Argatroban
- CAS No.
- 74863-84-6
- Chemical Name:
- Argatroban
- Synonyms
- Argatraban;(2R,4R)-4-Methyl-1-[N-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl)sulfonyl]-L-arginyl]-2-piperidinecarboxylic acid;MQP;MQPA;MD-805;ARG025;OM 805;DK-7419;Slonnon;MCI-9038
- CBNumber:
- CB7738830
- Molecular Formula:
- C23H36N6O5S
- Molecular Weight:
- 508.63
- MOL File:
- 74863-84-6.mol
- Modify Date:
- 2023/6/30 15:45:59
| Melting point | 188-1890C |
|---|---|
| Boiling point | 777.2±70.0 °C(Predicted) |
| Density | 1.47±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | Soluble in DMSO (up to 50 mg/ml). |
| pka | 10.44±0.40(Predicted) |
| form | White to off-white powder. |
| color | White |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
| InChIKey | KXNPVXPOPUZYGB-IOVMHBDKSA-N |
| SMILES | N1(C(=O)[C@@H](NS(C2C3=C(C=CC=2)CC(C)CN3)(=O)=O)CCCNC(N)=N)CC[C@@H](C)C[C@@H]1C(O)=O |
| CAS DataBase Reference | 74863-84-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H311-H331 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P302+P352-P304+P340-P310-P330-P361-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
Argatroban Chemical Properties,Uses,Production
Description
Argatroban is a new synthetic antithrombotic agent useful in maintenance anticoagulation them ischemic stroke and disseminated intravascular coagulation. In patients on hemodialysis, argatroban is su enor to heparin, generating a more stable antithrombin effect. Other potential uses include progressing ischemic stroke and disseminated intravascular coagulation.
Chemical Properties
White to Off-White Crystalline Solid
Pharmacokinetics
Argatroban is administered subcutaneously because of the low lipophilicity of the drug. The drug is bound to plasma protein and is metabolized via CYP3A4/5 to the aromatized metabolite and the two hydroxylated metabolites. The M-1 metabolite retains 20 to 30% of the antithrombotic activity. Coadministration of argatroban with inhibitors of CYP3A4 does not appear to produce clinically significant effects. Argatroban is eliminated via biliary secretion into the feces.
Clinical Use
Argatroban has been approved for the prophylaxis and treatment of thrombosis in patients with HIT (79). Argatroban is a peptidomimetic that binds selectively to the catalytic site of thrombin as a univalent competitive DTI. Argatroban is available as a mixture of 21-R and 21-S diastereomers (64:36), with the S-isomer approximately twice as potent as the R-isomer. The drug is a reversible inhibitor of both free thrombin as well as clot-bound thrombin.
Argatroban Preparation Products And Raw materials
Raw materials
1of2
chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Anant Pharmaceuticals Pvt Ltd | +91-8550986868 +91-9485998001 | Haryana, India | 461 | 58 | Inquiry |
| Global Calcium Pvt Ltd | +91-8050750904 +91-8040554500 | Karnataka, India | 132 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| Manus Aktteva Biopharma LLP | 08048250218Ext 800 | Ahmedabad, India | 655 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Apan Imex Private Limited | 91-79-26850087 | Gujarat, India | 31 | 58 | Inquiry |
| Athos Chemicals | 91-9998858909 | Gujarat, India | 315 | 58 | Inquiry |
| Manus Aktteva | +91 (79) 6512-3395 | New Delhi, India | 581 | 34 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Anant Pharmaceuticals Pvt Ltd | 58 |
| Global Calcium Pvt Ltd | 58 |
| Clearsynth Labs | 58 |
| Manus Aktteva Biopharma LLP | 58 |
| Pharma Affiliates | 58 |
| Apan Imex Private Limited | 58 |
| Athos Chemicals | 58 |
| Manus Aktteva | 34 |
| CLEARSYNTH LABS LTD. | 58 |
| A.J Chemicals | 58 |
74863-84-6(Argatroban)Related Search:
1of4
chevron_right