(Z,E)-5-(4-ETHYLBENZYLIDINE)-2-THIOXOTHIAZOLIDIN-4-ONE
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- ₹6900 - ₹30504.85
- Product name: (Z,E)-5-(4-ETHYLBENZYLIDINE)-2-THIOXOTHIAZOLIDIN-4-ONE
- CAS: 403811-55-2
- MF: C12H11NOS2
- MW: 249.35
- EINECS:
- MDL Number:MFCD00758517
- Synonyms:(5E)-5-[(4-ethylphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one;c-Myc Inhibitor;ZINC01085340;(Z,E)-5-(4-ETHYLBENZYLIDINE)-2-THIOXOTHIAZOLIDIN-4-ONE;10058-F4;5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone;(5E)-5-(4-ethylbenzylidene)-2-mercapto-1,3-thiazol-4(5H)-one;Albb-009118
5 prices
Selected condition：
Brand
- ALFA India
- TCI Chemicals (India)
- Sigma-Aldrich(India)
Package
- 5MG
- 10mg
- 25MG
- ManufacturerALFA India
- Product numberALF-J65650-MA
- Product description10058-F4
- Packaging10mg
- Price₹15205
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberE0959
- Product description5-(4-Ethylbenzylidene)rhodanine
- Packaging25MG
- Price₹6900
- Updated2022-05-26
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberF3680
- Product description10058-F4 ≥98% (HPLC), solid
- Packaging5MG
- Price₹7718.23
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number475956
- Product descriptionc-Myc Inhibitor - CAS 403811-55-2 - Calbiochem The c-Myc Inhibitor, also referenced under CAS 403811-55-2, controls the biological activity of c-Myc.
- Packaging10MG
- Price₹16670.01
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberF3680
- Product description10058-F4 ≥98% (HPLC), solid
- Packaging25MG
- Price₹30504.85
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| ALFA India | ALF-J65650-MA | 10058-F4 | 10mg | ₹15205 | 2022-05-26 | Buy |
| TCI Chemicals (India) | E0959 | 5-(4-Ethylbenzylidene)rhodanine | 25MG | ₹6900 | 2022-05-26 | Buy |
| Sigma-Aldrich(India) | F3680 | 10058-F4 ≥98% (HPLC), solid | 5MG | ₹7718.23 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 475956 | c-Myc Inhibitor - CAS 403811-55-2 - Calbiochem The c-Myc Inhibitor, also referenced under CAS 403811-55-2, controls the biological activity of c-Myc. | 10MG | ₹16670.01 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | F3680 | 10058-F4 ≥98% (HPLC), solid | 25MG | ₹30504.85 | 2022-06-14 | Buy |
Properties
Density :1.33±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >10mg/mL
form :Yellow solid
pka :7.72±0.30(Predicted)
color :yellow
Water Solubility :Soluble in DMSO. Soluble in water at concentrations less than 2mg/ml
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
storage temp. :2-8°C
solubility :DMSO: >10mg/mL
form :Yellow solid
pka :7.72±0.30(Predicted)
color :yellow
Water Solubility :Soluble in DMSO. Soluble in water at concentrations less than 2mg/ml
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
The Myc proto-oncogenes interact with Max to form a dimer that regulates gene transcription. The protein c-Myc, in particular, promotes gene expression relevant to cell growth and thus drives cancer. 10058-F4 is a cell-permeable thiazolidinone that inhibits the dimerization of c-Myc and Max at 64 μM, preventing c-Myc-dependent gene expression and cell proliferation. It induces cell cycle arrest, apoptosis, and myeloid differentiation at 100 μM in human acute myeloid leukemia cells. 10058-F4 is rapidly metabolized in mice when given intravenously, limiting its effects on tumors in vivo. In addition to c-Myc, 10058-F4 inhibits the nuclear Myc protein, N-Myc, at 50 μM, inducing arrest, apoptosis, and differentiation in neuroblastoma cells overexpressing the gene for N-Myc. This compound can be used to delineate novel actions of Myc proteins, especially those related to lipid and glucose metabolism.More related product prices
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