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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Apoptosis >Mdm2 activator >4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide

4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide

4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide Structure
  • ₹0
  • Product name: 4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide
  • CAS: 58131-57-0
  • MF: C11H13N5O4
  • MW: 279.25
  • EINECS:200-258-5
  • MDL Number:MFCD01908645
  • Synonyms:4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazan 3-oxide;4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide;7-(4-Methyl-1-piperazinyl)-4-nitrobenzofurazane 1-oxide;XI-006 (NSC207895)=1119;NSC-207895;NSC-207895 (XI-006);NSC 179940;4-(4-Methyl-1-piperazinyl)-7-nitro-2,1,3-benzoxadiazole 3-oxide
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Boiling point :487.6±55.0 °C(Predicted)
Density :1.64
storage temp. :Store at -20°C
solubility :Limited solubility
form :Powder
pka :6.23±0.42(Predicted)
color :Brown to reddish brown

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning GHS hazard pictograms P261, P271, P304+P340, P312
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

NSC 207895 is an inhibitor of the p53-binding protein MDMX. It decreases MDMX promoter activity in a reporter assay using HT-1080 cells in a concentration-dependent manner. NSC 207895 (5 μmol/L) decreases the expression and protein levels of MDMX and increases the expression of the p53 target gene CDKN1 (p21) in MCF-7 cells overexpressing MDMX. It also increases the expression of the pro-apoptotic genes PUMA, Bax, and PIG3. NSC 207895 (5 μmol/L) induces apoptosis and decreases cell viability in MCF-7 cells in a p53-dependent manner. It also induces p53-independent apoptosis in wild-type, mutated, and truncated p53 Ewing sarcoma cell lines (IC50s = 98.9-1,613, 236-299, and 121-396 nM, respectively) selectively over wild-type and p53-null osteosarcoma cells (IC50s = 3,690-5,416 and 2,143 nM, respectively).

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Suppliers and manufacturers

career henan chemical co
4-(4-Methyl-1-piperazinyl)-7-nitro-2,1,3-benzoxadiazole 3-oxide
₹1.00 /1g
4-(4-Methyl-1-piperazinyl)-7-nitro-2,1,3-benzoxadiazole 3-oxide CAS:58131-57-0
ATK CHEMICAL COMPANY LIMITED
Dideu Industries Group Limited
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
TargetMol Chemicals Inc.
Wuhan Topule Biopharmaceutical Co., Ltd
LEAPCHEM CO., LTD.
Aladdin Scientific
Amadis Chemical Company Limited