Insulin-like Growth Factor-1 Receptor Inhibitor
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- Product name: Insulin-like Growth Factor-1 Receptor Inhibitor
- CAS: 468740-43-4
- MF: C25H26ClN5O3
- MW: 479.96
- EINECS:
- MDL Number:MFCD14635360
- Synonyms:4-[[(2S)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]-3-[7-methyl-5-(4-morpholinyl)-1H-benzimidazol-2-yl]-2(1H)-pyridinone;BMS-536924;Insulin-like Growth Factor-1 Receptor Inhibitor;4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-[4-methyl-6-(4-morpholinyl)-1H-benzimidazol-2-yl]- 2(1H)-pyridinone;CS-0117;HY-10262;BMS-536924 Insulin-like Growth Factor-1 Receptor Inhibitor;BMS-536924, >=98%
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Properties
Melting point :>206°C (dec.)
Density :1.44
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :DMSO (Slightly)
pka :10.40±0.10(Predicted)
form :Solid
color :Light Yellow to Yellow
CAS DataBase Reference :468740-43-4
Density :1.44
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :DMSO (Slightly)
pka :10.40±0.10(Predicted)
form :Solid
color :Light Yellow to Yellow
CAS DataBase Reference :468740-43-4
Safety Information
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Description
BMS-536924 is a dual inhibitor of insulin-like growth factor receptor (IGF1R) kinase and insulin receptor (IC50s = 100 and 73 nM, respectively). In this way, it blocks IGF1R autophosphorylation and signaling through MEK1/2 and Akt, leading to G1 arrest and apoptosis in myeloblastic leukemia ML-1 cells. BMS-536924 reverses epithelial-to-mesenchymal transition in immortalized mammary epithelial MCF10A cells overexpressing constitutively activated IGF1R and causes growth inhibition and polarization of breast cancer MCF-7 cells. It also induces expression of cytochrome P450 3A4 isoform in primary hepatocytes.Related product price
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