9-keto Fluprostenol isopropyl ester
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- ₹0
- Product name: 9-keto Fluprostenol isopropyl ester
- CAS: 1219032-18-4
- MF: C26H33F3O6
- MW: 498.53
- EINECS:
- MDL Number:MFCD02259341
- Synonyms:(+)-9-OXO-11ALPHA,15R-DIHYDROXY-16-(3-(TRIFLUOROMETHYL)PHENOXY)-17,18,19,20-TETRANOR-PROSTA-5Z,13E-DIEN-1-OIC-ACID, ISOPROPYL ESTER;9-KETO FLUPROSTENOL ISOPROPYL ESTER;FLUPROSTENOL PROSTAGLANDIN E2 ISOPROPYL ESTER;Travoprost Impurity 16(9-keto Fluprostenol Isopropyl Ester);9-Keto Travoprost;Travoprost Impurity 35;Travoprost Impurity 21;Travoprost 12
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Properties
Boiling point :583.6±50.0 °C(Predicted)
Density :1.241±0.06 g/cm3(Predicted)
solubility :DMF: 30 mg/ml; DMF:PBS (1:1): 500 μg/ml; DMSO: 20 mg/ml; Ethanol: 25 mg/ml
pka :13.32±0.20(Predicted)
Density :1.241±0.06 g/cm3(Predicted)
solubility :DMF: 30 mg/ml; DMF:PBS (1:1): 500 μg/ml; DMSO: 20 mg/ml; Ethanol: 25 mg/ml
pka :13.32±0.20(Predicted)
Safety Information
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Description
Fluprostenol is a well-studied, potent analog of prostaglandin F2α (PGF2α) and acts primarily through the FP receptor. Oxidation at C-9 of fluprostenol yields 9-keto fluprostenol. Prostaglandin esters are known to be hydrolyzed in the eye to the corresponding free acids. However, the use of prostaglandin esters as prodrugs outside the eye is relatively unexplored. 9-keto Fluprostenol is an analog of PGE2 with structural modifications intended to give it a prolonged half-life and greater potency. 9-keto Fluprostenol isopropyl ester has the potential to act as an EP agonist in prodrug form. However, no studies on the pharmacology of this compound have been published to date. In addition 9-keto fluprostenol isopropyl ester is a potential metabolite of Travoprost, which is the Alcon trade name for fluprostenol isopropyl ester. In monkey cornea, this transformation was observed as a product of NADP+-dependent 15-hydroxyprostaglandin dehydrogenase when the closely related analog Latanoprost was used as a substrate. Certain F-series prostaglandins have been shown to be converted to the corresponding E-series compounds in rabbit liver and human platelet preparations.More related product prices
9-KETO FLUPROSTENOL 15(S)-FLUPROSTENOL (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]-N-(1,3-dihydroxypropan-2-yl)hept-5-enamide Travoprost Acid 404830-45-1 3-Trifluoromethylphenol 5,6-trans Travoprost 15-KETO FLUPROSTENOL Travoprost 1420791-14-5 Ethyl bromoacetate IodoethaneRelated product price
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₹1134-11100 - Travoprost
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₹1206-38266
Suppliers and manufacturers
Pharmaffiliates Analytics and Synthetics P. Ltd
China National Standard Pharmaceutical Corporation Limited
Cayman Chemical Company
Shanghai Yifei Biotechnology Co. , Ltd.
TOSUN PHARM
Hubei Qingbei Yunyan Pharmaceutical Technology Co., Ltd
Hubei Yangxin Medical Technology Co., Ltd.
Nantong Hanfang Biotechnology Co. , Ltd.
Scinova Biotech(Guangzhou) Co., Ltd.
ChemStrong Scientific Co.,Ltd