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SU 6668

SU 6668 Structure
CAS No.
210644-62-5
Chemical Name:
SU 6668
Synonyms
SU 6668;(Z)-SU6668;(Z)-TSU-68;(Z)-Orantinib;(Z)-Orantinib/SU6668/TSU-68);PDGFR Tyrosine Kinase Inhibitor VI, SU6668;PDGFR Tyrosine Kinase Inhibitor VI, SU6668 - CAS 210644-62-5 - Calbiochem;3-[2,4-dimethyl-5-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoicacid;3-(2,4-Dimethyl-5-{[(3Z)-2-oxo-1H-indol-3-ylidene]methyl}-1H-pyrrol-3-yl)propanoic acid;3-(2,4-Dimethyl-5-(2-oxo-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrol-3-yl)-propionic acid
CBNumber:
CB91312244
Molecular Formula:
C18H18N2O3
Molecular Weight:
310.35
MOL File:
210644-62-5.mol
Modify Date:
2024/7/2 8:55:40
Request For Quotation

SU 6668 Properties

storage temp. +2C to +8C
solubility DMSO : 50 mg/mL (161.11 mM; Need ultrasonic)
form Dark yellow solid
color Orange to red

SU 6668 price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) CDS023028 2,4-Dimethyl-5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-pyrrole-3-propanoic acid 210644-62-5 100MG ₹27787.78 2022-06-14 Buy
Product number Packaging Price Buy
CDS023028 100MG ₹27787.78 Buy

SU 6668 Chemical Properties,Uses,Production

Uses

PDGFR Tyrosine Kinase Inhibitor VI, SU6668 is a potent ATP-competitive inhibitor against tyrosine kinases.

General Description

A cell-permeable indolinone compound that acts as a potent ATP-competitive inhibitor against RTKs (receptor tyrosine kinases) Kit, PDGFRβ, VEGFR2 (Flk-1/KDR), FGFR1 activity in vitro (IC50 = 0.01, 0.1, 3.9, and 3.8 μM, respectively) and PDGF/VEGF/bFGF-mediated angiogenesis and tumor development in vivo. Although initially characterized as an RTK inhibitor, SU6668 is now also known to target ser/thr kinases Aurora A, Aurora B, TBK1 (NAK/T2K), and AMPK (IC50 = 0.85, 0.047, 1.4, and 1.8 μM, respectively), as well as non-receptor TKs Lyn and Yes (IC50 = 4.3 and 5.8 μM, respectively).

SU 6668 Preparation Products And Raw materials

Raw materials

Preparation Products

SU 6668 Suppliers

Global( 49)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Baoji Guokang Healthchem co.,ltd +8615604608665 15604608665 CHINA 9427 58 Inquiry
Shaoxin Catsyn Co., Ltd. +undefined-0575-82040869 +86-0575-82040869; China 6116 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 52927 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
Matrix Scientific 803 788-9494 All other calls United States 6655 80 Inquiry
Shanghai Jizhi Biochemical Technology Co. Ltd. 400-400-400-9004166 18616739031 China 52712 58 Inquiry
Riedel-de Haen AG 800 558-9160 United States 6825 87 Inquiry
Sigma-Aldrich 021-61415566 800-8193336 China 51471 80 Inquiry
Beijing Shengke Boyuan Biotechnology Co., Ltd. 010-62968438 CHINA 6011 58 Inquiry
Supplier Advantage
A.J Chemicals 58
Baoji Guokang Healthchem co.,ltd 58
Shaoxin Catsyn Co., Ltd. 58
Aladdin Scientific 58
Amadis Chemical Company Limited 58
Matrix Scientific 80
Shanghai Jizhi Biochemical Technology Co. Ltd. 58
Riedel-de Haen AG 87
Sigma-Aldrich 80
Beijing Shengke Boyuan Biotechnology Co., Ltd. 58

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SU 6668 3-(2,4-Dimethyl-5-(2-oxo-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrol-3-yl)-propionic acid 1H-Pyrrole-3-propanoic acid, 5-((Z)-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl- 5-((Z)-1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-propanoic acid PDGFR Tyrosine Kinase Inhibitor VI, SU6668 3-[2,4-dimethyl-5-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoicacid PDGFR Tyrosine Kinase Inhibitor VI, SU6668 - CAS 210644-62-5 - Calbiochem 3-(2,4-Dimethyl-5-{[(3Z)-2-oxo-1H-indol-3-ylidene]methyl}-1H-pyrrol-3-yl)propanoic acid (Z)?-?3-?(2,?4-?Dimethyl-?5-?((2-?oxoindolin-?3-?ylidene)?methyl)?-?1H-?pyrrol-?3-?yl)?propanoic acid (SU-6668) (Z)-Orantinib (Z)-SU6668 (Z)-TSU-68 5-(Z)-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl-2,4-dimethyl-1H-pyrrol-3-propanoic acid (Z)-Orantinib/SU6668/TSU-68) 210644-62-5