Phenoxybenzamine hydrochloride
- CAS No.
- 63-92-3
- Chemical Name:
- Phenoxybenzamine hydrochloride
- Synonyms
- PHENOXYBENZAMINE;dibenzyline;PHENOXYBENZAMINE HCL;688A;Bensylyt;benzylyt;SKF-688A;dibenylin;NSC 37448;dibenzyran
- CBNumber:
- CB8172020
- Molecular Formula:
- C18H22ClNO.ClH
- Molecular Weight:
- 340.29
- MOL File:
- 63-92-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/8/29 17:14:30
| Melting point | 137.5°C |
|---|---|
| storage temp. | 15-25°C |
| solubility | soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF). |
| form | powder |
| pka | pKa 4.4 (Uncertain) |
| color | white |
| Water Solubility | <0.01 g/100 mL at 18.5 ºC |
| Merck | 14,7256 |
| Stability | Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. |
| CAS DataBase Reference | 63-92-3(CAS DataBase Reference) |
| IARC | 2B (Vol. 24, Sup 7) 1987 |
| EPA Substance Registry System | N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine hydrochloride (63-92-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H351 | |||||||||
| Precautionary statements | P201-P301+P312+P330-P308+P313 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-40 | |||||||||
| Safety Statements | 22-36/37/39-45 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DP3750000 | |||||||||
| HS Code | 2922299000 | |||||||||
| NFPA 704 |
|
Phenoxybenzamine hydrochloride price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR1402 | Phenoxybenzamine Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material | 63-92-3 | 1G | ₹8270.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | B019 | Phenoxybenzamine hydrochloride ≥97%, powder | 63-92-3 | 250MG | ₹14094.15 | 2022-06-14 | Buy |
| TCI Chemicals (India) | D0158 | Phenoxybenzamine Hydrochloride | 63-92-3 | 1G | ₹4800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | D0158 | Phenoxybenzamine Hydrochloride | 63-92-3 | 25G | ₹14600 | 2022-05-26 | Buy |
Phenoxybenzamine hydrochloride Chemical Properties,Uses,Production
Description
Phenoxybenzamine hydrochloride (dibenzyline) is an orally effective, long-acting non-selective (alpha1 and alpha2) alpha-adrenoceptor blocking agent. It is used for the control of episodes of hypertension associated withpheochromocytoma. It literally produces a "chemical sympathectomy". It increases blood flow to the skin, mucosa and abdominal viscera, and lowers both supine and erect blood pressures. It has no effect on the parasympathetic system. The initialdose is 10 mg/day, increased by 10 mg every 4 days till the desired response is attained.The usual dosage range is 20-60mg/day.
Chemical Properties
white crystalline solid or powder. Odorless. soluble in ethanol, chloroform, propylene glycol, slightly soluble in benzene, slightly soluble in cold water. The melting point of its free base is 38-40 ° C, and it is soluble in benzene.
Uses
Phenoxybenzamine (5.0 to 60.0 mg/day) is used in order to control episodes of hypertension and sweating, it has a relatively slow onset and prolonged effect when compared to alternative α-blockers. If tachycardia is excessive, it may also be necessary to use a betablocker concomitantly. In addition, phenoxybenzamine has been tested for its efficacy in micturition disorders resulting from neurogenic bladder, functional outlet obstruction, and partial prostatic obstruction.
General Description
Phenoxybenzamine hydrochloride is a white crystalline powder. Melting point 137.5-140°C. Used as an antihypertensive drug.
Air & Water Reactions
Light sensitive and may be sensitive to exposure to air . Insoluble in water.
Mechanism of action
Phenoxybenzamine hydrochloride is a noncompetitive alpha-adrenergicreceptor blocker, and its action cannot be nullified by increasing the amount of agonist, or agonists. It causes epinephrine reversal in that the administration of epinephrine after pretreatment with phenoxybenzamine elicits vasodilation, and, conversely, phenoxybenzamine reverses epinephrine-mediated vasoconstriction to vasodilation. It may inhibit neuronal and extraneuronal uptake mechanisms of norepinephrine. At higher concentrations, it inhibits responses to 5-HT, histamine and acetylcholine.
Clinical Use
Oral phenoxybenzamine is used for the preoperativemanagement of patients with pheochromocytoma and in thechronic management of patients whose tumors are notamenable to surgery. Only about 20% to 30% of an oraldose is absorbed.
Side effects
The adverse effects of phenoxybenzamine include nasal congestion, miosis, postural hypotension, tachycardia, and inhibition of ejaculation.
Safety Profile
Confumed carcinogen with experimental carcinogenic and teratogenic data. Poison by intraperitoneal,intravenous, and subcutaneous routes. Human systemic effects by ingestion: changes in tubules, including acute renal failure, acute tubular necrosis. Moderately toxic by ingestion. Other experimental reproductive effects. Mutation data reported. A long-acting adrenergic blocker. When heated to decomposition it emits very toxic fumes of NOx and Cl-.
Carcinogenicity
Phenoxybenzamine hydrochloride is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
Dosage
Initially, 10 mg of Dibenzyline (phenoxybenzamine hydrochloride) twice a day. Dosage should be increased every other day, usually to 20 to 40 mg 2 or 3 times a day, until an optimal dosage is obtained, as judged by blood pressure control.
Phenoxybenzamine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Nuray Chemicals Pvt Ltd | +91-4066616700 +91-8220444745 | Tamil Nadu, India | 49 | 58 | Inquiry |
| Apothecon Pharmaceuticals Pvt Ltd | +91-2662244212 +91-9099007601 | Gujarat, India | 28 | 58 | Inquiry |
| Aruvi Labs | +91-8056181939 +91-8056181939 | Tamil Nadu, India | 149 | 58 | Inquiry |
| Laxai Life Sciences | +91-4023480125 +91-4023480125 | Hyderabad, India | 21 | 58 | Inquiry |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | +91-26463395 +91-7926462688 | Gujarat, India | 1615 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| MYLAN API US LLC | 080 6672 8000 | New Delhi, India | 44 | 58 | Inquiry |
| AUROBINDO PHARMA LTD | +91 (40) 6672 1200 | New Delhi, India | 209 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
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