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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Angiogenesis >HIF inhibitor >L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1:2)

L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1:2)

L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1:2) Structure
  • ₹0
  • Product name: L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1:2)
  • CAS: 685898-44-6
  • MF: C13H19Cl3N2O3
  • MW: 357.66
  • EINECS:
  • MDL Number:MFCD11840749
  • Synonyms:L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1:2);PX-478 dihydrochloride;PX478 2HCl;4-[bis(2-chloroethyl)oxidoamino]-L-phenylalanine,hydrochloride (1:2);PX-478 HCl;Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1:2);4-[Bis(2-chloroethyl)oxidoamino]-L-phenylalanine dihydrochloride;(S)-4-(2-Amino-2-carboxyethyl)-N,N-bis(2-chloroethyl)aniline oxide dihydrochloride
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :≥19.7 mg/mL in DMSO; ≥50 mg/mL in H2O; ≥8.42 mg/mL in EtOH
form :Powder
color :Off-white to yellow
CAS DataBase Reference :685898-44-6

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

PX 478 is a HIF-1α inhibitor that may be used in cancer therapy for treatment of solid tumors. PX478 has also been shown to suppress high-fat-diet (HFD)-induced HIFα activation in adipose tissue in mice and therefore may be used to ameliorate adipose tissue dysfunction.

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