XL518
XL518
- CAS:
- 934660-93-2
- MF:
- C21H21F3IN3O2
- MW:
- 531.31
Suppliers by country/region
Company Type
Properties
- Melting point:
- 165 - 166°C
- Boiling point:
- 565.9±50.0 °C(Predicted)
- Density
- 1.706
- storage temp.
- Refrigerator
- solubility
- Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 13.13±0.20(Predicted)
- color
- Off-White
Safety Information
Use
A potent, selective, orally bioavailable inhibitor of MEK1, a component of the RAS/RAF/MEK/ERK pathway. It inhibits proliferation and stimulates apoptosis in a variety of human tumor cell lines. In preclinical xenograft models, oral administration of XL518 results in sustained inhibition of pERK in tumor tissue, but not brain tissue, leading to tumor growth inhibition and regression at well tolerated doses.
1 India supplier list of "XL518"
- Product Name:XL518
- Products Intro:Brand:clearsynth | Product Number:CS-T-46637
- Company Type: Trader
- Country/Region: Hyderabad,INDIA
- Product Name:Cobimetinib
- Products Intro:Brand:synzeal | Product Number:172924985
- Company Type: Trader
- Country/Region: Gujarat,INDIA
- Product Name:XL518
- Company Type: Reagent
- Country/Region: Haryana,INDIA
- Product Name:Cobimetinib
- Products Intro:Brand:ajchemicals | Product Number:JDH-27795 | Purity:98+%
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:Cobimetinib
- Products Intro:Brand:pharmaffiliates | Product Number:PA5664000
- Company Type: Trader
- Country/Region: Haryana,INDIA
- Product Name:Cobimetinib
- Products Intro:Purity: As coa | Package: As request | CustNote: 934660-93-2
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Cobimetinib
- Products Intro:Purity: 98+% | Package: 25g;50g;100g;500g;1kg;10kg;50kg
- Company Type: Reagent
- Country/Region: CHINA
- Product Name:Cobimetinib
- Products Intro:Purity: >=98% | Package: 25mg | CustNote: BOC Sciences also provides custom synthesis services for Cobimetinib.
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:XL518
- Products Intro:Purity: 0.98 | Package: 1kg，2kg，5kg，10kg，25kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 2,7-ADA,2,4,6-Trichloroaniline,TRIMETHYLOXONIUM TETRAFLUOROBORATE,Zinc sulfide,5-HEXEN-1-OL