4-Butylresorcinol
- CAS No.
- 18979-61-8
- Chemical Name:
- 4-Butylresorcinol
- Synonyms
- Butylresorcinol;4-N-BUTYLRESORCINOL;4-Butylbenzene-1,3-diol;2,4-DIHYDROXY-N-BUTYL BENZEN;Rucinol;N-BUTYLRESEOCINOL;4-Butylresorcinol;Serine Impurity 12;Resorcinol, 4-butyl-;4-Butylresorcinol >
- CBNumber:
- CB9361328
- Molecular Formula:
- C10H14O2
- Molecular Weight:
- 166.22
- MOL File:
- 18979-61-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/7 19:09:42
| Melting point | 50.0 to 55.0 °C |
|---|---|
| Boiling point | 166°C/7mmHg(lit.) |
| Density | 1.092±0.06 g/cm3(Predicted) |
| vapor pressure | 0.041Pa at 25℃ |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO : 150 mg/mL (902.42 mM) |
| form | Powder |
| pka | 9.95±0.18(Predicted) |
| color | white to pale yellow powder |
| Odor | Characteristic |
| InChI | InChI=1S/C10H14O2/c1-2-3-4-8-5-6-9(11)7-10(8)12/h5-7,11-12H,2-4H2,1H3 |
| InChIKey | CSHZYWUPJWVTMQ-UHFFFAOYSA-N |
| SMILES | C1(O)=CC=C(CCCC)C(O)=C1 |
| LogP | 2.8 at 24℃ and pH7 |
| Surface tension | 17.8mN/m at 1g/L and 20℃ |
| CAS DataBase Reference | 18979-61-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P312+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P501 | |||||||||
| RTECS | VH0420000 | |||||||||
| HS Code | 2907290090 | |||||||||
| NFPA 704 |
|
4-Butylresorcinol Chemical Properties,Uses,Production
Description
4-n-butylresorcinol is a derivative of resorcinol and a potent human tyrosinase inhibitor. It may be used to decrease skin irritation and is also known to inhibit melanin production.
Uses
4-Butylresorcinol is considered a potential Cytochrome P450 inhibitor. It can cause hypopigmentation due to its direct inhibition of tyrosinase.
Application
Glycerol is used both in sample preparation and gel formation for polyacrylamide gel electrophoresis. Glycerol (5-10%) increases the density of a sample so that the sample will layer at the bottom of a gel′s sample well. Glycerol is also used to aid in casting gradient gels and as a protein stabilizer and storage buffer component.
Biological Activity
Glutathione reductase IGR) is a crucial flavoenzyme in the antioxidant defense system. Reduced glutathione (GSH) is used by glutathione peroxidase to detoxify hydrogen peroxide and in the process is converted to oxidized glutathione (GSSG). The GSSG is then recycled back to GSH by glutathione reductase (GR) using NADPH that is then converted to NADP+. The regenerated GSH is then available to detoxify more hydrogen peroxide. The enzyme uses FAD as a cofactor. GR and glutathione peroxidase may inhibit lipid peroxidation by functioning as antioxidant enzymes in sperm. Glutathione reductase shares a structural motif with a number of other proteins including aspartyl proteases, citrate synthase, EF hands, hemoglobins, lipocalins, and α/β hydrolases. GR is stimulated by melatonin and is reportedly irreversibly inhibited by a number of oxygen radical generating systems.A sweet tastant for mammals. A glycerol taste receptor binding site specific for glucose has been proposed in drosophila.
Mechanism of action
The mechanism of action of 4-butylresorcinol depigmentation is through inhibition of tyrosinase and tyrosinase-related protein-1 (TRP-1)[1].
References
[1] D. RESENDE. Skin Depigmenting Agents in Anti-Aging Cosmetics: A Medicinal Perspective on Emerging Ingredients[J]. Applied Sciences-Basel, 2022. DOI:10.3390/app12020775.
4-Butylresorcinol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| BTC pharm India | +918790379245 | AndhraPradesh, India | 1269 | 58 | Inquiry |
| KROMOZOME | +91-91-9650900955 +91-09650900955 | Maharashtra, India | 71 | 58 | Inquiry |
| R SCIENTIFIC | +919000280374 | Hyderabad, India | 143 | 58 | Inquiry |
| SNECOFRi Pvt Ltd | +91-9032850129 +91-9032850129 | Telangana, India | 404 | 58 | Inquiry |
| Salicylates and Chemicals Pvt. Ltd. | +91-8879630551 +91-8898005838 | Maharashtra, India | 61 | 58 | Inquiry |
| Navitus Chemicals Pvt Ltd | +91-9370559385 +91-9370559385 | Maharashtra, India | 25 | 58 | Inquiry |
| Mekong pharmaceuticals pvt ltd | +91-4035163894 +91-8008212221 | Telangana, India | 129 | 58 | Inquiry |
| Innovassynth Technologies (I) Ltd. | +91-2192260100 +91-7208872197 | Maharashtra, India | 118 | 58 | Inquiry |
| Gravitas Pharma Pvt Ltd | +91-9177758787 +91-9177758787 | Hyderabad, India | 103 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| BTC pharm India | 58 |
| KROMOZOME | 58 |
| R SCIENTIFIC | 58 |
| SNECOFRi Pvt Ltd | 58 |
| Salicylates and Chemicals Pvt. Ltd. | 58 |
| Navitus Chemicals Pvt Ltd | 58 |
| Mekong pharmaceuticals pvt ltd | 58 |
| Innovassynth Technologies (I) Ltd. | 58 |
| Gravitas Pharma Pvt Ltd | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
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Related Qustion
- Q:Is 4-Butylresorcinol safe in the treatment of melasma?
- A:4-Butylresorcinol 0.1% Cream has shown rapid efficacy and good tolerability when used in the treatment of melasma.
- Jan 3，2024
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