Phenoxybenzamine hydrochloride
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- ₹4800 - ₹14600
- Product name: Phenoxybenzamine hydrochloride
- CAS: 63-92-3
- MF: C18H22ClNO.ClH
- MW: 340.29
- EINECS:200-569-7
- MDL Number:MFCD00055152
- Synonyms:benzyl(2-chloroethyl)(1-methyl-2-phenoxyethyl)aminehydrochloride ;dibenzyran ;n-phenoxyisopropyl-n-benzyl-beta-chloroethylaminehydrochloride ;phenoxybenzamidehydrochloride ;BENZENE METHANAMINE HYDROCHLORIDE;DIBENZYLINE HYDROCHLORIDE;N-PHENOXYISOPROPYL-N-BENZYL-2-CHLOROETHYLAMINE HYDROCHLORIDE;PHENOXYBENZAMINE HYDROCHLORIDE
4 prices
Selected condition：
Brand
- TCI Chemicals (India)
- Sigma-Aldrich(India)
Package
- 250MG
- 1G
- 25G
- ManufacturerTCI Chemicals (India)
- Product numberD0158
- Product descriptionPhenoxybenzamine Hydrochloride
- Packaging1G
- Price₹4800
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberD0158
- Product descriptionPhenoxybenzamine Hydrochloride
- Packaging25G
- Price₹14600
- Updated2022-05-26
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberB019
- Product descriptionPhenoxybenzamine hydrochloride ≥97%, powder
- Packaging250MG
- Price₹14094.15
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberPHR1402
- Product descriptionPhenoxybenzamine Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging1G
- Price₹8270.3
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| TCI Chemicals (India) | D0158 | Phenoxybenzamine Hydrochloride | 1G | ₹4800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | D0158 | Phenoxybenzamine Hydrochloride | 25G | ₹14600 | 2022-05-26 | Buy |
| Sigma-Aldrich(India) | B019 | Phenoxybenzamine hydrochloride ≥97%, powder | 250MG | ₹14094.15 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1402 | Phenoxybenzamine Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material | 1G | ₹8270.3 | 2022-06-14 | Buy |
Properties
Melting point :137.5°C
storage temp. :15-25°C
solubility :soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF).
form :powder
pka :pKa 4.4 (Uncertain)
color :white
Water Solubility :<0.01 g/100 mL at 18.5 ºC
Merck :14,7256
Stability :Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
CAS DataBase Reference :63-92-3(CAS DataBase Reference)
IARC :2B (Vol. 24, Sup 7) 1987
EPA Substance Registry System :N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine hydrochloride (63-92-3)
storage temp. :15-25°C
solubility :soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF).
form :powder
pka :pKa 4.4 (Uncertain)
color :white
Water Solubility :<0.01 g/100 mL at 18.5 ºC
Merck :14,7256
Stability :Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
CAS DataBase Reference :63-92-3(CAS DataBase Reference)
IARC :2B (Vol. 24, Sup 7) 1987
EPA Substance Registry System :N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine hydrochloride (63-92-3)
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
Phenoxybenzamine is a noncompetitive, irreversible α-adrenergic receptor antagonist (IC50 = 34.2 nM for α1; Kis = 0.06, 0.01, and 0.06 μM for α2A, α2B, and α2C, respectively) with antihypertensive activity. It forms a covalent bond with the adrenergic receptor, resulting in a slow onset and highly prolonged duration (2-8 days) of the blockade that subsides upon the synthesis of new adrenergic receptors. Due to its ability to selectively block longitudinal but not circular muscle contraction in human vas deferens, phenoxybenzamine has been explored as a form of male contraception to prevent sperm emission. The ability of phenoxybenzamine to block sympathetic signal transduction has also been explored in the context of complex regional pain syndrome.More related product prices
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