salt, Antibiotic for Culture Media Use Only α-Carboxybenzylpenicillin disodium salt Carbenicillin disodium salt gripenin hyoper microcillin nsc-111071 piopen pyopene MonoclonalAntibodytoProcathepsinW(Human)(CW40-1B1) CARBENICILIN 4-Thia-1-azabicyclo3.2.0heptane-2-carboxylic acid, 6-(carboxyphenylacetyl)amino-3,3-dimethyl-7-oxo-, disodium salt, (2S,5R,6R)- 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[(carboxyphenylacetyl)amino]-3,3-dimethyl-7-oxo-, disodium salt, [2S-(2α,5α,6β)]- Carbapen Carbenicilline disodium Disodium (α-carboxybenzyl)penicillin Malonamic acid, N-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-6-yl)-2-phenyl-, disodium salt (7CI, 8CI) Sodium carbenicillin α-Carboxybenzylpenicillin sodium salt Carbenicillin, 2Na SYNONYMΑ-CARBOXYBENZYLPENICILLINDISODIUMSALT Carbenicillin disodi 6-[(Carboxyphenylacetyl)-amino]-3,3-dimethyl-7-oxo-[2S-(2,5,6)-4-thia-1-aza-bicyclo[3.2.0]-heptane-2-carboxylate sodium a-Carboxybenzylpenicillin disodium salt 6-[(2-Carboxy-2-phenyl-acetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 6-[(2-carboxy-2-phenylacetyl)aMino]-3,3-diMethyl-7-oxo-, sodiuM salt(1:2), (2S,5R,6R)- (2S,5R,6R)-6-[(2-Carboxy-2-phenylacetyl)aMino]-3,3-diMethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid SodiuM Salt N-(2-Carboxy-3,3-diMethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-6-yl)-2-phenylMalonaMic Acid DisodiuM brl-2064 carbecin carboxybenzylpenicillinsodium