SU 6668
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- ₹27787.78
- Product name: SU 6668
- CAS: 210644-62-5
- MF: C18H18N2O3
- MW: 310.35
- EINECS:
- MDL Number:MFCD09743433
- Synonyms:SU 6668;3-(2,4-Dimethyl-5-(2-oxo-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrol-3-yl)-propionic acid;1H-Pyrrole-3-propanoic acid, 5-((Z)-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-;5-((Z)-1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-propanoic acid;PDGFR Tyrosine Kinase Inhibitor VI, SU6668;3-[2,4-dimethyl-5-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoicacid;PDGFR Tyrosine Kinase Inhibitor VI, SU6668 - CAS 210644-62-5 - Calbiochem;3-(2,4-Dimethyl-5-{[(3Z)-2-oxo-1H-indol-3-ylidene]methyl}-1H-pyrrol-3-yl)propanoic acid
1 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 100MG
- ManufacturerSigma-Aldrich(India)
- Product numberCDS023028
- Product description2,4-Dimethyl-5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-pyrrole-3-propanoic acid
- Packaging100MG
- Price₹27787.78
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | CDS023028 | 2,4-Dimethyl-5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-pyrrole-3-propanoic acid | 100MG | ₹27787.78 | 2022-06-14 | Buy |
Properties
storage temp. :+2C to +8C
solubility :DMSO : 50 mg/mL (161.11 mM; Need ultrasonic)
form :Dark yellow solid
color :Orange to red
solubility :DMSO : 50 mg/mL (161.11 mM; Need ultrasonic)
form :Dark yellow solid
color :Orange to red
Safety Information
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Description
PDGFR Tyrosine Kinase Inhibitor VI, SU6668 is a cell-permeable indolinone compound that acts as a potent ATP-competitive inhibitor against RTKs (receptor tyrosine kinases) Kit, PDGFRβ, VEGFR2 (Flk-1/KDR), FGFR1 activity in vitro (IC50 = 0.01, 0.1, 3.9, and 3.8 M, respectively) and PDGF/VEGF/bFGF-mediated angiogenesis and tumor development. Although initially characterized as an RTK inhibitor, SU6668 is now also known to target ser/thr kinases Aurora A, Aurora B, TBK1 (NAK/T2K), and AMPK (IC50 = 0.85, 0.047, 1.4, and 1.8 M, respectively), as well as non-receptor TKs Lyn and Yes (IC50 = 4.3 and 5.8 M, respectively).More related product prices
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