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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Neuronal Signaling >COX inhibitors >Licofelone

Licofelone

Licofelone Structure
CAS No.
156897-06-2
Chemical Name:
Licofelone
Synonyms
icofeL;ML 3000;Licofelone;Licofelone, >=99%;Licofelone, ML-3000;Licofelone USP/EP/BP;16-dihydrotanshinone I;Licofelone, 10 mM in DMSO;2-[2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-5,7-dihydropyrrolizin-3-yl]acetic acid;1H-Pyrrolizine-5-aceticacid, 6-(4-chlorophenyl)-2,3-dihydro-2,2-diMethyl-7-phenyl-
CBNumber:
CB91385206
Molecular Formula:
C23H22ClNO2
Molecular Weight:
379.88
MOL File:
156897-06-2.mol
MSDS File:
SDS
Modify Date:
2024/11/19 15:53:33
Request For Quotation

Licofelone Properties

Melting point 162-163°C
Boiling point 539.7±50.0 °C(Predicted)
Density 1.23
storage temp. -20°C Freezer
solubility Chloroform, Methanol
pka 4.47±0.10(Predicted)
form Solid
color Off-White to Light Yellow
CAS DataBase Reference 156897-06-2(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H319
Precautionary statements  P305+P351+P338

Licofelone Chemical Properties,Uses,Production

Description

Cross-talk between lipoxygenase (LO) and cyclooxygenase (COX) pathways has been observed in human osteoarthritic synovial explants which creates an arachidonic acid shunting phenomenon, stimulating interleukin-1β (IL-1β) synthesis. Licofelone is a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LO) pathways, that decreases levels of prostaglandin E2, leukotriene B4, and lipoxins and prevents lipopolysaccharide-stimulated IL-1β expression. The IC50 values for inhibition of human thrombocyte COX and human 5-LO are 0.16 μM and 0.23 μM, respectively. Unlike other non-steroidal anti-inflammatory drugs, licofelone causes little or no damage to the gastric mucosa in rabbit parietal cells. This is presumably the result of licofelone’s affects on acid-secretory mechanisms, mediated by the inhibition of 5-LO activity.

Chemical Properties

Yellowish Solid

Licofelone Preparation Products And Raw materials

Raw materials

Preparation Products

Licofelone Suppliers

Global( 132)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6739 58 Inquiry
Henan Tianfu Chemical Co.,Ltd. +86-0371-55170693 +86-19937530512 China 21628 55 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49732 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29808 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 32222 58 Inquiry
Hubei Ipure Biology Co., Ltd +8613367258412 China 10244 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 22855 58 Inquiry
AFINE CHEMICALS LIMITED +86-0571-85134551 China 15417 58 Inquiry
Finetech Industry Limited +86-27-8746-5837 +8619945049750 China 9642 58 Inquiry
Hefei TNJ Chemical Industry Co.,Ltd. +86-0551-65418684 +8618949823763 China 25356 58 Inquiry
Supplier Advantage
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Henan Tianfu Chemical Co.,Ltd. 55
CONIER CHEM AND PHARMA LIMITED 58
career henan chemical co 58
TargetMol Chemicals Inc. 58
Hubei Ipure Biology Co., Ltd 58
Dideu Industries Group Limited 58
AFINE CHEMICALS LIMITED 58
Finetech Industry Limited 58
Hefei TNJ Chemical Industry Co.,Ltd. 58

Licofelone Spectrum

Licofelone(156897-06-2)1HNMR

156897-06-2(Licofelone)Related Search:

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METHYL-2-PYRROLIDONE 1-METHYL-PYRROLE-2-ACETIC ACID 2,5-DIMETHYL-1-PROPYL-1H-PYRROLE
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2-[6-(4-Chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid Licofelone, ML-3000 [2,2-Dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid ML 3000 2-[2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-5,7-dihydropyrrolizin-3-yl]acetic acid Licofelone 6-(4-Chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl- 1H-pyrrolizine-5-acetic Acid 1H-Pyrrolizine-5-aceticacid, 6-(4-chlorophenyl)-2,3-dihydro-2,2-diMethyl-7-phenyl- Licofelone, >=99% icofeL Licofelone USP/EP/BP 16-dihydrotanshinone I Licofelone, 10 mM in DMSO 156897-06-2 C23H22ClNO2 Intermediates & Fine Chemicals Pharmaceuticals Inhibitors