Suplatast tosilate
- CAS No.
- 94055-76-2
- Chemical Name:
- Suplatast tosilate
- Synonyms
- Suplatast tosylate;IPD-1151T;Suplatast;SUPLATAST TOSILATE;Suplatast Tosylate >Methotrexate Impurity 47;Suplatast tosilate USP/EP/BP;Suplatast Tosylate (IPD 1151T);TIANFU CHEM--Suplatast tosilate;N,N-dimethyl-2-propyl-1-pentanamine
- CBNumber:
- CB8837187
- Molecular Formula:
- C23H33NO7S2
- Molecular Weight:
- 499.64062
- MOL File:
- 94055-76-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/6 16:20:44
| Melting point | 84-87°C |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO: >20mg/mL |
| form | powder |
| color | white to off-white |
| Merck | 14,9003 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. |
| CAS DataBase Reference | 94055-76-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | 3 |
| RTECS | WR7906000 |
| HS Code | 2930.90.2900 |
| Toxicity | LD50 in male, female mice, male, female rats (mg/kg): 81, 96, 96, 93 i.v.; in mice, rats (g/kg): >12.5, >10 orally (Yamashita) |
Suplatast tosilate price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | S4701 | Suplatast tosylate ≥98% (HPLC) | 94055-76-2 | 50MG | ₹35062.18 | 2022-06-14 | Buy |
| TCI Chemicals (India) | S0875 | Suplatast Tosylate | 94055-76-2 | 100MG | ₹6700 | 2022-05-26 | Buy |
| TCI Chemicals (India) | S0875 | Suplatast Tosylate | 94055-76-2 | 1G | ₹14500 | 2022-05-26 | Buy |
Suplatast tosilate Chemical Properties,Uses,Production
Description
Suplatast tosylate is a unique dimethylsulfonium salt marketed in Japan for the treatment of bronchial asthma, atopic dermatitis and allergic rhinitis. Suplatast tosylate is a potent inhibitor of IgE synthesis without suppressing IgM and IgG. The mechanism of action for suplatast tosylate is thought to be via the inhibition of interleukin-4 and interleukin-6 production by T-cells at the gene level. In allergic patients, suplatast tosylate markedly improved clinical symptoms which correlated with a significant decrease in serum IgE antibody levels.
Uses
Suplatast Tosilate is a novel capsular anti-asthmatic agent that suppresses both IgE production, IL-4 and IL-5 synthesis with IC50 above 100 μM.
Biological Activity
Th2 cytokine inhibitor that attenuates IL-2, IL-5 and IL-13 production and has no effect on IFN- γ production. Acts as an immunoregulator that suppresses IgE production, eosinophil infiltration and histamine release. Exhibits antiasthmatic, anti-inflammatory and antifibrotic activity in vivo and is orally active.
Suplatast tosilate Preparation Products And Raw materials
Raw materials
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Global( 168)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Lifecare Laboratories Pvt. Ltd | +91-4023750123 +91-4023750123 | Hyderabad, India | 18 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Pharmaffiliates Analytics & Synthetics (P) Ltd. | 91-172-5066494 | Haryana, India | 631 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12558 | 58 | Inquiry |
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | China | 7181 | 58 | Inquiry |
94055-76-2(Suplatast tosilate)Related Search:
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(2-(4-(3-ethoxy-2-hydroxypropoxy)phenylcarbamoyl)ethyl)dimethylsulfonium p-toluenesulfonate
2-[4-(2-Hydroxy-3-ethoxypropoxy)phenylcarbamoyl]ethyldimethylsulfonium·4-methylbenzenesulfonate
IPD-1151T
S,S-Dimethyl-3-oxo-3-[4-(2-hydroxy-3-ethoxypropoxy)anilino]propane-1-sulfonium·4-methylbenzenesulfonate
[2-[[[4-(2-Hydroxy-3-ethoxypropoxy)phenyl]amino]carbonyl]ethyl]dimethylsulfonium
[2-[4-(2-Hydroxy-3-ethoxypropoxy)phenylcarbamoyl]ethyl]dimethylsulfonium
[3-Oxo-3-[4-(2-hydroxy-3-ethoxypropoxy)phenylamino]propyl]dimethylsulfonium
2-[4-(2-Hydroxy-3-ethoxypropoxy)phenylcarbamoyl]ethyldimethylsulfonium
N-[4-(2-Hydroxy-3-ethoxypropoxy)phenyl]-3-(dimethylsulfonio)propanamide
SUPLATAST TOSILATE
Suplatast tosylate
[3-[[4-(3-Ethoxy-2-hydroxypropoxy)phenyl]amino]-3-oxopropyl]dimethylsulfonium4-methylbenzenesulfonate
Suplatast
[3-[[4-(3-ethoxy-2-hydroxypropoxy)phenyl]amino]-3-oxopropyl]dimethyl-sulfonium, 4-methylbenzenesulfonate (1:1)
N,N-dimethyl-2-propyl-1-pentanamine
Suplatast Tosylate >
High quality USP 39/EP 9.0 /BP 2012 GMP DMF FDA Suplatast tosilate CAS NO 18472-51-0 producer
Suplatast tosilate USP/EP/BP
Suplatast Tosylate (IPD 1151T)
TIANFU CHEM--Suplatast tosilate
3-[[4-(3-Ethoxy-2-hydroxypropoxy)phenyl]amino]-3-oxopropyl]dimethyl
Methotrexate Impurity 47
94055-76-2
C16H26NO4SC7H7O3S
C16H26NO4SC7H7O3SC23H
C16H26NO4SC7H7O3SC23H33NO7S2
C23H33NO7S2
API
Aromatics
Inhibitors
Intermediates & Fine Chemicals
Pharmaceuticals
Sulfur & Selenium Compounds
IPD 1151T