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Salirasib

Salirasib Structure
CAS No.
162520-00-5
Chemical Name:
Salirasib
Synonyms
FTS;irasib;CS-1744;Salirasib;Unii-mzh0om550m;Salirasib USP/EP/BP;Farnesylthiosalicylate;FARNESYLTHIOSALICYLIC ACID;S-Farnesylthiosalicylic acid;Salirasib(S-Farnesylthiosalicylic aci)
CBNumber:
CB9694198
Molecular Formula:
C22H30O2S
Molecular Weight:
358.54
MOL File:
162520-00-5.mol
MSDS File:
SDS
Modify Date:
2023/6/8 17:06:36

Salirasib Properties

Melting point 64-66°C
Boiling point 486.0±45.0 °C(Predicted)
Density 1.05
storage temp. -20°C
solubility DMSO: soluble20mg/mL, clear
pka 3.50±0.36(Predicted)
form powder
color white to beige
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H319-H315
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
HS Code  2930.90.2900
NFPA 704
0
2 0

Salirasib price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SML1166 Salirasib ≥98% (HPLC) 162520-00-5 10MG ₹8086.28 2022-06-14 Buy
Sigma-Aldrich(India) SML1166 Salirasib ≥98% (HPLC) 162520-00-5 50MG ₹32680.68 2022-06-14 Buy
TCI Chemicals (India) A3351 Salirasib 162520-00-5 25MG ₹4800 2022-05-26 Buy
TCI Chemicals (India) A3351 Salirasib 162520-00-5 100MG ₹16300 2022-05-26 Buy
Product number Packaging Price Buy
SML1166 10MG ₹8086.28 Buy
SML1166 50MG ₹32680.68 Buy
A3351 25MG ₹4800 Buy
A3351 100MG ₹16300 Buy

Salirasib Chemical Properties,Uses,Production

Description

Association of Ras protein with the inner surface of the plasma membrane is required for Ras signaling activity. Farnesyl thiosalicylic acid (FTS) is an inhibitor of Ras-mediated signaling that functions by dislodging Ras from the cell membrane thereby rendering it susceptible to proteolytic degradation. FTS inhibits the growth of human Ha-ras-transformed Rat1 fibroblasts with an IC50 value of 7.5 μM. It does not inhibit Ras farnesylation in vitro and although FTS does inhibit prenylated protein methyltransferase (PPMTase) in cell-free systems with a Ki value of 2.6 μM, it is relatively ineffective at inhibiting methylation in whole cells. Treatment of chow-fed ApoE-deficient mice with 5 mg/kg FTS three times per week for six weeks reduces early atherosclerotic lesion development by 52% compared to controls.

Chemical Properties

Pale Yellow Solid

Uses

Salirasib is a new specific nontoxic drug with a mild hydrophobic nature, which acts as a Ras antagonist and can therefore be used for stent applications as well as for local cancer treatment.

Salirasib Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 120)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6778 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
SHANGHAI T&W PHARMACEUTICAL CO., LTD. +86-021-61551413 +8618813727289 China 5738 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 26368 58 Inquiry
Baoji Guokang Bio-Technology Co., Ltd. 0917-3909592 13892490616 China 9327 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry

Salirasib Spectrum

FARNESYLTHIOSALICYLIC ACID FTS Unii-mzh0om550m (3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL)-2-THIOBENZOIC ACID 2-[[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-yl]thio]benzoic acid Farnesylthiosalicylate Salirasib S-Farnesylthiosalicylic acid (E,E)-2-[(3,7,11-TriMethyl-2,6,10-dodecatrienyl)thio]benzoic Acid S-trans,trans-Farnesylthiosalicylic acid 2-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienylthio)benzoic acid 2-(((2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-yl)thio)benzoicacid CS-1744 Salirasib(S-Farnesylthiosalicylic aci) irasib Benzoic acid, 2-[[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]thio]- Salirasib USP/EP/BP Salirasib (Farnesyl Thiosalicylic Acid) 162520-00-5 Aromatics Inhibitors Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds API